Synthesis and activity studies of N-[ω-N'-(adamant-1'-yl)aminoalkyl]-2-(4'-dimethylaminophenyl)acetamides: In the search of selective inhibitors for the different molecular forms of acetylcholinesterase

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 6, 1998, Pages 575-580

  Perola, Emanuele ^a   Cellai, Luciano ^a   Brufani, Mario ^b  

^a CNR   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINESTERASE INHIBITOR; PHYSOSTIGMINE;

ALZHEIMER DISEASE; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANIMALS; BRAIN; CATALYTIC DOMAIN; CATTLE; CHOLINESTERASE INHIBITORS; ERYTHROCYTES; HUMANS; PROTEIN CONFORMATION; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TORPEDO;

EID: 0032539939     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00076-6     Document Type: Article

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