Anti-AIDS agents - XXVIII. Synthesis and anti-HIV activity of methoxy substitute 3',4'-di-O-(-)-Camphanoyl-(+)-cis-Khellactone (DCK) analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 20, 1997, Pages 2573-2578

  Takeuchi, Yasuo ^a   Xie, Lan ^a   Cosentino, L Mark ^b   Lee, Kuo Hsiung ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b Biotech Research Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; KHELLACTONE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOCYTE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

EID: 0030725569     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10050-6     Document Type: Article

References (11)

1. For Anti-AIDS Agents 27. Hashimoto, F.; Kashiwada, Y.; Cosentino, L. M.; Chen, C. H.; Garrett, P. E.; Lee, K. H. Bioorg. Med. Chem. in press.
2. Lee, T. T.; Kashiwada, Y.; Huang, L.; Snider, J.; Cosentino, L. M.; Lee, K. H. Bioorg. Med. Chem. 1994, 2, 1051.
3. Huang, L.; Kashiwada, Y.; Cosentino, L. M.; Fan, S.; Chen, C.; McPhail, A. T.; Fujioka, T.; Mihashi, K.; Lee, K. H. J. Med. Chem. 1994, 37, 3947.
4. Huang, L.; Kashiwada, Y.; Cosentino, L. M.; Fan, S.; Lee, K. H. Bioorg. Med. Chem. Lett. 1994, 4, 593.
5. Ahluwalia, V. K.; Kumar, D. Indian J. Chem. 1977, 15B, 945.
6. Hlubuek, J.; Ritchie, E.; Taylor, W. C. Aust. J. Chem. 1971, 62, 2347.
7. Xie, L.; Crimmins, M. T.; Lee, K. H. Tetrahedron Lett. 1995, 56, 4529.
8. 2-PYR: Hydroquinine 2,5-diphenyl-4,6-pyrimidinediyl diether.
9. 2O: Theory: C, 60.25; H, 6.50. Found: C, 60.22; H, 6.92.
10. 1H NMR analysis of the bis-(-)-camphanic esters.
11. 2 for 4 days. Cell-free supernatants were collected on Day 4 for use in our in-house p24 antigen ELISA assay. P24 antigen is a core protein of HIV and therefore is an indirect measure of virus present in the supernatants. Toxicity was determined by performing cell counts by a Coulter Counter on the mock-infected H9 cells which had either received culture medium (no toxicity) or test sample or AZT.