Absence of a differential induction of cytochrome P450 2E1 by different alcoholic beverages in rats: Implications for the aetiology of human oesophageal cancer

Archives of Toxicology

Volumn 71, Issue 11, 1997, Pages 690-695

  Lechevrel, Mathilde ^a   Wild, Christopher P ^a,b  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Alcohol; Cytochrome P450 2E1; N nitrosamines; Oesophageal cancer

Indexed keywords

ALCOHOL; CYTOCHROME P450 ISOENZYME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENZYME INDUCTION; ESOPHAGUS CANCER; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ALCOHOLIC BEVERAGES; ANIMALS; BLOTTING, WESTERN; CYTOCHROME P-450 CYP2E1; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INDUCTION; ESOPHAGEAL NEOPLASMS; HUMANS; INDICATORS AND REAGENTS; MALE; MIXED FUNCTION OXYGENASES; RATS; RATS, INBRED STRAINS;

ANIMALIA; MALUS X DOMESTICA;

EID: 0030772530     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050446     Document Type: Article

References (34)

1. Burke MD, Thompson S, Elcombe CR, Halpert J, Haaparanta T, Mayer RT (1985) Ethoxy-, penthoxy- and benzyloxyphtnoxazones and homologues: a series of the substrates to distinguish between different induced cytochromes P450. Biochem Pharmacol 34: 3337-3345
2. Camus AM, Geneste O, Honkakoski P, Bereziat JC, Henderson CJ, Wolf CR, Bartsch H, Lang MA (1993) High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of n-nitrosodimethylamine and n-nitrosodiethylamine in mice and humans. Mol Carcinogenesis 7: 268-275
3. Castonguay A, Pepin P, Briere N (1991) Modulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1 butanone demethylation and denitrosation by rat liver microsomes. Cancer Lett 59: 67-74
4. Craddock VM (1993) Alcoholic beverages and tobacco. In: Craddock VM (ed) Cancer of the esophagus. Approaches to the etiology. Cambridge Monographs on Cancer Research. Cambridge University Press, pp 117-169
5. Craddock VM, Henderson AR (1991) Potent inhibition of oesophageal metabolism of N-nitrosomethylbenzylamine, an oesophageal carcinogen, by higher alcohols present in alcoholic beverages. In: O'Neill IK, Chen J, Bartsch H (eds) Relevance to human cancer of N-nitroso compounds, tobacco smoke and mycotoxins. International Agency for Research on Cancer, Lyon, France, pp 564-567
6. Crespi CL, Penman BW, Gelboin HV, Gonzalez FJ (1991) A tobacco smoke derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6. Carcinogenesis 12: 1197-1201
7. Forrester LM, Henderson CJ, Glancey MJ, Back DJ, Park BK, Ball SE, Kitteringham NR, McLaren AW, Miles JS, Skett P (1992) Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics. Biochem J 281: 359-368
8. International Agency for Research on Cancer (1988) Monographs on the evaluation carcinogenic risks to humans: alcohol drinking, volume 44. IARC, Lyon, France
9. Lieber CS (1990) Mechanism of ethanol induced hepatic injury. Pharmacol Ther 46: 1-41
10. Lowry OH, Rosebrough NJ, Farr AL, Randall FJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275
11. Mirvish SS (1995) Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC. Cancer Lett 93: 17-48
12. Nakajima T, Wang RS, Nimura Y, Pin YM, He M, Vainio H, Murayama N, Aoyama T, Iida F (1996) Expression of cytochrome P450s and glutathione S-transferases in human esophagus with squamous-cell carcinomas. Carcinogenesis 17: 1477-1481
13. Nash T (1953) The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochem J 55: 416-421
14. Omura T, Sato R (1964) The carbon monoxide binding pigment of liver microsomes: solubilization purification and properties. J Biol Chem 239: 2379-2385
15. Park SS, Ko Y, Patten C, Yang CS, Gelboin HV (1986) Monoclonal antibodies to ethanol induced cytochrome P450 that inhibit aniline and nitrosamine metabolism. Biochem Pharmacol 35: 2855-2858
16. Parkin DM, Muir CS, Whelan SL, Gao Y-T, Ferlay J, Powell J (1992) Cancer incidence in five continents, volume VI. IARC Scientific Publication 120. IARC, Lyon, France
17. Perrot N, Nalpas B, Yang CS, Beaune PH (1989) Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake. Eur J Clin Invest 19: 549-555
18. Reinke LA, Moyer J (1985) p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol. Drug Metab Dispos 13: 548-552
19. Roberts BJ, Shoaf SE, Jeong KS, Song BJ (1994) Induction of CYP2E1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less. Biochem Biophys Res Commun 205: 1064-1071
20. Rogers MA, Vaughan TL, Davis S, Thomas DB (1995) Consumption of nitrate, nitrite, and nitrosodimethylamine and the risk of upper aerodigestive tract cancer. Cancer Epidemiol Biomarkers Prev 4: 29-36
21. Shimizu MO, Lasker JM, Tsutsumi M, Lieber CS (1990) Immunohistochemical localization of ethanol-inducible P450 IIE1 in the rat alimentary tract. Gastroenterology 99: 1044-1053
22. Song BJ, Gelboin HV, Park SS, Yang CS, Gonzalez FJ (1986) Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P450s. J Biol Chem 261: 16689-16697
23. Song BJ, Veech RL, Park SS, Gelboin HV, Gonzalez FJ (1989) Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization. J Biol Chem 264: 3568-3572
24. Swann PF, Graves RJ, Mace R (1987) Effect of ethanol on nitrosamine metabolism and distribution - implication for the role of nitrosamines in human cancer and for the influence of alcohol consumption on cancer incidence. Mutat Res 186: 261-267
25. Takahashi T, Lasker JM, Rosman AS, Lieber CS (1993) Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology 17: 236-245
26. Tuyns AJ, Pequignot G, Jensen OM (1977) Le cancer de l'esophage en Ille-et-Vilaine en fonction des niveaux de consommation d'alcool et de tabac. Des risques qui se multiplient. Bull Cancer 64: 45-60
27. Tuyns AJ, Pequignot G, Abbatucci JS (1979) Oesophageal cancer and alcohol consumption: importance of type of beverage. Int J Cancer 23: 443-447
28. Tuyns AJ, Castegnaro M, Toussaint G, Walker EA, Griciute LL, Le Talaer JY, Loquet C, Guerain J, Drilleau JF (1980) Recherches concernant les facteurs etiologiques du cancer de l'oesophage dans l'ouest de la France. Bull Cancer 67: 2-28
29. 6-Methyldeoxyguanosine in oesophageal DNA among individuals at high risk of oesophageal cancer. Int J Cancer 36: 661-665
30. Wilson JS, Korsten MA, Lieber CS (1986) The combined effects of protein deficiency and chronic ethanol administration on rat ethanol metabolism. Hepatology 6: 823-829
31. Wrighton SA, Thomas PE, Ryan DE, Levin W (1987) Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj. Arch Biochem Biophys 258: 292-297
32. Yamada Y, Weller RO, Kleihues P, Ludeke BI (1992) Effects of ethanol and various alcoholic beverages on the formation of O6-methyldeoxyguanosine from concurrently administered N-nitrosomethylbenzylamine in rats: a dose-response study. Carcinogenesis 13: 1171-1175
33. Yang CS, Yoo JS, Ishizaki H, Hong JY (1990) Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation. Drug Metab Rev 22: 147-159
34. Yu MC, Garabrant DH, Peters JM, Mack TM (1988) Tobacco, alcohol, diet, occupation, and carcinoma of the oesophaeus. Cancer Res 48: 3843-3848