Site-directed mutations in the vnd/NK-2 homeodomain: Basis of variations in structure and sequence-specific DNA binding

Journal of Biological Chemistry

Volumn 273, Issue 18, 1998, Pages 10994-11000

  Weiler, Solly ^a   Gruschus, James M ^a   Tsao, Désirée H H ^a,c   Yu, Lei ^a   Wang, Lan Hsiang ^b   Nirenberg, Marshall ^b   Ferretti, James A ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NIH/NHLBI/LBG   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN;

ARTICLE; CIRCULAR DICHROISM; ELECTROPHORETIC MOBILITY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN DNA INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CIRCULAR DICHROISM; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HOMEODOMAIN PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; TRANSCRIPTION FACTORS;

DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0032079543     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.18.10994     Document Type: Article

References (52)

1. Gehring, W. J. (1987) Science 236, 1245-1252
2. Gehring, W. J., Affolter, M., and Burglin, T. (1994) Annu. Rev. Biochem. 63, 487-526
3. Skeath, J. B., Panganiban, G. F., and Carroll, S. B. (1994) Development 120, 1517-1524
4. Gehring, W. J., Qian, Y. Q., Billeter, M., Furukubo-Tokunaga, K., Schier, A. F., Resendez-Perez, D., Affolter, M., Otting, G., Wüthrich, K. (1994) Cell 78, 211-223
5. Scott, M. P., Tamkun, J. W., and Hartzell, G. W. (1989) Biochim. Biophys. Acta 989, 25-48
6. Schier, A. F., and Gehring, W. J. (1992) Nature 356, 804-807
7. Andrew, D. J., Horner, M. A., Petitt, M. G., Smolik, S, M., and Scott, M. P. (1994) EMBO J. 13, 1132-1144
8. Zeng, W., Andrew, D. J., Mathies, L. D., Horner, M. A., and Scott, M. P. (1993) Development 118, 339-352
9. Suzuki, M. (1994) Structure 2, 317-326
10. Suzuki, M., Brenner, S. E., Gerstein, M., and Yagi, N. (1995) Protein Eng. 8, 319-328
11. Lin, L., and McGinnis, W. (1992) Genes Dev. 6, 1071-1081
12. Heberlein, U., Penton, A., Falsafi, S., Hackett, D., and Rubin, G. M. (1994) Mech. Dev. 48, 35-49
13. Lyons, I., Parsons, L. M., Hartley, L., Li, R., Andrews, J. E., Robb, L., and Harvey, R. P. (1995) Genes Dev. 9, 1654-1666
14. Jiménez, F., Martin-Morris, L. E., Velasco, L., Chu, H., Sierra, J., Rosen, D. R., and White, K. (1995) EMBO J. 14, 3487-3495
15. Percival-Smith, A., Müller, M., Affolter, M., and Gehring W. J. (1990) EMBO J. 9, 3967-3974
16. Boncinelli, E. (1997) Curr. Opin. Genet. Dev. 7, 331-337
17. Frasch, M., Warrior, R., Tugwood, J., and Levine, M. (1988) Genes Dev. 2, 1824-1838
18. Ma, L., Golden, S., Wu, L., and Maxson, R. (1996) Hum. Mol. Genet. 5, 1915-1920
19. Wakimoto, B. T., Turner, F. R., and Kaufman, T. C. (1984) Dev. Biol. 102, 147-172
20. Hoey, T., and Levine, M. (1988) Nature 332, 858-861
21. Ekker, S. C., Jackson, D. G., von Kessler, D. P., Sun, B. I., Young, K. E., and Beachy, P. A. (1994) EMBO J. 13, 3551-3560
22. Chen, C. Y., and Schwartz, R. J. (1995) J. Biol. Chem. 270, 15628-15633
23. Chen, C. Y., Croissant, J., Majesky, M., Topouzis, S., McQuinn, T., Frankovsky, M. J., and Schwartz, R. J. (1996) Dev. Genet. 19, 119-130
