Binding capacity of FK506 binding protein after 2-hour hemispheric ischemia in gerbil brain

Brain Research

Volumn 781, Issue 1-2, 1998, Pages 1-7

  Nozaki, Hiroyuki ^a   Tanaka, Kortaro ^a   Shirai, Toshitaka ^a   Nagata, Eiichiro ^a   Kondo, Taro ^a   Koyama, Satoshi ^a   Dembo, Tomohisa ^a   Fukuuchi, Yasuo ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Calcineurin; Cerebral blood flow; Cerebral ischemia; FK506; FK506 binding protein; Gerbil

Indexed keywords

FK 506 BINDING PROTEIN; IODOPHENAZONE C 14; LIGAND; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN PROTECTION; BRAIN REGION; COMMON CAROTID ARTERY; CONTROLLED STUDY; GERBIL; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SCATCHARD PLOT; THALAMUS;

ANIMALS; BINDING SITES; CARRIER PROTEINS; CEREBROVASCULAR CIRCULATION; DNA-BINDING PROTEINS; GERBILLINAE; HEAT-SHOCK PROTEINS; ISCHEMIC ATTACK, TRANSIENT; MALE; PROTEIN BINDING; TACROLIMUS BINDING PROTEINS;

EID: 0032545735     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01130-X     Document Type: Article

References (23)

1. Bierer B.E., Mattila P.S., Standaert R.F., Herzenberg L.A., Burakoff S.J., Crabtree G., Schreiber S.L. Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc. Natl. Acad. Sci. USA. 87:1990;9231-9235.
2. Dawson T.M., Steiner J.P., Dawson V.L., Dinerman J.L., Uhl G.R., Snyder S.H. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc. Natl. Acad. Sci. USA. 90:1993;9808-9812.
3. Dawson T.M., Steiner J.P., Lyons W.E., Fotuhi M., Blue M., Snyder S.H. The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin. Neuroscience. 62:1994;569-580.
4. Dawson T.M. Immunosuppressants, immunophilins, and the nervous system. Ann. Neurol. 40:1996;559-560.
5. Drake M., Friberg H., Boris-Möller F., Sakata K., Wieloch T. The immunosuppressant FK506 ameliorates ischemic damage in the rat brain. Acta Physiol. Scand. 158:1996;155-159.
6. Ide T., Morikawa E., Kirino T. An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the Mongolian gerbil. Neurosci. Lett. 204:1996;157-160.
7. Ito U., Spatz M., Walker J.T. Jr., Klatzo I. Experimental cerebral ischemia in Mongolian gerbils. I. Light microscopic observations. Acta Neuropathol. (Berl.). 32:1975;209-223.
8. 14C]iodoantipyrine in the mouse. J. Cereb. Blood Flow Metab. 8:1988;121-129.
9. Lyons W.E., George E.B., Dawson T.M., Steiner J.P., Snyder S.H. Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. Proc. Natl. Acad. Sci. USA. 91:1994;3191-3195.
10. Lyons W.E., Steiner J.P., Snyder S.H., Dawson T.M. Neuronal regeneration enhances the expression of the immunophilin FKBP-12. J. Neurosci. 15:1995;2985-2994.
11. Nozaki H., Tanaka K., Gomi S., Mihara B., Nagata E., Kondo T., Fukuuchi Y. Relationship between stroke index (McGraw) and local cerebral blood flow in the gerbil ischemia model with unilateral occlusion of the common carotid artery. J. Jpn. Coll. Angiol. 36:1996;243-250.
12. 14C]antipyrine. Am. J. Physiol. 234:1978;H59-H66.
13. Schreiber S.L. Chemistry and biology of immunophilins and their immunosuppressive ligands. Science. 251:1991;283-287.
14. Sharkey J., Butcher S.P. Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischemia. Nature. 371:1994;336-339.
15. Snyder S.H., Sabatini M. Immunophilins and the nervous system. Nature Med. 1:1995;32-37.
16. Steiner J.P., Dawson T.M., Fotuhi M., Glatt C.E., Snowman A.M., Cohen N., Snyder S.H. High brain densities of the immunophilin FKBP colocalized with calcineurin. Nature. 358:1992;584-587.
17. Steiner J.P., Connolly M.A., Valentine H.L., Hamilton G.S., Dawson T.M., Hester L., Snyder S.H. Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Nature Med. 3:1997;421-428.
18. Takashima S., Gotoh F., Ishihara N., Tanaka K., Gomi S., Mihara B. Quantitative autoradiographic analysis of second-messenger systems and regional blood flow in the same gerbil brain. Auton. Nerv. Syst. 27:1990;35-42.
19. Tanaka K., Gotoh F., Ishihara N., Gomi S., Takashima S., Mihara B. Autoradiographic analysis of second-messenger systems in the gerbil brain. Brain Res. Bull. 21:1988;693-700.
20. Tanaka K., Gotoh F., Gomi S., Takashima S., Mihara B. Autoradiographic analysis on second-messenger systems and local cerebral blood flow in ischemic gerbil brain. J. Cereb. Blood Flow Metab. 11:1991;283-291.
21. Tanaka K., Fukuuchi Y., Gomi S., Takashima S., Mihara B., Shirai T., Nogawa S., Nozaki H., Nagata E. Alteration of second-messenger ligand binding following 2-h hemispheric ischemia in the gerbil brain. Exp. Neurol. 117:1992;254-259.
22. Tanaka K., Fukuuchi Y., Nozaki H., Nagata E., Kondo T., Koyama S., Dembo T. Calcineurin inhibitor, FK506, prevents reduction in the binding capacity of cyclic AMP-dependent protein kinase in ischemic gerbil brain. J. Cereb. Blood Flow Metab. 17:1997;412-420.
23. Tokime T., Nozaki K., Kikuchi H. Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil. Neurosci. Lett. 206:1996;81-84.