Anti-AIDS agents 31. Synthesis and anti-HIV activity of 4-substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) thiolactone analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 12, 1998, Pages 1483-1486

  Yang, Zheng Yu ^a   Xia, Yi ^a   Xia, Peng ^a   Cosentino, L Mark ^b   Lee, Kuo Hsiung ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b Biotech Research Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 BENZYL 3',4' DI O CAMPHANOYLKHELTHIOLACTONE; 4 H 3',4' DI O CAMPHANOYLKHELTHIOLACTONE; 4 METHYL 3',4' DI O CAMPHANOYLKHELTHIOLACTONE; 4 PHENYL 3',4' DI O CAMPHANOYLKHELTHIOLACTONE; ANTIVIRUS AGENT; SUKSDORFIN; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG ISOLATION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELL LINE; HIV-1; HUMANS; LACTONES; LYMPHOCYTES; STRUCTURE-ACTIVITY RELATIONSHIP; THIONES; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0032537576     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00254-6     Document Type: Article

References (10)

1. 1. For Part 30, see Kashiwada, Y.; Wang, H. K.; Nagao, T.; Kitanaka, S.; Yasuda, I.; Fujioka, T.; Yamagishi, T.; Cosentino, L. M.; Kozuka, M.; Okabe, H.; Ikeshiro, Y.; Hu, C. Q.; Yeh, E.; Lee, K. H. J. Nat. Prod., in press.
2. 2. Lee, T. T.; Kashiwada, Y.; Huang, L.; Snider, J.; Cosentino, L. M.; Lee, K. H. Bioorg. Med. Chem. 1994, 2, 1051.
3. 3. Huang, L.; Kashiwada, Y.; Cosentino, L. M.; Fan, S.; Chen, C.; McPhail, A. T.; Fujioka, T.; Mihashi, K.; Lee, K. H. J. Med. Chem. 1994, 37, 3947.
4. 4. Huang, L.; Kashiwada, Y.; Cosentino, L. M.; Fan, S.; Lee, K. H. Bioorg. Med. Chem. Lett. 1994, 4, 593.
5. 5. Takeuchi, Y.; Xie, L.; Cosentino, L. M.; Lee, K. H. Bioorg. Med. Chem. Lett. 1997, 7, 2573.
6. 6. Xie, L.; Crimmins, M. T.; Lee, K. H. Tetrahedron Lett. 1995, 36, 4529.
7. 10S 714.2498, Found 714.2489.
8. 1H NMR analysis of the bis-(-)-camphanic esters.
9. 5
10. 10. Xie, L.; Takeuchi, Y.; Cosentino, L. M.; Lee, K. H. Bioorg. Med Chem. Lett, submitted