Characterization of a mobile stat6 activation motif in the human IL-4 receptor

Journal of Immunology

Volumn 161, Issue 4, 1998, Pages 1811-1821

  Ryan, John J ^a,b   McReynolds, Lisa J ^a   Huang, Hua ^a   Nelms, Keats ^a   Paul, William E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BASOPHIL; GENE ACTIVATION; GENE CONTROL; GENE LOCATION; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; AMINO ACIDS; ANIMALS; BASE SEQUENCE; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-4; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PHOSPHOTYROSINE; PROTEIN BINDING; RECEPTORS, IGE; RECEPTORS, INTERLEUKIN-4; SEQUENCE DELETION; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TYROSINE;

EID: 0032529410     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Paul, W. E., and R. A. Seder. 1994. Lymphocyte responses and cytokines. Cell 76:241.
2. Ohara, J., and W. E. Paul. 1987. Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature 325:537.
3. Lowenthal, J. W., B. E. Castle, J. Christiansen, J. Schreurs, D. Rennick, N. Arai, P. Hoy, Y. Takebe, and M. Howard. 1988. Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells. J. Immunol. 140:456.
4. Park, L. S., D. Friend, H. M. Sassenfeld, and D. L. Urdal. 1987. Characterization of the human B cell stimulatory factor 1 receptor. J. Exp. Med. 166: 476.
5. Russell, S. M., A. D. Keegan, N. Harada, Y. Nakamura, M. Noguchi, P. Leland, M. C. Friedmann, A. Miyajima, R. K. Puri, W. E. Paul, and W. J. Leonard. 1993. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science 262:1880.
6. Miyazaki, T., A. Kawahara, H. Fujii, Y. Nakagawa, Y. Minami, Z. J. Liu, I. Oishi, O. Silvennoinen, B. A. Witthuhn, J. N. Ihle, and T. Taniguchi. 1994. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 266:1045.
7. Keegan, A. D., J. J. Ryan, and W. E. Paul. 1996. IL-4 regulates growth and differentiation by distinct mechanisms. Immunologist 4:194.
8. + T cell IL-4 production is revealed in interleukin-4 receptor deficient mice. Proc. Natl. Acad. Sci. USA 94:10838.
9. Nosaka, T., D. J. van, R. A. Tripp, W. E. Thierfelder, B. A. Witthuhn, A. P. McMickle, P. C. Doherty, G. C. Grosveld, and J. N. Ihle. 1995. Defective lymphoid development in mice lacking Jak3. Science 270:800.
10. Park, S. Y., K. Saijo, T. Takahashi, M. Osawa, H. Arase, N. Hirayama, K. Miyake, H. Nakauchi, T. Shirasawa, and T. Saito. 1995. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity 3:771.
11. Thomis, D. C., C. B. Gurniak, E. Tivol, A. H. Sharpe, and L. J. Berg. 1995. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270:794.
12. Wang, H. Y., J. Zamorano, J. L. Yoerkie, W. E. Paul, and A. D. Keegan. 1997. The IL-4-induced tyrosine phosphorylation of the insulin receptor substrate is dependent on JAK1 expression in human fibrosarcoma cells. J. Immunol. 158: 1037.
13. Chen, X. H., B. K. Patel, L. M. Wang, M. Frankel, N. Ellmore, R. A. Flavell, W. J. LaRochelle, and J. H. Pierce. 1997. Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules. J. Biol. Chem. 272:6556.
14. Ryan, J. J., L. J. McReynolds, A. Keegan, L. H. Wang, E. Garfein, P. Rothman, K. Nelms, and W. E. Paul. 1996. Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor. Immunity 4:123.
15. Keegan, A. D., K. Nelms, M. White, L. M. Wang, J. H. Pierce, and W. E. Paul. 1994. An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth. Cell 76:811.
16. Wang, H. Y., W. E. Paul, and A. D. Keegan. 1996. IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor alpha chain. Immunity 4:113.
