Synthesis and binding of stable bisubstrate ligands for phosphoglycerate kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 18, 1998, Pages 2603-2608

  Williams, David M ^a   Jakeman, David L ^a   Vyle, Joseph S ^a   Williamson, Michael P ^a   Blackburn, G Michael ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; GLYCERIC ACID; LIGAND; PHOSPHOGLYCERATE DERIVATIVE; PHOSPHOGLYCERATE KINASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIPHOSPHOGLYCERIC ACIDS; DRUG DESIGN; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; PHOSPHOGLYCERATE KINASE;

EID: 0032558478     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00466-1     Document Type: Article

References (25)

1. 1. Scopes, R. K. In The Enzymes, 3rd ed., Boyer, P. D. Ed.; Academic Press: New York, 1973; Vol VIII, Ch. 10.
2. 2. Bryant, T. N.; Watson, H. C.; Wendel, P. L. Nature (London) 1974, 247, 14.
3. 3. Watson, H. C.; Walker, N. P. C.; Shaw, P. J.; Bryant, T. N.; Wendell, P. L.; Fothergill, L. A.; Perkins, R. E.; Conroy, S. C.; Dobson, C. J.; Tuite, M. F.; Kingsman, A. J.; Kingsman, S. M. EMBO J., 1982, 1, 1635.
4. 4. Banks, R. D.; Blake, C. C. F.; Evans, P. R.; Haser, R.; Rice, D. W.; Hardy, G. W.; Merrett, M.; Phillips, A. W. Nature (London) 1979, 279, 773
5. 5. Harlos, K.; Vas, M.; Blake, C. C. F. Proteins Struct. Funct. Genet. 1992, 12, 133.
6. 6. Davies, G. J.; Gamblin, S. J.; Littlechild, J. A.; Dauter, Z.; Wilson, K. S.; Watson, H. C. Acta Cryst.,D 1994, 50, 202.
7. 7. Blake, C. C. F.; Rice, D. Phil. Trans. Roy. Soc. Lond. A. 1981, 293, 93. Rice, D.; Blake, C. C. F. J. Mol. Biol 1984, 175, 219.
8. 7. Blake, C. C. F.; Rice, D. Phil. Trans. Roy. Soc. Lond. A. 1981, 293, 93. Rice, D.; Blake, C. C. F. J. Mol. Biol 1984, 175, 219.
9. 8. Muller, C. W.; Schulz G. E. J. Mol. Biol. 1992, 224, 159.
10. 9. Lavie, A.; Konrad, M.; Brundiers, R.; Goody, R. S.; Schlichting, I.; Reinstein, J. Biochemistry 1998, 37, 3677.
11. 10. Schlichting, I.; Reinstein, J. Protein Eng. 1997, 10, 58.
12. 11. Webb, M. R.; Trentham, D. R. J. Biol. Chem. 1980, 255, 1775.
13. 12. Bernstein, B. E.; Hol, W. G. J. Biochemistry 1998, 37, 4429. See also Auerbach, G.; Huber, R.; Grättinger, M.; Zaiss, K.; Schurig, H.; Jaenicke, R.; Jacob, U. Structure 1997, 5, 1475 for similar data derived from T. maritima PGK.
14. 12. Bernstein, B. E.; Hol, W. G. J. Biochemistry 1998, 37, 4429. See also Auerbach, G.; Huber, R.; Grättinger, M.; Zaiss, K.; Schurig, H.; Jaenicke, R.; Jacob, U. Structure 1997, 5, 1475 for similar data derived from T. maritima PGK.
15. 13. Blackburn, G. M.; Jakeman, D. L.; Ivory, A. J; Williamson, M. P. Bioorg. Med Chem. Lett. 1994, 4, 2573; Jakeman, D. L.; Ivory, A. J.; Williamson M. P.; Blackburn G. M. J. Med. Chem. 1998, in press.
16. 13. Blackburn, G. M.; Jakeman, D. L.; Ivory, A. J; Williamson, M. P. Bioorg. Med Chem. Lett. 1994, 4, 2573; Jakeman, D. L.; Ivory, A. J.; Williamson M. P.; Blackburn G. M. J. Med. Chem. 1998, in press.
17. 13
18. 15. Moffatt J. G.; Khorana H.G. J. Am. Chem. Soc. 1961, 83, 649.
19. 16. Verheyden J. L. M.; Wehrli W. E.; Moffatt J. G. J. Am. Chem. Soc. 1965, 87, 1965.
20. 17. Wehrli, W. E.; Verheyden, J. L. M.; Moffatt, J. G. J. Am. Chem. Soc. 1965, 87, 2265.
21. 18. Bernstein, B. E.; Williams, D. M.; Bressi, J. C.; Kuhn, P.; Gelb, M. H.; Blackburn, G. M.; Hol, W. G. J. J. Mol Biol. 1998, 279, 1137.
22. 19. Wiesmuller, L.; Scheffzek, K.; Kliche, W.; Goody, R. S.; Wittinghofer, A.; Reinstein, J. FEBS Lett. 1995, 363, 22.
23. 20. Lienhard, G. E.; Secemski, I. L. J. Biol. Chem. 1973, 248, 1121.
24. 21. Liu, X.; Zhang, X-R.; Blackburn, G. M. J. Chem. Soc., Chem. Commun. 1997, 87.
25. 22. Boyle, H. A.; Fairbrother, W. J.; Williams, R. J. P. Eur. J. Biochem. 1989, 184, 535.