Human integrin β3 gene expression: Evidence for a megakaryocytic cell- specific cis-acting element

Blood

Volumn 92, Issue 8, 1998, Pages 2777-2790

  Jin, Ying ^b   Wilhide, Calvin C ^b   Dang, Chi ^b   Li, Lu ^b   Li, Su Xia ^b   Villa Garcia, Manuel ^b   Bray, Paul F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; INTEGRIN; BETA3 INTEGRIN; FIBRINOGEN RECEPTOR; HYBRID PROTEIN; LEUKOCYTE ANTIGEN; TRANSCRIPTION FACTOR SP1;

ARTICLE; GENE ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENE STRUCTURE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MEGAKARYOCYTE; PRIORITY JOURNAL; ANIMAL; ANTIBODY SPECIFICITY; BIOSYNTHESIS; CELL CULTURE; CHO CELL; COMPARATIVE STUDY; CRICETULUS; DRUG EFFECT; ENDOTHELIUM; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; HEMATOPOIETIC STEM CELL; MELANOMA; METABOLISM; PATHOLOGY; PHYSIOLOGY; REGULATORY SEQUENCE; REPORTER GENE;

ANIMALS; ANTIGENS, CD; CHO CELLS; CRICETINAE; CRICETULUS; ENDOTHELIUM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; HEMATOPOIETIC STEM CELLS; HUMANS; INTEGRIN BETA3; MEGAKARYOCYTES; MELANOMA; ORGAN SPECIFICITY; PLATELET MEMBRANE GLYCOPROTEINS; RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE DELETION; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0032531432     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.8.2777     Document Type: Article

References (88)

