Transcription of Epstein-Barr virus latent cycle genes in oral hairy leukoplakia

Virology

Volumn 248, Issue 1, 1998, Pages 53-65

  Webster Cyriaque, J ^a   Raab Traub, N ^a  

^a UNIVERSITY OF NORTH CAROLINA HOSPITALS   (United States)

Author keywords

AIDS; EBV; Epithelial infection; Gene expression; Hairy leukoplakia; Oral lesion

Indexed keywords

ARTICLE; CELL LINE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LATENT VIRUS INFECTION; LEUKOPLAKIA; LYMPHOCYTE; MEMBRANE BINDING; MOUTH LESION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPERINFECTION; VIRUS CELL INTERACTION; VIRUS GENE; VIRUS REPLICATION;

EID: 0032529344     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9268     Document Type: Article

References (73)

1. Billaud M., Busson P., Huang D., Mueller-Lantzch N., Rousselet G., Pavlish O., Wakasugi H., Seigneurin J. M., Tursz T., Lenoir G. M. Epstein-Barr virus (EBV)-containing nasopharyngeal carcinoma cells express the B-cell activation antigen blast2/CD23 and low levels of the EBV receptor CR2. J. Virol. 63:1989;4121-4128.
2. Birkenbach M., Tong X., Bradbury L. E., Tedder T. F., Kieff E. Characterization of an Epstein-Barr virus receptor on human epithelial cells. J. Exp. Med. 176:1992;1405-1414.
3. Blazar B., Patarroyo M., Klein E., Klein G. Increased sensitivity of human lymphoid lines to natural killer cells after induction of the Epstein-Barr viral cycle by superinfection or sodium butyrate. J. Exp. Med. 151:1980;614-627.
4. Bodescot M., Perricaudet M., Farrell P. J. A promoter for the highly spliced EBNA family of RNAs of Epstein-Barr virus. J. Virol. 61:1987;3424-3430.
5. Brooks L. A., Lear A. L., Young L. S., Rickinson A. B. Transcripts from the Epstein-Barr virus BamHI A fragment are detectable in all three forms of virus latency. J. Virol. 67:1993;3182-3190.
6. Burrows J. M., Khanna R., Sculley T. B., Alpers M. P., Moss D. J., Burrows S. R. Identification of a naturally occurring recombinant Epstein-Barr virus isolate from New Guinea that encodes both type1 and type2 nuclear antigen sequences. J. Virol. 70:1996;4829-4833.
7. Chen F., Zou J. Z., di Renzo L., Winberg G., Hu L. F., Klein E., Klein G., Ernberg I. A subpopulation of normal B cells latently infected with Epstein-Barr virus resembles Burkitt lymphoma cells in expressing EBNA-1 but not EBNA-2 or LMP1. J. Virol. 69:1995;3752-3758.
8. Cooper N. R., Bradt B. M., Rhim J. S., Nemerow G. R. CR2 complement receptor. J. Invest. Dermatol. 94:1990;112S-117S.
9. Cordier M., Calender A., Billaud M., Zimber U., Rousselet G., Pavlish O., Banchereau J., Tursz T., Bornkamm G., Lenoir G. M. Stable transfection of Epstein-Barr virus (EBV) nuclear antigen 2 in lymphoma cells containing the EBV P3HR1 genome induces expression of B-cell activation molecules CD21 and CD23. J. Virol. 64:1990;1002-1013.
10. Deacon E. M., Pallesen G., Niedobitek G., Crocker J., Brooks L., Rickinson A. B., Young L. S. Epstein-Barr virus and Hodgkin's disease: Transcriptional analysis of virus latency in the malignant cells. J. Exp. Med. 177:1993;339-349.
11. Evans T. J., Farrell P. J., Swaminathan S. Molecular genetic analysis of Epstein-Barr virus Cp promoter function. J. Virol. 70:1996;1695-1705.
12. Fries K. L., Miller W. E., Raab-Traub N. Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene. J. Virol. 70:1996;8653-8659.
13. Gilligan K. J., Rajadurai P., Lin J. C., Busson P., Abdel-Hamid M., Prasad U., Tursz T., Raab-Traub N. Expression of the Epstein-Barr virus BamHI A fragment in nasopharyngeal carcinoma: Evidence for a viral protein expressed in vivo. J. Virol. 65:1991;6252-6259.
14. Gilligan K., Rajadurai P., Resnick L., Raab-Traub N. Epstein-Barr virus small nuclear RNAs are not expressed in permissively infected cells in AIDS-associated leukoplakia. Proc. Natl. Acad. Sci. USA. 87:1990;8790-8794.
15. Green T., Greenspan J., Greenspan D., DeSouza Y. Oral lesions mimicking hairy leukoplakia: A diagnostic dilemma. Oral Surg. Oral Med. Oral Pathol. 67:1989;422-426.
16. Greenspan J. S., Greenspan D., Lennette E. T., Abrams D. I., Conant M. A., Petersen V., Freese U. K. Replication of Epstein-Barr virus within the epithelial cells of oral "hairy" leukoplakia, an AIDS-associated lesion. N. Engl. J. Med. 313:1985;1564-1571.
