Induction of immunologic memory by conjugated vs plain meningococcal C polysaccharide vaccine in toddlers: A randomized controlled trial

JAMA

Volumn 280, Issue 19, 1998, Pages 1685-1689

  MacDonald, Noni E ^a,f   Halperin, Scott A ^b   Law, Barbara J ^c   Forrest, Bruce ^d   Danzig, Lisa E ^d   Granoff, Dan M ^d,e  

^a UNIVERSITY OF OTTAWA   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

^c UNIVERSITY OF MANITOBA   (Canada)

^d NOVARTIS PHARMA AG   (Switzerland)

^e CHILDREN S HOSPITAL OAKLAND   (United States)

^f CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM ANTIBODY; CRM 197; HEPATITIS B VACCINE; IMMUNOGLOBULIN G; MENINGOCOCCUS VACCINE; POLYSACCHARIDE VACCINE; UNCLASSIFIED DRUG;

ANTIBODY RESPONSE; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG CONJUGATION; DRUG FORMULATION; FEMALE; HUMAN; HUMAN EXPERIMENT; IMMUNIZATION; IMMUNOGENICITY; IMMUNOLOGICAL MEMORY; MALE; MULTICENTER STUDY; NEISSERIA MENINGITIDIS; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

EID: 0032544968     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.280.19.1685     Document Type: Article

References (23)

1. Jafari HS, Perkins BA, Wenger JD. Control and prevention of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep. 1997;46:1-10.
2. Ramsay M, Kaezmarski E, Rush M, Mallard R, Farrington P, White J. Changing patterns of case ascertainment and trends in meningococcal disease in England and Wales. Commun Dis Rep CDR Rev. 1997;7:R49-R54.
3. Committee on Infectious Disease of the American Academy of Pediatrics. Meningococcal disease prevention and control strategies for practice-based physicians. Pediatrics. 1996;97:404-441.
4. Amato NV, Finger H, Gotschlich EC, et al. Serologic response to serogroup C meningococcal vaccine in Brazilian preschool children. Rev Inst Med Trop Sao Paulo. 1974;16:149-153.
5. Peltola HA, Safary A, Kayhty H, et al. Evaluation of 2 tetravalent (ACY W 135) meningococcal vaccines in infants and small children: a clinical study comparing immunogenicity of 0-acetyl-negative and 0-acetyl-positive serogroup C polysaccharides. Pediatrics. 1985;76:91-96.
6. Gold R, Lepow ML, Goldschneider I, et al. Kinetics of antibody production to group A and group C meningococcal polysaccharide vaccines administered during the first six years of life: prospects for routine immunization of infants and children. J Infect Dis. 1979;140:690-697.
7. King WJ, MacDonald NE, Wells G, et al. Total and functional antibody response to a quadrivalent meningococcal vaccine among children. J Pediatr. 1996;128:196-202.
8. Gold R, Lepow ML, Goldschneider I, Gotschlich EC. Immune response of human infants to polysaccharide vaccines of group A and C Neisseria meningitidis. J Infect Dis. 1977;136(suppl):S31-S35.
9. Leach A, Twumasi PA, Kumah S, et al. Induction of immunologic memory in Gambian children by vaccination in infancy with a group A plus group C meningococcal polysaccharide protein conjugate vaccine. J Infect Dis. 1997;175:200-204.
10. Fairley CK, Begg N, Borrow R, Fox AJ, Jones DM, Cartwright K. Conjugate meningococcal serogroup A and C vaccine: reactogenicity and immunogenicity in United Kingdom infants. J Infect Dis. 1996;174:1360-1363.
11. Lieberman JM, Chiu SS, Wong VK, et al. Safety and immunogenicity of a serogroup A/C Neisseria meningitidis oligosaccharide-protein conjugate vaccine in young children: a randomized trial. JAMA. 1996;275:1499-1503.
12. Granoff DM, Kelsey SK, Bijlmer HA, et al. Antibody responses to capsular polysaccharide of Neisseria meningitidis serogroup B in patients with meningococcal disease. Clin Diagn Lab Immunol. 1995;2:574-582.
13. Granoff DM, Bartoloni A, Ricci S, et al. A modified enzyme-linked immunoabsorbent assay for measurement of antibody responses to meningococcal C polysaccharide that correlates with bactericidal responses. Clin Diagn Lab Immunol. 1998;5: 479-485
14. Granoff DM, McHugh YE, Raff HV, Mokatrin AS, Van Nest GA. MF 59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM 197 conjugate vaccine. Infect Immun. 1997;65:1710-1715.
15. Mandrell RE, Azmi FH, Granoff DM. Complement-mediated bactericidal activity of human antibodies to poly-alpha-2-8-N-acetylneuramic acid, the capsular polysaccharide of Neisseria meningitidis serogroup B. J Infect Dis. 1995;172:1279-1289.
16. Goklschneider I, Gotschlich EC, Artenstein MS. Human immunity to the meningococcus, 1: the role of humoral antibodies. J Exp Med. 1969;129:1307-1326.
17. Goldschneider I, Lepow ML, Gotschlich EC, Mauck FT, Bachl F, Randolph M. Immunogenicity of group A and group C meningococcal polysaccharides in human infants. J Infect Dis. 1973;128:769-776.
18. Granoff DM, Gupta RK, Belshe RB, Anderson EL. Induction of immunologic refractoriness in adults by meningococcal C polysaccharide vaccination. J Infect Dis. 1998;178:870-874.
19. Hume SE. Mass voluntary immunization campaigns for meningococcal disease in Canada: media hysteria. JAMA. 1992;267:1833-1838.
20. Robbins JB, Schneerson R, Anderson P, Smith DH. The 1996 Albert Lasker Medical Research Awards: prevention of systemic infections, especially meningitis, caused by Haemophilus influenzae type b: impact on public health and implications for other polysaccharide-based vaccines. JAMA. 1996;276:1181-1185.
21. MacLennan J, Shackley F, Health P, et al. Induction of immunologic memory by a Neisseria meningitidis group C conjugate vaccine. Paper presented at: 15th Annual Meeting of the European Society for Paediatric Infections; May 21-23, 1997; Paris, France.
22. Takala AK, Eskola J, Leinonen M, et al. Reduction of oropharyngeal carriage of Haemophilus influenzae type B (Hib) in children immunized with an Hib conjugate vaccine. J Infect Dis. 1991;164:982-986.
23. King WJ, MacDonald NE, Wells G, Manion D, Allen U. Relationship between parental occupation and children's oropharyngeal colonization with Neisseria meningitidis. J Pediatr. 1995;126:937-939.