24. Laughon, A. (1991) Biochemistry 30, 11357-11367
25. Qian, Y.-Q., Billeter, M., Otting, G., Müller, M., Gehring, W. J., and Wüthrich, K. (1988) Cell 59, 573-580
26. Billeter, M., Qian, Y.-Q., Otting, G., Müller, M., Gehring, W. J., and Wüthrich, K. (1993) J. Mol. Biol. 234, 1084-1097
27. Kissinger, C. R., Liu, B. S., Martin-Blanco, E., Kornberg, T. B., and Pabo, C. O. (1990) Cell 63, 579-590
28. Wolberger, C., Vershon, A. K., Liu, B., Johnson, A. D., and Pabo, C. O. (1991) Cell 67, 517-528
29. Li, T., Stark, M. R., Johnson, A. D., and Wolberger, C. (1995) Science 270, 262-269
30. Klemm, J. D., Rould, M. A., Aurora, R., Herr, W., and Pabo, C. O. (1994) Cell 77, 21-32
31. Hirsch, J. A., and Aggarwal, A. K. (1995) EMBO J. 14, 6280-6291
32. Wilson, D. S., Guenther, B., Desplan, C., and Kuriyan, J. (1995) Cell 82, 709-719
33. Gruschus, J. M., Tsao, D. H. H., Wang, L.-H., Nirenberg, M., and Ferretti, J. A., (1997) Biochemistry 36, 5372-5380
34. Draganescu, A., Levin, J. R., and Tullius, T. D. (1995) J. Mol. Biol. 250, 595-608
35. Damante, G., Fabbro, D., Pellizzari, L., Civitareale, D., Guazzi, S., Polycarpou-Schwartz, M., Cauci, S., Quadrifoglio, F., Formisano, S., and DiLauro, R. (1994) Nucleic Acids Res. 22, 3075-3083
36. Damante, G., Pellizzari, L., Esposito, G., Fogolari, F., Viglino, P., Fabbro, D., Tell, G., Formisano, S., and DiLauro, R. (1996) EMBO J. 15, 4992-5000
37. White, K. (1980) Dev. Biol. 80, 332-344
38. Kim., Y., and Nirenberg, M. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 7716-7720
39. Harvey, R. P. (1996) Dev. Biol. 178, 203-216
40. Mellerick, D., and Nirenberg, M. (1995) Dev. Biol. 171, 306-316
41. Nirenberg, M., Nakayama, K., Nakayama, N., Kim, Y., Mellerick, D., Wang, L.-H., Webber, K., and Lad, R. (1995) Ann. N. Y. Acad. Sci. 758, 224-242
42. Tsao, D. H. H., Gruschus, J. M., Wang, L.-H., Nirenberg, M., and Ferretti, J. A. (1994) Biochemistry 33, 15053-15060
43. Tsao, D. H. H., Gruschus, J. M., Wang, L.-H., Nirenberg, M., and Ferretti, J. A. (1995) J. Mol. Biol. 251, 297-307
44. Billeter, M., Qian, Y.-Q., Otting, G., Müller, M., Gehring, W. J., and Wüthrich, K. (1990) J. Mol. Biol. 214, 183-197
45. Qian, Y.-Q., Furukubo-Tokunaga, K., Resendez-Perez, D., Müller, M., Gehring, W. J., and Wüthrich, K. (1994) J. Mol. Biol. 238, 333-345
46. Weiler, S., Tsao, D. H. H., Gruschus, J. M., Yu, L., Wang, L.-H., Nirenberg, M., and Ferretti, J. A. (1996) Biophys. J. 70, A342
47. Higuchi, R., Krummel, B., and Saiki, R. K. (1988) Nucleic Acids Res. 15, 7351-7367
48. Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, John Wiley & Sons, Inc., New York
49. Damante, G., Tell, G., Leonardi, A., Fogolari, F., Bortolotti, N., Di Lauro, R., and Formisano, S. (1994) FEBS Lett. 354, 293-296
50. Reecy, J. M., Yamada, M., Cummings, K., Sosic, D., Chen, C.-Y., Eichele, G., Olson, E. N., and Schwartz, R. J. (1997) Dev. Biol. 188, 295-311
51. Okkema, P. G., and Fire, A. (1994) Development 120, 2175-2186
52. Affolter, M., Percival-Smith, A., Müller, M., Leupin, W., and Gehring, W. J. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 4093-4097