The use of neamine as a molecular template: Identification of active site residues in the bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa by mass spectroscopy

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 24, 1998, Pages 3489-3494

  Yang, Yi ^a   Roestamadji, Juliatiek ^b   Mobashery, Shahriar ^b   Orlando, Ron ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE 3' PHOSPHOTRANSFERASE 2A; AMINOGLYCOSIDE ANTIBIOTIC AGENT; BACTERIAL ENZYME; ENZYME INHIBITOR; NEAMINE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME INHIBITOR INTERACTION; INHIBITION KINETICS; MASS SPECTROMETRY;

ASPARTIC ACID; BINDING SITES; DRUG RESISTANCE, MICROBIAL; GLUTAMIC ACID; KANAMYCIN KINASE; MOLECULAR PROBES; NEOMYCIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

BACTERIA (MICROORGANISMS);

EID: 0032535506     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00634-9     Document Type: Article

References (8)

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