17. Conrad, D. H., T. J. Waldschmidt, W. T. Lee, M. Rao, A. D. Keegan, R. J. Noelle, R. G. Lynch, and M. R. Kehry. 1987. Effect of B cell stimulatory factor-1 (interleukin 4) on Fc epsilon and Fc gamma receptor expression on murine B lymphocytes and B cell lines. J. Immunol. 139:2290.
18. Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4:313.
19. Shimoda, K., D. J. van, M. Y. Sangster, S. R. Sarawar, R. T. Carson, R. A. Tripp, C. Chu, F. W. Quelle, T. Nosaka, D. A. Vignali, P. C. Doherty, G. Grosveld, W. E. Paul, and J. N. Ihle. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380:630.
20. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of Stat6 in IL-4 signalling. Nature 380:627.
21. Hershey, G., M. Friedrich, L. Esswein, M. Thomas, and T. Chatila. 1997. The association of atopy with a gain-of-function mutation in the α subunit of the interleukin-4 receptor. New Engl. J. Med. 337:1720.
22. Huang, H., J. Hu-Li, H.-J. Chen, S. Z. Ben-Sasson, and W. E. Paul. 1997. IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent. J. Immunol. 159:3731.
23. Golemis, E. A., and R. Brent. 1992. Fused protein domains inhibit DNA binding by LexA. Mol. Cell. Biol. 12:3006.
24. Gyuris, J., E. Golemis, H. Chertkov, and R. Brent. 1993. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell 75:791.
25. Zervos, A. S., E. Gyuris, and R. Brent. 1993. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell 72:223.
26. O'Neill, T. J., A. Craparo, and T. A. Gustafson. 1994. Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system. Mol. Cell. Biol. 14:6433.
27. Hou, J., U. Schindler, W. J. Henzel, T. C. Ho, M. Brasseur, and S. L. McKnight. 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265:1701.
28. Kavanaugh, W. M., C. Turck, and L. T. Williams. 1995. PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine. Science 268:1177.
29. Snapper, C. M., F. D. Finkelman, and W. E. Paul. 1988. Differential regulation of IgG1 and IgE synthesis by interleukin 4. J. Exp. Med. 167:183.
30. Gustafson, T. A., W. He, A. Craparo, C. D. Schaub, and T. J. O'Neill. 1995. Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell. Biol. 15:2500.
31. He, W., A. Craparo, Y. Zhu, T. J. O'Neill, L. M. Wang, J. H. Pierce, and T. A. Gustafson. 1996. Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors: evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2. J. Biol. Chem. 271: 11641.
32. Wang, L. M., A. D. Keegan, W. E. Paul, M. A. Heidaran, J. S. Gutkind, and J. H. Pierce. 1992. IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells. EMBO J. 11:4899.
33. Wang, L. M., M. J. Myers, X. J. Sun, S. A. Aaronson, M. White, and J. H. Pierce. 1993. IRS-1: essential for insulin-and IL-4-stimulated mitogenesis in hematopoietic cells. Science 261:1591.
34. Stahl, N., T. J. Farruggella, T. G. Boulton, Z. Zhong, J. J. Darnell, and G. D. Yancopoulos. 1995. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267:1349.
35. Richter, G., G. Hein, T. Blakenstein, and T. Diamantstein. 1995 The rat interleukin 4 receptor: coevolution of ligand and receptor. Cytokine 7:237.
36. Hatada, M., X. Lu, E. K. Laird, J. Green, J. P. Morgenstern, M. Lou, C. S. Marr, T. B. Phillips, M. K. Ram, K. Theriault, M. Zoller, and J. Karas. 1995. Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature 377:32.
37. Gerhartz, C., B. Hessel, J. Sasse, U. Hemmann, C. Landgraf, J. Schneider-Mergener, F. Horn, P. Heinrich, and L. Graeve. 1996. Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin-6 signal transducer gp130. J. Biol. Chem. 271:12991.
38. May, P.,C. Gerhartz, B. Heesel, T. Welte, W. Doppler, L. Graeve, F. Horn, and P. Heinrich. 1996. Comparative study on the phosphotyrosine motifs of different cytokine receptors involved in STATS activation. FEBS Lett. 394:221.