Anti-AIDS agents 33.1 Synthesis and anti-HIV activity of mono-methyl substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 16, 1998, Pages 2151-2156

  Xie, Lan ^a   Takeuchi, Yasuo ^a   Cosentino, L Mark ^b   Lee, Kuo Hsiung ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b BBI Biotech Research Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYL 3',4' DI O CAMPHANOYL KHELLACTONE; 4 METHYL 3',4' DI O CAMPHANOYL KHELLACTONE; 5 METHYL 3',4' DI O CAMPHANOYL KHELLACTONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; KHELLACTONE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOID CELL LINE; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE; VIRUS INHIBITION;

ANTI-HIV AGENTS; CAMPHOR; CELL LINE; DRUG DESIGN; HIV-1; HUMANS; INDICATORS AND REAGENTS; ISOMERISM; LYMPHOCYTES; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0032544137     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00367-9     Document Type: Article

References (13)

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9. 2-PYR: Hydroquinine 2,5-diphenyl-4,6-pyrimidinediyl diether.
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11. 1H NMR analysis of the bis-(-)-camphanic esters.
12. 2O: Theory: C, 64.21; H, 6.47. Found: C, 64.47; H, 6.39.
13. 2 for 4 days. Cell-free supernatants were collected on Day 4 for use in our in-house p24 antigen ELISA assay. P24 antigen is a core protein of HIV and therefore is an indirect measure of virus present in the supernatants. Toxicity was determined by performing cell counts by a Coulter Counter on the mock-infected H9 cells that had either received culture medium (no toxicity) or test sample or AZT.