Towards the semi-synthesis of didemnin M. solution and solid phase synthesis of the pseudotetrapeptide: pGlu-Glnψ[COO]Ala-Pro-OH

Tetrahedron Letters

Volumn 39, Issue 8, 1998, Pages 779-782

  Wen, James J ^a   Crews, Craig M ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIDEMNIN B; DIDEMNIN M; PSEUDOPEPTIDE; PSEUDOTETRAPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ESTERIFICATION; MOLECULAR PROBE; NONHUMAN;

EID: 0032546140     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10609-8     Document Type: Article

References (10)

1. 1. Rinehart, K.L.; Gloer, J. B.; Hughes, R. G.; Renis, H. E.; McGovren, J. P.; Swynenberg, E.B.; Stringfellow, D.A.; Kuentzel, S. L.; Li, L.H. Science 1981, 212, 933-935.
2. 2. Sakai, R.; Stroh, J.G.; Sullins, D.W.; Rinehart, K.L. J. Am. Chem. Soc. 1995, 117, 3734-3748.
3. 3. Sakai, R.; Rinehart, K. L.; Kishore, V.; Kundu, B.; Faircloth, G.; Gloer, J. B.; Carney, J. R.; Namikoshi, M.; Sun, F.; Hughes, R. G.; Gravalos, D. G.; Dequesada, T. G.; Wilson, G. R.; Heid, R. M. J. Med. Chem. 1996, 39, 2819-2834.
4. 4. Crews, C.M.; Collins, J.L.; Lane, W.S.; Snapper, M.L.; Schreiber, S.L. J. Biol. Chem. 1994, 269, 15411-15414.
5. 5. Crews, C.M. Lane, W.S.; Schreiber, S.L. Proc. Natl. Acad. Sci. USA 1996, 4316-4319.
6. +] 170.2, found 170.1.
7. +] 427.4, found 427.2.
8. 8. Campbell, D.A.; Bermak, J. C. J. Am. Chem. Soc. 1994, 116, 6039-6040.
9. 9. Krchnak, V.; Cabel, D.; Weichsel, A.; Flegelova, Z.; Letters in Peptide Science 1994, 1, 277-282.
10. D = -0.236 (c= 0.5, MeOH).