Phorbol ester causes ligand-independent activation of the androgen receptor

European Journal of Biochemistry

Volumn 256, Issue 3, 1998, Pages 541-549

  Darne, Christian ^a   Veyssiere, Georges ^a   Jean, Claude ^a,b  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b CNRS   (France)

Author keywords

Androgen; C jun; MVDP; TPA; Transcriptional regulation

Indexed keywords

ANDROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; PHORBOL ESTER;

ARTICLE; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSCRIPTION REGULATION; TRANSGENE;

EID: 0032530494     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2560541.x     Document Type: Article

References (49)

1. Evans, R. M. (1988) The steroid and thyroid receptor superfamily, Science 240, 889-895.
2. Truss, M. & Beato, M. (1993) Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors, Endocr. Rev. 14, 459-479.
3. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P. & Evans, R. M. (1995) The nuclear receptor superfamily: the second decade, Cell 83, 835-839.
4. Hill, C. S. & Treisman, R. (1995) Transcription regulation by extracellular signals: mechanisms and specificity, Cell 80, 199-211.
5. Weigel, N. L. (1996) Steroid hormone receptors and their regulation by phosphorylation, Biochem. J. 319, 657-667.
6. Blok, L. J., De Ruiter, P. E. & Brinkmann, A. O. (1996) Androgen receptor phosphorylation, Endocr. Rev. 22, 197-219.
7. Kuiper, G. G. J. M. & Brinkmann, A. O. (1994) Steroid hormone receptor phosphorylation: is there or physiological role? Mol. Cell. Endocrinol. 100, 103-107.
8. Denner, L. A., Weigel, N. L., Maxwell, B. L., Schrader, W. T. & O'Malley, B. W. (1990) Regulation of progesterone receptor-mediated transcription by phosphorylation, Science 250, 1740-1743.
9. Power, R. F., Mani, S. K., Codina, J., Conneely, O. M. & O'Malley, B. W. (1991) Dopaminergic and ligand independent activation of steroid hormone receptors, Science 254, 1636-1639.
10. Smith, C. L., Conneely, O. M. & O'Malley, B. W. (1993) Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone, Proc. Natl Acad. Sci. USA 90, 6120-6124.
11. Ignar-Trowbridge, D., Teng, C., Ross, K. A., Parker, M. G., Korach, K. S. & McLachlan, J. A. (1993) Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-rcsponsivc element, Mol. Endocrinol. 7, 992-998.
12. Aronica, S. M. & Katzenellenbogen, B. S. (1991) Progesterone receptor regulation in uterine cells: stimulation by estrogen, cyclic adenosine 3′,5′-monophosphate, and insulin-like growth factor 1 and suppression by antiestrogens and protein kinase inhibitors, Endocrinology 128, 2045-2052.
13. Culig, Z., Hobish, A., Cronauer, M. V., Radmayr, C., Trapman, J., Hittmair, A., Bartsch, O. & Klocker, H. (1994) Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor I, keratinocyte growth factor, and epidermal growth factor, Cancer Res. 54, 5474-5478.
14. Nazareth, L. V. & Weigel, N. L. (1996) Activation of the human androgen receptor through a protein kinase A signaling pathway, J. Biol. Chem. 271, 19 900-19 907.
15. Ikonen, T., Palvimo, J. J., Kalhio, P. J., Reinikainen, P. & Jänne, O. A. (1994) Stimulation of androgen-regulated transactivation by modulators of protein phosphorylation, Endocrinology 135, 1359-1366.
16. De Ruiter, P. E., Teuwen, R., Trapman, J., Dijkema, R. & Brinkmann, A. O. (1995) Synergism between androgens and protein kinase-C on androgen-regulated gene expression, Mol. Cell. Endocrinol. 110, 121-126.
17. Beck, C. A., Weigel, N. J. & Edwards, D. P. (1992) Effects of hormone and cellular modulators of protein phosphorylation on transcriptional activity, DNA binding, and phosphorylation of human progesterone receptors, Mol. Endocrinol. 6, 607-620.
18. Mayer, M. L., Borror, K. L., Bona, B. J., De Franco, D. B. & Nordeen, S. K. (1993) Modulation of cell signaling pathways can enhance or impair glucocorticoid-induced gene expression without altering the state of receptor phosphorylation, J. Biol. Chem. 268, 22 933-22 940.
19. Nordeen, S. K., Mayer, M. L. & Bona, B. J. (1994) The coupling of multiple signal transduction pathways with steroid response mechanisms, Endocrinology 134, 1723-1732.
20. Cho, H. & Katzenellenbogen, B. S. (1993) Synergistic activation of estrogen receptor-mediated transcription by estradiol and protein kinase activators, Mol. Endocrinol. 7, 441-452.
21. Fabre, S., Darne, C., Veyssière, G. & Jean, C. (1996) Protein kinase C pathway potentiates androgen-mediated gene expression of the mouse vas deferens specific aldose reductase-like protein (MVDP), Mol. Cell. Endocrinol. 124, 79-86.
22. Reinikainen, P., Palvimo, J. J. & Jänne, O. A. (1996) Effects of mitogens on androgen receptor-mediated transactivation, Endocrinology 137, 4351-4357.
23. Pailhoux, E., Martinez, A., Veyssière, G. & Jean, C. (1990) Androgen-dependent protein from mouse vas deferens, cDNA cloning and protein homology with the aldo-keto reductase superfamily, J. Biol. Chem. 265, 19 932-19 936.