1. Hynes RO: Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 69:11, 1992
2. Bray P, Shuman M: Identification of an abnormal gene for the GPIIIa subunit of the platelet fibrinogen receptor resulting in Glanzmann's thrombasthenia. Blood 75:881, 1990
3. Bray P: Inherited diseases of platelet glycoproteins: Considerations for rapid molecular characterization. Thromb Haemost 71:1383, 1994
4. 3integrin genes during megakaryocytic differentiation of pluripotential K562 cells, J Bio Chem 267:20233, 1992
5. Silver S, McDonough M, Vilaire G, Bennett J: The in vitro synthesis of polypeptides for the platelet membrane glycoproteins IIb and IIIa. Blood 69:1031, 1987
6. Lessey B, Damjanovich L, Coutifaris C: Integrin adhesion molecules in the human endometrium: Correlation with the normal and abnormal menstrual cycle. J Clin Invest 90:188, 1992
7. Lessey B, Lie Y, Castelbaum A, Yowell C, Buck C, Sun J: Further characterization of endometrial i me grin s during the menstrual cycle and in pregnancy. Fertil Steril 62:497, 1994
8. Yuan L, Bray P, Young S, Lessey B: Estrogen, progesterone and EGF action on the human β3 integrin promoter: Implications for the establishment of endometrial receptivity. Soc Gynecol Invest 42:0-4a, 1996
9. 3 integrin complex on human microvascular endothelial cells. J Invest Derm 103:295, 1994
10. Cao X, Ross F, Zhang L, MacDonald P, Chappel J, Teitelbaum S: Cloning of the promoter for the avian integrin β3 subunit gene and its regulation by 1,25-dihydroxyvitamin D3. J Biol Chem 268:27371, 1993
11. 3: Transcriptional activation of the beta 3 but not the av gene. J Cell Biochem 62:467, 1996
12. Taniguchi Y, Komatsu N, Moriuchi T: Overexpression of the HOX4A (HOXD3) homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties. Blood 85:2786, 1995
13. 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79:1157, 1994
14. Klein S, Giancotti FG, Presta M, Albelda SM, Buck CA, Rifkin DB: Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells. Mol Biol Cell 4:937, 1993
15. Cao X, Teitelbaum S, Zhu H-J, Zhang L, Feng X, Ross F: Competition for a unique response element mediates retinoic acid inhibition of vitamin D3-stimulated transcription. J Biol Chem 271: 20650, 1996
16. Fong A, Santoro S: Transcriptional regulation of ant, integrin gene expression during megakaryocytic differentiation of K562 cells. J Biol Chem 269:18441, 1994
17. Lemarchandel V, Ghysdael J, Mignotte V, Rahuel C, Romeo PH: GATA and Ets cis-acting sequences mediate megakaryocyte-specific expression. Mol Cell Biol 13:668, 1993
18. Martin F, Prandini M-H, Thevenon D, Marguerie G, Uzan G: The transcription factor GATA-1 regulates the promoter activity of the platelet glycoprotein lib gene. J Biol Chem 268:21606, 1993
19. Prandini M, Denarier E Frachet P, Uzan G, Marguerie G: Isolation of the human platelet glycoprotein lib gene and characterization of the 5′ flanking region. Biochem Biophys Res Commun 156:595, 1988
20. Prandini M-H, Uzan G, Martin F: Characterization of a specific erythromegakaryocytic enhancer within the glycoprotein lib promoter. J Biol Chem 267:10370, 1992
21. Prandini M, Martin F, Thevenon D, Uzan G: The tissue-specific transcriptional regulation of the megakaryocytic glycoprotein lib gene is controlled by interactions between a represser and positive cis-acting elements. Blood 88:2062, 1996
22. Romeo P, Prandini M, Joulin V, Mignotte V, Prenant M, Vainchenker W, Marguerie G, Uzan G: Megakaryocytic and erythrocytic lineages share specific transcription factors. Nature 344:447, 1990
23. Uzan G, Prenant M, Prandini M, Martin F, Marguerie G: Tissue-specific expression of the platelet GpIIb gene. J Biol Chem 266:8932, 1991
24. Uzan G, Prandini M, Berthier R: Regulation of gene transcription during the differentiation of megakaryocytes. Thromb Haemost 74:210, 1995
25. IIb gene appears to stabilize Sp1 binding and is essential for expression of this TATA-less gene. Blood 88:2071, 1996
26. Doubeikovski A, Uzan G, Doubeikovski Z, Prandini M, Porteu F, Gisselbrecht S, Dusanter-Fourt I: Thrombopoietin-induced expression of the glycoprotein IIb gene involves the transcription factor PU.1/Spi-1 in UT7-Mpl cells. J Biol Chem 272:24300, 1997
27. Suda T, Takahashi N, Martin T: Modulation of osteoclast differentiation. Endocr Rev 13:6680, 1992
