Substrate specificity of human prolyl-4-hydroxylase

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 10, 1998, Pages 1139-1144

  Tandon, Manish ^a   Wu, Min ^a   Begley, Tadhg P ^a   Myllyharju, Johanna ^b   Pirskanen, Asta ^b   Kivirikko, Kari ^b  

^a Department of Molecular Biology and Genetics   (United States)

^b UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE DERIVATIVE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE DERIVATIVE;

ARTICLE; CATALYSIS; ENZYME MECHANISM; ENZYME SPECIFICITY; HUMAN; HYDROXYLATION;

HUMANS; HYDROXYLATION; INDICATORS AND REAGENTS; MOLECULAR STRUCTURE; PROCOLLAGEN-PROLINE DIOXYGENASE; PROLINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0032546523     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00183-8     Document Type: Article

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33. 1H NMR and FAB-HRMS. Peptides 16 and 19 were purified as a single compound, peptides 20, 22, 28, 29 and 31 were purified as a mixture of the two indicated isomers.
34. 4 (0.0025 mM), ascorbic acid (0.1 mM), BSA (0.1 mg), catalase (0.0005 mg), DTT (0.005 mM), α-ketoglutarate (0.025 mM) tris.HCl (50 mM, pH 7.8) prolyl-4-hydroxylase (0.15 mg) in 500 μL volume.
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