Probing the non-mevalonate pathway to phytol in the cyanobacterium Synechocystis sp. UTEX 2470 using deuterium-labeled glucose

Tetrahedron Letters

Volumn 39, Issue 51, 1998, Pages 9373-9376

  Proteau, Philip J ^a  

^a OREGON STATE UNIVERSITY   (United States)

Author keywords

Biosynthesis; Isoprenoids; Labelling; Terpenes and terpenoids

Indexed keywords

DEUTERIUM; GLUCOSE; PHYTOL; TERPENE DERIVATIVE;

ARTICLE; CYANOBACTERIUM; DRUG SYNTHESIS; ISOTOPE LABELING;

EID: 0032542199     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02113-3     Document Type: Article

References (14)

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6. 6) Isopentenyl diphosphate is the endpoint metabolite of the mevalonate pathway which can be isomerized to dimethylallyl diphosphate (DMAPP). It is not known at this time whether IPP, DMAPP, or both are the true end metabolites of the non-mevalonate pathway.
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8. 8) The growth conditions and procedures for isolation of phytol are as described in ref. 3.
9. 1
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12. + upon formation of BPG, then deuterium may or may not be transferred back to G3P at a later stage. This would increase the C1:C4 ratio of deuterium labels seen in the phytol product.
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