28. Bray P, Rosa J-P, Johnston G, Shiu D, Cook R, Lau C, Kan Y: Platelet glycoprotein IIb: Chromosomal location and tissue expression. J Clin Invest 80:1812, 1987
29. Fitzgerald L, Steiner B, Rall SJ, Lo S-S, Phillips D: Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone, J Biol Chem 262:3939, 1987
30. Davies J, Warwick J, Totty N, Philp R, Helfrich M, Horton M: The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol 109:1817, 1989
31. Vanderpuye O, Labarrere C, McIntyre J: A vitronectin-receptor-related molecule in human placental brush border membranes. Biochem J 280:9, 1991
32. Fadok V, Savill J, Haslett C, Bratton D, Doherty D, Campbell P, Henson P: Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J Immunol 149:4029, 1992
33. Savill J, Dransfield I, Hogg N, Haslett C: Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 343:170, 1990
34. Savill J, Hogg N, Ren Y, Haslett C: Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J Clin Invest 90:1532, 1992
35. v integrin subunit. J Biol Chem 266:18593, 1991
36. Stomski F, Gani J, Bates R, Burns G: Adhesion to thrombospondin by human embryonic fibroblasts is mediated by multiple receptors and includes a role for glycoprotein 88 (CD36). Exp Cell Res 198:85, 1992
37. Nesbit M, Herlyn M: Adhesion receptors in human melanoma progression. Invasion Metastasis 14:131, 1994
38. x) is responsible for distinct adhesive properties of carcinoma cells. Cell 57:59, 1989
39. Sonnenberg A, Modderman P, Hogerverst F: Laminin receptor on platelets is the integrin VLA-6. Nature 336:487, 1988
40. 6 as a fibronectin-binding protein. J Biol Chem 267:5790, 1992
41. 6 in cell attachment to fibronectin: Heterologous expression of intact and secreted forms of the receptor. J Biol Chem 269:6940, 1994
42. 8. J Biol Chem 266:19650, 1991
43. von dem Borne A, Modderman P, Admiraal L, Nieuwenhuis H: PI platelet antibodies, the overall results, in Knapp W, Dorken B, Stein H, Gilks W, Schmidt R, von dem Borne A feds): Leucocyte Typing IV. New York, NY, Oxford, 1989, p 951
44. Bray P, Barsh G, Rosa J-P, Lou X, Magenis E, Shuman M: Physical linkage of the genes for platelet membrane glycoproteins lib and IIIa. Proc Natl Acad Sci USA 85:8683, 1988
45. Lou X, Bray P, Magenis E: Precise localization of the gene for platelet membrane glycoprotein lib to 17q21.32 using structural rearrangements of chromosome 17. Cytogonet Cell Genet 51:1036, 1989
46. 3 integrin gene. Blood 83:668, 1994
47. 3 gene is 63 kb and contains a 5′-UTR sequence regulating expression. Blood 90:3951, 1997
48. McEver R, Bennett E, Martin M: Identification of two structurally and functionally distinct sites on human platelet membrane glycoprotein IIb-IIIa using monoclonal antibodies. J Biol Chem 258: 5269, 1983
49. Newman P, McEver R, Doers M, Kunicki T: Synergistic action of two murine monoclonal antibodies that inhibit ADP-induced platelet aggregation without blocking fibrinogen binding. Blood 69:668, 1987
50. Gerwirtz A, Burger D, Rado T, Benz E, Hoffman R: Constitutive expression of platelet glycoproteins by the human leukemia cell line K562. Blood 60:785, 1982
51. Tabilio A, Pelicci P, Vinci G, Mannoni P, Civin C, Vainchenker W, Testa U, Lipinski M, Rochant H, Breton-Gorius J: Myeloid and megakaryocytic properties of K-562 cell lines. Cancer Res 43:4569, 1983
52. Greenberg S, Rosenthal D, Greeley T, Tantravahi R, Handin R: Characterization of a new megakaryocytic cell line: the Dami cell. Blood 72:1968, 1988
53. Tabilio A, Rosa J, Testa U, Kieffer N, Nurden T, Del Canizo M, Breton-Gorius J, Vainchenker W: Expression of platelet membrane glycoproteins and α-granule proteins by a human erythroleukemia cell line (HEL). EMBO J 3:453, 1984
54. Wilhide CC, van Dang C, Dipersio J, Kenedy AA, Bray PF: Overexpression of cyclin D1 in the Dami megakaryocytic cell line causes growth arrest. Blood 86:294, 1995
55. Swerlick R, Brown E, Xu Y, Kwang H, Manos S, Lawley T: Expression and modulation of the vitronectin receptor on human dermal microvascular entlothelial cells. J Invest Derm 92:715, 1992
56. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biol Chem 162:156, 1987
57. Kato G, Barrett J, Villa-Garcia M, Dang C: An amino terminal c-Myc domain required for neoplastic transformation activates transcription. Mol Cell Biol 10:5914, 1990
58. Wang W, Gralla J: Differential ability of proximal and remote element pairs to cooperate in activating RNA polymerase II transcription. Mol Cell Biol 11:4561, 1991
