Relationship between patient variables and plasma clozapine concentrations: A dosing nomogram

Biological Psychiatry

Volumn 44, Issue 8, 1998, Pages 733-738

  Perry, Paul J ^a,b   Bever, Kristine A ^a   Arndt, Stephan ^a   Combs, Michael D ^b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Clozapine; Concentration; Dosing; Nomogram; Plasma; Schizophrenia

Indexed keywords

CLOZAPINE;

ADULT; ARTICLE; DRUG BLOOD LEVEL; DRUG MONITORING; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NOMOGRAM; ORTHOSTATIC HYPOTENSION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHIZOIDISM; SCHIZOPHRENIA; SEDATION; SEX DIFFERENCE; SIDE EFFECT; SMOKING; STEADY STATE;

ADULT; ANTIPSYCHOTIC AGENTS; CLOZAPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MODELS, PSYCHOLOGICAL; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEX CHARACTERISTICS; SMOKING;

EID: 0032532712     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(97)00531-3     Document Type: Article

References (17)

1. Byerly M., DeVane C.L. Pharmacokinetics of clozapine and risperidone A review of recent literature . J Clin Psychopharmacol. 16:1996;177-187.
2. Centorrino F., Baldessarini R.J., Kando J.C., Frankenburg F.R., Volpicelli S.A., Flood J.G. Clozapine and metabolites Concentrations in serum and clinical findings during treatment of chronically psychotic patients . J Clin Psychopharmacol. 14:1994;119-125.
3. Haring C., Meise U., Humpel C., Saria A., Fleischhacker W.W., Hinterhuber H. Dose-related plasma levels of clozapine Influence of smoking behavior, sex and age . Psychopharmacology. 99:1989;S38-S40.
4. Hasegawa M., Gutierrez-Esteinou R., Way L., Meltzer H.Y. Relationship between clinical efficacy and clozapine concentrations in plasma in schizophrenia Effect of smoking . J Clin Psychopharmacol. 13:1993;383-390.
5. Jann M.W., Grimsley S.R., Gray E.C., Change W.H. Pharmacokinetics and pharmacodynamics of clozapine. Clin Pharmacokinet. 24:1993;161-176.
6. Kane J.M., Honigfeld G., Singer J., Meltzer H. Clozapine for the treatment-resistant schizophrenic. Arch Gen Psychiatry. 45:1988;789-796.
7. Kronig M.H., Munne R.A., Szymanski S., Safferman A.Z., Pollack S., Cooper T., et al. Plasma clozapine levels and clinical response for treatment-refractory schizophrenic patients. Am J Psychiatry. 152:1995;179-182.
8. Lieberman J.A., Kane J.M., Johns C.A. Clozapine Guidelines for clinical management . J Clin Psychiatry. 50:1989;329-338.
9. Lovdahl M.J., Perry P.J., Miller D.D. The assay of clozapine and n-desmethylclozapine in human plasma by high-performance liquid chromatography. Ther Drug Monit. 13:1991;69-72.
10. Meltzer H.Y., Bastani B., Ramirez L., Matsubara S. Clozapine New research on efficacy and mechanism of action . Eur Arch Psychiatr Neural Sci. 238:1989;332-339.
11. Miller D.D., Perry P.J., Cadoret R.J., Andreasen N.C. Clozapine's effect on negative symptoms in treatment-refractory schizophrenics. Compr Psychiatry. 35:1994;8-15.
12. Olesen O.V., Thomsen K., Jensen P.N., Wulff C.H., Rasmussen N.A., Refshammer C., et al. Clozapine New research on efficacy and mechanism of action . Eur Arch Psychiatr Neural Sci. 238:1989;332-339.
13. Perry P.J., Miller D.D. The clinical utility of clozapine plasma concentrations. Marder S.R., Davis J.M., Janicak P.M. Clinical Use of Neuroleptic Plasma Levels. 1993;85-100 American Psychiatric Press, Washington, DC.
14. Perry P.J., Miller D.D., Arndt S.V., Cadoret R.J. Clozapine and norclozapine plasma concentrations and clinical response in treatment-refractory schizophrenics. Am J Psychiatry. 148:1991;231-235.
15. Potkin S.G., Bera R., Gulasekaram B., Costa J., Hares S., Jin Y., et al. Plasma clozapine concentrations predict clinical response in treatment-resistant schizophrenia. J Clin Psychiatry. 55:(suppl B):1994;133-138.
16. Rowland M., Tozer T.N. Clinical Pharmacokinetics Concepts and Applications . 3rd ed. 1995;Williams and Wilkins, Baltimore.
17. VanderZwaag C., McGee M., McEvoy J.P., Freudenreich O., Wilson W.H., Cooper T.B. Response of patients with treatment-refractory schizophrenia to clozapine within three serum level ranges. Am J Psychiatry. 153:1996;1579-1584.