Agonist-induced down-regulation of the β2-adrenoceptor and its mRNA in human mononuclear leukocytes

Biochemical Pharmacology

Volumn 56, Issue 8, 1998, Pages 967-975

  Tittelbach, Viola ^a   Volff, Jean Nicolas ^a   Giray, Jeanette ^a   Ratge, Dieter ^a   Wisser, Hermann ^a  

^a ROBERT BOSCH HOSPITAL   (Germany)

Author keywords

2 adrenoceptor; 2 adrenoceptor mRNA; Mononuclear leukocytes

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; BETA 2 ADRENERGIC RECEPTOR; CYANOPINDOLOL I 125; ISOPRENALINE; MESSENGER RNA; PROPRANOLOL; RECEPTOR PROTEIN;

ADULT; ANIMAL CELL; ARTICLE; HUMAN; HUMAN EXPERIMENT; MALE; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADRENERGIC BETA-AGONISTS; ADULT; DOWN-REGULATION; HALF-LIFE; HUMANS; ISOPROTERENOL; LEUKOCYTES, MONONUCLEAR; MALE; POLYMERASE CHAIN REACTION; RECEPTORS, ADRENERGIC, BETA-2; REFERENCE VALUES; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; TRANSCRIPTION, GENETIC;

EID: 0032531842     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00231-7     Document Type: Article

References (43)