59. Andrews N, Faller D: A rapid micropreparation technique for extraction of DNA-binding protein from limiting numbers of mammalian cells. Nucleic Acids Res 19:2499, 1991
60. Hanzog G, Myers R: Discrimination among potential activators of the β-globin CACCC element by correlation of binding and transcriptional properties. Mol Cell Biol 13:44, 1993
61. Khachigian L, Fries J, Benz M, Bonthron D, Collins T: Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells. J Biol Chem 269:22647, 1994
62. Rao C, Pech M, Robbins K, Aaronson S: The 5′ untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor. Mol Cell Biol 8:284, 1988
63. Berg P, Mittlelman M, Elion J, Labie D, Sehechter A: Increased protein binding to α-530 mutation of the human β-globin gene associated with decreased β-globin synthesis. Am J Hematol 31:42, 1991
64. 2-integrin expression in human mammary epithelial cells. Mol Cell Biol 16:6178, 1996
65. Lopez-Rodriguez C, Chen HM, Tenen DG, Corbi AL: Identification of Sp1-binding sites in the CD11c (p150,95 alpha) and CD11a (LFA-1 alpha) integrin subunit promoters and their involvement in the tissue-specific expression of CD11c. Eur J Immunol 25:3496, 1995
66. Chen H, Pahl H, Scheibe R, Zhang D, Tenen D: The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity. J Biol Chem 268:8230, 1993
67. Kwiatkowski BA, Embree LJ, Ritchie KA, Hickstein DD: Human leukocyte integrin CD18 promoter directs low levels of expression of a mutated human CD4 reporter gene in leukocytes of transgenic mice. Biochem Biophys Res Commun 222:601, 1996
68. Kadonaga J, Jones K, Tijan R: Promoter-specific activation of RNA polymerase II transcription by Sp1. Trends Biochem Sci 11:20, 1986
69. Miller I, Bicker J: A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol Cell Biol 13:2776, 1993
70. D'Angelo D, Oliver B, Davis M, McCluskey T, Dorn G: Novel role for Sp1 in phorbul ester enhancement of human platelet thromboxane receptor gene expression. J Biol Chem 271:19696, 1996
71. Bieker J: Isolation, genomic structure, and expression of human erythroid Kruppel-like factor (EKLF). DNA Cell Biol 15:347, 1996
72. Perkins A, Sharpe A, Orkin S: Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature 375: 318, 1995
73. Lopez-Rodriguez C, Botella L, Corbi A: CCAAT-enhancerbinding proteins (C/EBP) regulate the tissue specific activity of the CD11c integrin gene promoter through functional interactions with Sp1 proteins. J Biol Chem 272:29120, 1997
74. Chen L, Nishinaka T, Kwan K, Kitabayashi I, Yokoyama K, Fu Y, Grunwald S, Chiu R: The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator. Mol Cell Biol 14:4380, 1994
75. Kim L, Yamada K: The regulation of expression of integrin receptors. Proc Soc Exp Biol Med 214:123, 1997
76. 1-integrin gene expression is regulated by two promoter regions. J Biol Chem 268:5148, 1993
77. 4 integrin subunit, DNA Cell Biol 13:743, 1994
78. Lopez-Cabrera M, Nueda A, Vara A, Garcia-Aguilar J, Tugores A, Corbi A: Characterization of the p 150, 95 leukocyte integrin alpha subunit (CD11c) gene promoter. Identification of cis-acting elements. J Biol Chem 268:1187, 1993
79. Rosmarin A, Levy R, Tenen D: Cloning and analysis of the CD18 promoter. Blood 79:2598, 1992
80. 2 integrin gene promoter. Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression. J Biol Chem 269:463, 1994
81. Audet J, Masson J, Rosen G, Salesse C, Guerin S: Multiple regulatory elements control the basal promoter activity of the human alpha 4 integrin gene. DNA Cell Biol 13:1071, 1994
82. 5 gene promoter. J Biol Chem 266:20544, 1991
83. Agura E, Howard M, Collins S: Identification and sequence analysis of the promoter for the leukocyte integrin beta-subunit (CD-18): Aretinoic acid-inducible gene. Blood 79:602, 1992
84. 2: integrin CD18 promoter consists of two inverted Ets cis elements. Mol Cell Biol 14:2604, 1994
85. 2 leukocyte integrin) promoter requires PU.1 transcription factor for myeloid activity. Proc Natl Acad Sci USA 92:801, 1995
86. Pahl H, Scheibe R, Zhang D, Chen H, Galson D, Maki R, Tenen D: The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter. J Biol Chem 268:5014, 1993
87. 4 integrin gene promoter. J Biol Chem 269:15652, 1994
88. Block K, Poncz M: Platelet glycoprotein IIb gene expression as a model of meg akaryocyte-specific expression. Stem Cells 13:135, 1995