17. Hamilton-Dutoit S. J., Rea D., Raphael M., Sandvej K., Delecluse H. J., Gisselbrecht C., Marelle L., van Krieken H. J., Pallesen G. Epstein-Barr virus-latent gene expression and tumor cell phenotype in acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma. Correlation of lymphoma phenotype with three distinct patterns of viral latency. Am. J. Pathol. 143:1993;1072-1085.
18. Harada S., Kieff E. Epstein-Barr virus nuclear protein LP stimulates EBNA-2 acidic domain-mediated transcriptional activation. J. Virol. 71:1997;6611-6618.
19. Heller M., van Santen V., Kieff E. Simple repeat sequence in Epstein-Barr virus DNA is transcribed in latent and productive infections. J. Virol. 44:1982;311-320.
20. Hitt M. M., Allday M. J., Hara T., Karran L., Jones M. D., Busson P., Tursz T., Ernberg I., Griffin B. E. EBV gene expression in an NPC-related tumour. EMBO Journal. 8:1989;2639-2651.
21. Hummel M., Kieff E. Epstein-Barr virus RNA. VIII. Viral RNA in permissively infected B95-8 cells. J. Virol. 43:1982;262-272.
22. Kaye K. M., Izumi K. M., Kieff E. Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proc. Natl. Acad. Sci. USA. 90:1993;9150-9154.
23. Kenney S., Kamine J., Holley-Guthrie E., Lin J. C., Mar E. C., Pagano J. The Epstein-Barr virus (EBV) BZLF1 immediate-early gene product differentially affects latent versus productive EBV promoters. J. Virol. 63:1989;1729-1736.
24. Kerr B. M., Lear A. L., Rowe M., Croom-Carter D., Young L. S., Rookes S. M., Gallimore P. H., Rickinson A. B. Three transcriptionally distinct forms of Epstein-Barr virus latency in somatic cell hybrids: Cell phenotype dependence of virus promoter usage. Virology. 187:1992;189-201.
25. Kieff, E. 1996, Epstein-Barr virus and its replication, In, Fields Virology, 2, 2343, 2396, Lippincott-Raven Publishers, Philadelphia.
26. Larcher C., Fend F., Mitterer M., Prang N., Schwarzmann F., Huemer H. P. Role of Epstein-Barr virus and soluble CD21 in persistent polyclonal B-cell lymphocytosis. Br. J. Haematol. 90:1995;532-540.
27. Lau R., Middeldorp J., Farrell P. J. Epstein-Barr virus gene expression in oral hairy leukoplakia. Virology. 195:1993;463-474.
28. Lemon, S. M. Hutt, L. M. Shaw, J. E. Li, J. L. Pagano, J. S. 1978, Replication of Epstein-Barr Virus DNA in Epithelial Cells In Vivo, 739, 744, IARC Scientific Publications.
29. Miller C. L., Lee J. H., Kieff E., Longnecker R. An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking. Proc. Natl. Acad. Sci. USA. 91:1994;772-776.
30. Miller W. E., Earp H. S., Raab-Traub N. The Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor. J. Virol. 69:1995;4390-4398.
31. Miller W. E., Mosialos G., Kieff E., Raab-Traub N. Epstein-Barr virus LMP1 induction of the epidermal growth factor receptor is mediated through a TRAF signaling pathway distinct from NF-kappaB activation. J. Virol. 71:1997;586-594.
32. Murray P. G., Niedobitek G., Kremmer E., Grasser F., Reynolds G. M., Cruchley A., Williams D. M., Muller-Lantzsch N., Young L. S. In situ detection of the Epstein-Barr virus-encoded nuclear antigen 1 in oral hairy leukoplakia and virus-associated carcinomas. J. Pathol. 178:1996;44-47.
33. Niedobitek G., Young L. S., Lau R., Brooks L., Greenspan D., Greenspan J. S., Rickinson A. B. Epstein-Barr virus infection in oral hairy leukoplakia: Virus replication in the absence of a detectable latent phase. J. Gen. Virol. 72:1991;3035-3046.
34. Nitsche F., Bell A., Rickinson A. Epstein-Barr virus leader protein enhances EBNA-2-mediated transactivation of latent membrane protein 1 expression: A role for the W1W2 repeat domain. J. Virol. 71:1997;6619-6628.
35. Nonkwelo C., Skinner J., Bell A., Rickinson A., Sample J. Transcription start sites downstream of the Epstein-Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 protein. J. Virol. 70:1996;623-627.
36. Puglielli M. T., Desai N., Speck S. H. Regulation of EBNA gene transcription in lymphoblastoid cell lines: Characterization of sequences downstream of BCR2 (Cp). J. Virol. 71:1997;120-128.
37. Puglielli M. T., Woisetschlaeger M., Speck S. H. oriP is essential for Ebna gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines. J. Virol. 70:1996;5758-5768.
38. Qu L., Rowe D. T. Epstein-Barr virus latent gene expression in uncultured peripheral blood lymphocytes. J. Virol. 66:1992;3715-3724.