24. Taragnat, C., Berger, M. & Jean, C. (1988) Preliminary characterization, androgen-dependence and ontogeny of an abundant protein from mouse vas deferens, J. Reprod. Fertil. 83, 835-842.
25. Martinez, A., Pailhoux, E., Berger, M. & Jean, C. (1990) Androgen regulation of the mRNA encoding a major protein of the mouse vas deferens, Mol. Cell. Endocrinol. 72, 201-211.
26. Fabre, S., Manin, M., Pailhoux, E., Veyssière, G. & Jean, C. (1994) Identification of a functional androgen response element in the promoter of the gene for the androgen-regulated aldose reductase-like protein specific of the mouse vas deferens, J. Biol. Chem. 269, 5857-5864.
27. Darne, C., Morel, L., Ciaessens, F., Manin, M., Fabre, S., Veyssière, G., Rombauts, W. & Jean, C. (1997) Ubiquitous transcription factors NF1 and SP1 are involved in the androgen activation of the mouse vas deferens protein promoter, Mol. Cell. Endocrinol. 132, 13-23.
28. Luckow, B. & Schütz, G. (1987) CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements, Nucl. Acids Res. 15, 5490.
29. Cato, A. C. B., Henderson, D. & Ponta, H. (1987) The hormone response element of the mouse mammary tumor virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat region, EMBO J. 6, 363-368.
30. Cato, A. C. B., Micsicek, R., Schütz, G., Arnemann, J. & Beato, M. (1986) The hormone regulatory element of mouse mammary tumor virus mediates progesterone induction, EMBO J. 5, 2237-2240.
31. Brinkmann, A. O., Faber, P. W., Van Rooij, H. C. J., Kuiper, G. G. M., Ris, C., Klaassen, P., Van Der Korput, J. A. G. M., Voorhorst, M. M., Van Laar, J. H., Mulder, E. & Trapman, J. (1989) The human androgen receptor: domain structure, genomic organization and regulation of expression, J. Steroid Biochem. 34, 307-310.
32. Guiochon-Mantel, A., Loosfelt, H., Ragot, T., Bailly, A., Atger, M., Misrahi, M., Perricaudet, M. & Milgrom, E. (1988) Receptors bound to antiprogestin form abortive complexes with hormone responsive elements, Nature 336, 695-698.
33. Kumar, V., Green, S., Stack, G., Berry, M., Jin, J.-R. & Chambon, P. (1987) Functional domains of the human estrogen receptor, Cell 51, 941-951.
34. Neumann, J. R., Morency, C. A. & Russian, K. O. (1987) A novel rapid assay for chloramphenicol acetyltransferase gene expression, Biotechniques 5, 444-447.
35. Bubulya, A., Wise, S. L., Shen, X. Q., Burmeister, L. A. & Shemshedini, L. (1996) c-jun can mediate androgen receptor-induced transactivation, J. Biol. Chem. 271, 24 583-24 589.
36. Georget, V., Lobaccaro, J. M., Terouanne, B., Mangeat, P., Nicolas, J.-C. & Sultan, C. (1997) Trafficking of the androgen receptor in living cells with fused green fluorescent protein-androgen receptor, Mol. Cell. Endocrinol. 129, 17-26.
37. Lim-Tio, S. S. & Fuller, P. J. (1998) Intracellular signaling pathways confer specificity of transactivation by mineralocorticoid and glucocorticoid receptors, Endocrinology 139, 1653-1661.
38. Zhou, Z. X., Kemppainen, J. A. & Wilson, E. M. (1995) Identification of three proline directed phosphorylation sites in the human androgen receptor, Mol. Endocrinol. 9, 605-615.
39. Smith, D. F. & Toft, D. O. (1993) Steroid receptors and their associated proteins, Mol. Endocrinol. 7, 3-11.
40. Adler, V., Franklin, C. C. & Kraft, A. S. (1992) Phorbol esters stimulate the phosphorylation of c-jun but not v-jun: regulation by the N-terminal S domain, Proc. Natl Acad. Sci. USA 89, 5341-5345.
41. Wolf, D., Schulz, P. & Fittler, F. (1992) Transcriptional regulation of prostate kallikrein-like genes by androgen, Mol. Endocrinol. 6, 753-762.
42. Murtha, P., Tindall, D. J. & Young, C. Y. F. (1993) Androgen induction of a human prostate-specific kallikrein, hKLK2: characterization of an androgen response element in the 5′ promoter region of the gene, Biochemistry 32, 6459-6464.
43. Roy, R., Gosselin, P. & Guerin, S. L. (1991) A short protocol for micropurification of nuclear proteins from whole animal tissues, Biotechniques 11, 770-777.
44. Miksicek, R., Borgmeyer, U. & Nowock, J. (1987) Interaction of the TGGCA-binding protein with upstream sequences is required for efficient transcription of mouse mammary tumor virus, EMBO J. 6, 1355-1360.
45. Simon, A. M., Brochard, D., Morel, L., Veyssière, G. & Jean, C. (1996) The androgen-dependent mouse seminal vesicle secretory protein of 99 amino acids (MSVSP99): regulation of the mRNA and preliminary characterization of the promoter, J. Steroid Biochem. Molec. Biol. 61, 87-95.
46. Gelman, L., Staels, B. & Auwerx, J. (1997) Rôle dos co-facteurs transcriptionnels dans la transduction des signaux hormonaux par les récepteurs nucléaires, Médecine Sciences 13, 961-970.
47. Trapman, J. & Brinkmann, A. O. (1996) The androgen receptor in prostate cancer, Pathol. Res. Pract. 192, 752-760.
48. Curtis, S. W., Washburn, T., Sevall, C., Di Augustine, R., Lindzey, J., Couse, J. F. & Korach, K. S. (1996) Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor, Proc. Natl. Acad. Sci. USA 93, 12 626-12 630.
49. Henderson, B. E., Ross, R. K. & Pike, C. M. (1991) Toward the primary prevention of cancer, Science 254, 1131-1138.