The mutagenic activity of ethylnitrosourea at low doses in spermatogonia of the mouse as assessed by the specific-locus test

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 405, Issue 2, 1998, Pages 221-226

  Favor, Jack ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Ethylnitrosourea; Mouse; Spermatogonia

Indexed keywords

ETHYLNITROSOUREA;

CONFERENCE PAPER; DNA ADDUCT; DOSE RESPONSE; GENE LOCUS; GENE MUTATION; MUTAGENIC ACTIVITY; MUTATION RATE; PRIORITY JOURNAL; SPERMATOGONIUM;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLNITROSOUREA; MALE; MICE; MICE, INBRED C3H; MUTAGENICITY TESTS; MUTAGENS; PHENOTYPE; SPERMATOGONIA;

EID: 0032552633     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(98)00139-0     Document Type: Conference Paper

References (34)

1. [1] W.L. Russell, X-ray-induced mutations in mice, Cold Spring Harbor Symp. Quant. Biol. 16 (1951) 327-336.
2. [2] U.H. Ehling, A. Neuhäuser-Klaus, Dose-effect relationships of germ-cell mutations in mice, in: Y. Tazima, S. Kondo, Y. Kuroda (Eds.), Problems of Threshold in Chemical Mutagenesis, Kokusai-bunken, Tokyo, 1984, pp. 12-25.
3. [3] J. Favor, M. Sund, A. Neuhäuser-Klaus, U.H. Ehling, A dose response analysis of ethylnitrosourea-induced recessive specific-locus mutations in treated spermatogonia of the mouse, Mutat. Res. 231 (1990) 47-54.
4. [4] W.L. Russell, P.R. Hunsicker, G.D. Raymer, M.H. Steele, K.F. Stelzner, H.M. Thompson, Dose response curve for ethylnitrosourea-induced specific-locus mutations in mouse spermatogonia, Proc. Natl. Acad. Sci. USA 79 (1982) 3589-3591.
5. [5] J. Favor, A. Neuhäuser-Klaus, U.H. Ehling, The effect of dose fractionation on the frequency of ethylnitrosourea-induced dominant cataract and recessive specific locus mutations in germ cells of the mouse, Mutat. Res. 198 (1988) 269-275.
6. [6] S. Hitotsumachi, D.A. Carpenter, W.L. Russell, Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia, Proc. Natl. Acad. Sci. USA 82 (1985) 6619-6621.
7. [7] W.L. Russell, P.R. Hunsicker, D.A. Carpenter, C.V. Cornett, G.M. Guinn, Effect of dose fractionation on the ethylnitrosourea induction of specific-locus mutations in mouse spermatogonia, Proc. Natl. Acad. Sci. USA 79 (1982) 3592-3593.
8. [8] J. Favor, A. Neuhäuser-Klaus, U.H. Ehling, A. Wulff, A.A. van Zeeland, The effect of the interval between dose applications on the observed specific-locus mutation rate in the mouse following fractionated treatments of spermatogonia with ethylnitrosourea, Mutat. Res. 374 (1997) 193-199.
9. [9] U.H. Ehling, A. Neuhäuser-Klaus, Induction of specific-locus mutations in female mice by 1-ethyl-1-nitrosourea and procarbazine, Mutat. Res. 202 (1988) 139-146.
10. 1 mice derived from post-spermatogonial treatment with ethylnitrosourea, Mutat. Res. 229 (1990) 105-114.
11. [11] L.B. Russell, J.W. Bangham, K.F. Stelzner, P.R. Hunsicker, High frequency of mosaic mutations produced by N-ethyl-N-nitrosourea exposure of mouse zygotes, Proc. Natl. Acad. Sci. USA 85 (1988) 9167-9170.
12. [12] J. Favor, A. Neuhäuser-Klaus, U.H. Ehling, The induction of forward and reverse specific-locus mutations and dominant cataract mutations in spermatogonia of treated strain DBA/2 mice by ethylnitrosourea, Mutat. Res. 249 (1991) 293-300.
13. [13] U.H. Ehling, J. Favor, Recessive and dominant mutations in mice, in: E.H.Y. Chu, W.M Generoso (Eds.), Mutation, Cancer and Malformation, Plenum, New York, 1984, pp. 389-428.
14. [14] A.G. Searle Mutation induction in mice, in: J.T. Lett, H. Adler, M. Zeile (Eds.), Advances in Radiation Biology, Vol. 4, Academic Press, New York, 1974, pp. 131-209.
15. [15] P. Armitage, The assessment of low-dose carcinogenicity, Biometrics, Supplement: Current topics in biostatistics and epidemiology, 1982, pp. 119-129.
