Structural basis of an embryonically lethal single Ala → Thr mutation in the vnd/NK-2 homeodomain

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 13, 1998, Pages 7412-7416

  Xiang, Bosong ^a   Weiler, Solly ^a   Nirenberg, Marshall ^a   Ferretti, James A ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

DNA binding; Folding; Nuclear magnetic resonance; Structure

Indexed keywords

ALANINE; HOMEODOMAIN PROTEIN; THREONINE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; DNA BINDING; DNA DETERMINATION; HYDROGEN BOND; LETHAL MUTANT; NUCLEAR MAGNETIC RESONANCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; SPECTROMETRY; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CIRCULAR DICHROISM; DNA; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENES, LETHAL; HOMEODOMAIN PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; PROTEIN FOLDING; TEMPERATURE; TRANSCRIPTION FACTORS;

EID: 0032560466     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.13.7412     Document Type: Article

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