1. Hadcock J.R., Malbon C.C. Down-regulation of beta-adrenergic receptors Agonist-induced reduction in receptor mRNA levels . Proc Natl Acad Sci USA. 85:1988;5021-5025.
2. Lohse M.J. Molecular mechanisms of membrane receptor desensitization. Biochim Biophys Acta. 1179:1993;171-188.
3. 2-adrenergic receptor. J Biol Chem. 264:1989;16786-16792.
4. Hadcock J.R., Ros M., Malbon C.C. Agonist regulation of beta-adrenergic receptor mRNA. Analysis in S49 mouse lymphoma mutants. J Biol Chem. 264:1989;13956-13961.
5. Mak J.C., Nishikawa M., Shirasaki H., Miyayasu K., Barnes P.J. Protective effects of a glucocorticoid on down-regulation of pulmonary beta 2-adrenergic receptors in vivo. J Clin Invest. 96:1995;99-106.
6. 1 receptor messenger RNA abundance in the failing human heart. J Clin Invest. 92:1993;2737-2745.
7. 1-adrenergic receptors in the failing human heart. Circulation. 87:1993;454-463.
8. Brodde O.-E., Beckeringh J.J., Michel M.C. Human heart β-adrenoceptors A fair comparison with lymphocyte β-adrenoceptors? TIPS. 8:1987;403-407.
9. Brodde O.-E., Michel M.C., Gordon E.P., Sandoval A., Gilbert E.M., Bristow M.R. Beta-adrenoceptor regulation in the human heart Can it be monitored in circulating lymphocytes? Eur Heart J. 10:(suppl B):1989;2-10.
10. Haen E. The peripheral lymphocyte as clinical model for receptor disturbance Asthmatic disease . Bull Eur Physiopathol Respir. 23:1987;539-541.
11. Brodde O.-E. Die Rolle adrenerger alpha und beta-Rezeptoren in der Pathogenese von Hypertonie und Herzerkrankungen. Internist. 29:1988;397-413.
12. Mancini D.M., Martin J.F., Fischberg D., Molinoff P.B., Wilson J.R. Characterization of lymphocyte beta-adrenergic receptors at rest and during exercise in ambulatory patients with chronic congestive heart failure. Am J Cardiol. 63:1989;307-312.
13. Young J.W., Steinman R.M. Accessory cell requirements for the mixed leukocyte reaction and polyclonal mitogens, as studied with a new technique for enriching blood dendritic cells. Cell Immunol. 111:1988;167-182.
14. Scatchard G. The attraction of proteins for small molecules and ions. Ann NY Acad Sci. 51:1949;660-672.
15. 2-receptor messenger RNA in human heart. Eur J Clin Chem Biochem. 34:1996;411-417.
16. Marsh J.L., Erfle M., Wykes E.J. The pIC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation. Gene. 32:1984;481-485.
17. Marchuk D., Drumm M., Saulino A., Collins F.S. Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products. Nucleic Acids Res. 19:1990;1154.
18. Yanisch-Perron C., Vieira J., Messing J. Improved M13 phage cloning vectors and host strains Nucleotide sequences of the M13mp18 and pUC19 vectors . Gene. 33:1995;103-119.
19. Hanahan D. Studies on transformation of Escherichia coli with plasmids. J Mol Biol. 166:1983;557-580.
20. Chung C.T., Niemela S.L., Miller R.H. One-step preparation of competent Escherichia coli Transformation and storage of bacterial cells in the same solution . Proc Natl Acad Sci USA. 86:1989;2172-2175.
21. Sambrook J, Fritsch EF and Maniatis T, Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor NY, 1989.
22. Qiagen Plasmid Handbook. Qiagen, Hilden, 1993.
23. Price T., Aitken J., Head J., Mahendroo M., Means G., Simpson E. Determination of aromatase cytochrome P450 messenger ribonucleic acid in human breast tissue by competitive polymerase chain reaction amplification. J Clin Endocrin Metab. 74:1992;1247-1252.
24. Becker-André M., Hahlbrock K. Absolute mRNA quantification using the polymerase chain reaction (PCR). A novel approach by a PCR aided transcript titration assay (PATTY). Nucleic Acids Res. 17:1989;9437-9446.
25. Rodgers J.R., Johnson M.L., Rosen J.M. Measurement of mRNA concentration and mRNA half-life as a function of hormonal treatment. Methods Enzymol. 109:1985;572-592.
26. 2-adrenoceptors in intact human lymphocytes. Arch Int Pharmacodyn Ther. 272:1984;24-39.
27. DeBlasi A., Maisel A.S., Feldman R.D., Ziegler M.G., Fratelli M., DiLallo M., Smith D.A., Lai C.C., Motulsky H.J. In vivo regulation of β-adrenergic receptors on human mononuclear leucocytes. Assessment of receptor number, location, and function after posture change, exercise, and isoproterenol infusion. J Clin Endocrin Metab. 63:1986;847-853.
28. 2-adrenoceptor gene in human mononuclear leucocytes by in situ hybridization with fluorochrome-labeled cloned DNA. J Recept Res. 11:1991;473-482.
29. Insel P.A. Adrenergic receptors Evolving concepts and clinical implications . N Engl J Med. 334:1996;580-585.
30. Dangel V., Giray J., Ratge D., Wisser H. Regulation of β-adrenoceptor density and mRNA levels in the rat heart cell line H9c2. Biochem J. 317:1996;925-931.
31. 1-adrenergic receptor mRNA in heart failure . J Am Coll Cardiol. 27:1996;146-154.
32. Borst MM, Schwencke C, Beuthien W, La Rosée P, Marquetant R and Strasser RH, Downregulation pulmonaler β-adrenerger Rezeptoren in der Herzinsuffizienz: eine mögliche Ursache des "Asthma cardiale"? Z Kardiol84 (suppl 1), 28, 1995.
33. 2-Adrenozeptoren bei Herzinsuffizienz. Z Kardiol 81 (suppl 4), 71-78, 1992.
34. Steinfath M., Lavicky J., Schmitz W., Scholz H., Doring V., Kalmar P. Changes in cardiac beta-adrenoceptors in human heart diseases Relationship to the degree of heart failure and further evidence for etiology-related regulation of beta 1 and beta 2 subtypes . J Cardiothorac Vasc Anesth. 7:1993;668-673.
35. Summers R.J., McMartin L.R., Kompa A., Molenaar P. Signalling pathways in cardiac failure. Clin Exp Pharmacol Physiol. 22:1995;874-876.
36. Ratge D., Wiedemann A., Kohse K.P., Hellberg K., Wisser H. Magnitude and kinetics of alterations in plasma catecholamines and leukocyte β-adrenergic receptors in response to anaesthesia and surgery. J Clin Chem Clin Biochem. 28:1990;391-398.
37. Smiley R.M., Pantuck C.B., Chadburn A., Knowles D.M. Down-regulation and desensitization of the beta-adrenergic receptor system of human lymphocytes after cardiac surgery. Anesth Analg. 77:1993;653-661.
38. Hadcock J.R., Wang H.-Y., Malbon C.C. Agonist-induced destabilization of β-adrenergic receptor mRNA. J Biol Chem. 264:1989;19928-19933.
39. Hosoda K., Fitzgerald L.R., Vaidya V.A., Feussner G.K., Fishman P.H., Duamn R.S. Regulation of beta-2-adrenergic receptor mRNA and gene transcription in rat C6 glioma cells Effects of agonist, forskolin and protein synthesis inhibition . Mol Pharmacol. 48:1995;206-211.
40. Collins S., Quarmby V.E., French F.S., Lefkowitz R.J., Caron M.G. Regulation of the beta2-adrenergic receptor and its mRNA in the rat ventral prostate by testosterone. FEBS Lett. 233:1988;173-176.
41. 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP. J Biol Chem. 265:1990;19330-19335.
42. Emorine L.J., Marullo S., Delavier-Klutchko C., Kaveri S.V., Durieu-Trautmann O., Strosberg A.D. Structure of the gene for human beta2-adrenergic receptor expression and promoter characterization. Proc Natl Acad Sci USA. 84:1987;6995-6999.
43. Morris B.J. Control of receptor sensitivity at the mRNA level. Mol Neurobiol. 7:1993;189-205.