16. [16] J. Van Ryzin, Discussion of the paper by Armitage, The assessment of low-dose carcinogenicity, Biometrics, Supplement: Current topics in biostatistics and epidemiology, 1982, pp. 130-139.
17. [17] W.J. Dixon, BMDP Statistical Software, University of California Press, Berkeley, CA, 1983.
18. [18] P. McCullagh, J.A. Nelder, Generalized Linear Models, Chapman & Hall, London, 1983.
19. [19] J. Favor, Toward an understanding of the mechanisms of mutation induction by ethylnitrosourea in germ cells of the mouse, in: J.W. Allen, B.A. Bridges, M.F. Lyon, M.J. Moses, L.B. Russell (Eds.), Banbury Report 34: Biology of Mammalian Germ Cell Mutagenesis, Cold Spring Harbor Press, Cold Spring Harbor, NY, 1990, pp. 221-235.
20. [20] P. Oftedal, A theoretical study of mutant yield and cell killing after treatment of heterogeneous cell populations, Hereditas 60 (1968) 177-210.
21. [21] G.A. Sega, C.R. Rohrer, H.R. Harvey, A.E. Jetton, Chemical dosimetry of ethyl nitrosourea in the mouse testis, Mutat. Res. 159 (1986) 65-74.
22. [22] E.F. Oakberg, Spermatogonial stem cell renewal in the mouse, Anat. Rec. 169 (1971) 119-127.
23. [23] D.G. De Rooij, Y. van der Meer, A.M.M. van Pelt, P.P.W. van Buul, Correlation between proliferative activity of mouse spermatogonial stem cells and their sensitivity for cell killing and induction of reciprocal translocations by irradiation, in: J.W. Allen, B.A. Bridges, M.F. Lyon, M.J. Moses, L.B. Russell (Eds.), Banbury Report 34: Biology of Mammalian Germ Cell Mutagenesis, Cold Spring Harbor Press, Cold Spring Harbor, NY, 1990, pp. 35-49.
24. [24] J. Jones, J. Peters, The molecular characterization of an A:T to G:C transition in the Hbb-b1 gene of the murine homologue of hemoglobin Rainier, Biochem. Genet. 29 (1991) 617-626.
25. [25] R. Sandulache, W. Pretsch, B. Chatterjee, W. Gimbel, J. Graw, J. Favor, Molecular analysis of four lactate dehydrogenase-A mutants in the mouse, Mammalian Genome 5 (1994) 777-780.
26. [26] W. Pretsch, B. Chatterjee, J. Favor, S. Merkle, R. Sandulache, Molecular, genetic and biochemical characterization of lactate dehydrogenase-A enzyme-activity mutants in Mus musculus, Mammalian Genome 9 (1998) 144-149.
27. [27] S.P. Cordes, O.S. Barsh, The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor, Cell 79 (1994) 1025-1034.
28. [28] F. Gibson, J. Walsh, P. Mbura, A. Varela, K.A. Brown, M. Antonio, K.W. Beisel, K.P. Steel, S.D.M. Brown, A type VII myosin encoded by the mouse deafness gene shaker-1, Nature 374 (1995) 622-664.
29. [29] E. Zdarsky, J. Favor, I.J. Jackson, The molecular basis of brown, an old mouse mutation, and of an induced revenant to wild type, Genetics 126 (1990) 443-449.
30. [30] S.R. Pearce, J. Peters, S. Ball, M.J. Morgan, J.I.H. Walker, P. Faik, Sequence characterization of ENU-induced mutants of glucose phosphate isomerase in mouse, Mammalian Genome 6 (1995) 858-861.
31. [31] R.F. Hill, J. Favor, B.L.M. Hogan, C.C.T. Ton, G.F. Saunders, I.M. Hanson, J. Presser, T. Jordan, N.D. Hastie, V. van Heyningen, Mouse small-eye results from mutations in a paired-like homeobox-containing gene, Nature 354 (1991) 5222-5525.
32. [32] L.-K. Su, K.W. Kinzler, B. Vogelstein, A.C. Preisinger, A.R. Moser, C. Luongo, K.A. Gould, W.F. Dove, Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene, Science 256 (1992) 668-670.
33. [33] B.C. Zingg, W. Pretsch, H.W. Mohrenweiser, Molecular analysis of four ENU induced triosephosphate isomerase null mutants in Mus musculus, Mutat. Res. 328 (1995) 163-173.
34. [34] P.C. Marker, K. Seung, A.E. Bland, L.B. Russell, D.M. Kingsley, Spectrum of Bmp5 mutations from germline mutagenesis experiments in mice, Genetics 145 (1997) 435-443.