39. Raab-Traub N. Epstein-Barr virus infection in nasopharyngeal carcinoma. Infect. Agents Dis. 1:1992;173-184.
40. Raab-Traub N., Flynn K. The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell. 47:1986;883-889.
41. Raab-Traub N., Hood R., Yang C. S., Henry B. D., Pagano J. S. Epstein-Barr virus transcription in nasopharyngeal carcinoma. J. Virol. 48:1983;580-590.
42. Rabson M., Gradoville L., Heston L., Miller G. Non-immortalizing P3J-HR-1 Epstein-Barr virus: A deletion mutant of its transforming parent, Jijoye. J. Virol. 44:1982;834-844.
43. Rickinson, A. B. Jarvis, J. E. Crawford, D. H. Epstein, M. A. 1975, Observations on the Nature of Epstein-Barr Virus Infection of Peripheral Lymphoid Cells in Infectious Mononucleosis, 169, 177, IARC Scientific Publications.
44. Rogers R. P., Woisetschlaeger M., Speck S. H. Alternative splicing dictates translational start in Epstein-Barr virus transcripts. EMBO J. 9:1990;2273-2277.
45. Rowe M., Rowe D. T., Gregory C. D., Young L. S., Farrell P. J., Rupani H., Rickinson A. B. Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells. EMBO J. 6:1987;2743-2751.
46. Sadler R. H., Raab-Traub N. Structural analyses of the Epstein-Barr virus BamHI A transcripts. J. Virol. 69:1995;1132-1141.
47. Sample J., Brooks L., Sample C., Young L., Rowe M., Gregory C., Rickinson A., Kieff E. Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen 1 transcriptional initiation site. Proc. Natl. Acad. Sci. USA. 88:1991;6343-6347.
48. Sample J., Hummel M., Braun D., Birkenbach M., Kieff E. Nucleotide sequences of mRNAs encoding Epstein-Barr virus nuclear proteins: A probable transcriptional initiation site. Proc. Natl. Acad. Sci. USA. 83:1986;5096-5100.
49. Sato H., Takimoto T., Tanaka S., Tanaka J., Raab-Traub N. Concatameric replication of Epstein-Barr virus: Structure of the termini in virus-producer and newly transformed cell lines. J. Virol. 64:1990;5295-5300.
50. Schaefer B. C., Strominger J. L., Speck S. H. The Epstein-Barr virus BamHI F promoter is an early lytic promoter: Lack of correlation with EBNA 1 gene transcription in group 1 Burkitt's lymphoma cell lines. J. Virol. 69:1995;5039-5047.
51. Sinclair A. J., Brimmell M., Farrell P. J. Reciprocal antagonism of steroid hormones and BZLF1 in switch between Epstein-Barr virus latent and productive cycle gene expression. J. Virol. 66:1992;70-77.
52. Sixbey J. W., Nedrud J. G., Raab-Traub N., Hanes R. A., Pagano J. S. Epstein-Barr virus replication in oropharyngeal epithelial cells. N. Engl. J. Med. 310:1984;1225-1230.
53. Speck S. H., Pfitzner A., Strominger J. L. An Epstein-Barr virus transcript from a latently infected, growth-transformed B-cell line encodes a highly repetitive polypeptide. Proc. Natl. Acad. Sci. USA. 83:1986;9298-9302.
54. Sugano N., Chen W., Roberts M. L., Cooper N. R. Epstein-Barr virus binding to CD21 activates the initial viral promoter via NF-kappaB induction. J. Exp. Med. 186:1997;731-777.
55. Sung N. S., Kenney S., Gutsch D., Pagano J. S. EBNA-2 transactivates a lymphoid-specific enhancer in the BamHI C promoter of Epstein-Barr virus. J. Virol. 65:1991;2164-2169.
56. Takada K. Cross-linking of cell surface immunoglobulins induces Epstein-Barr virus in Burkitt lymphoma lines. Int. J. Cancer. 33:1984;27-32.
57. Taylor K. A., Wetzel S., Lyles D. S., Pollok B. A. Dual EBNA1 promoter usage by Epstein-Barr virus in human B-cell lines expressing unique intermediate cellular phenotypes. J. Virol. 68:1994;6421-6431.
58. Thomas J. A., Felix D. H., Wray D., Southam J. C., Cubie H. A., Crawford D. H. Epstein-Barr virus gene expression and epithelial cell differentiation in oral hairy leukoplakia. Am. J. Pathol. 139:1991;1369-1380.
59. Thomas J. A., Hotchin N. A., Allday M. J., Amlot P., Rose M., Yacoub M., Crawford D. H. Immunohistology of Epstein-Barr virus-associated antigens in B cell disorders from immunocompromised individuals. Transplantation. 49:1990;944-953.
60. Tierney R. J., Steven N., Young L. S., Rickinson A. B. Epstein-Barr virus latency in blood mononuclear cells: Analysis of viral gene transcription during primary infection and in the carrier state. J. Virol. 68:1994;7374-7385.
61. Walling D. M., Edminston S. N., Sixbey J. W., Abdel-Hamid M., Resnick L., Raab-Traub N. Coinfection with multiple strains of the Epstein-Barr virus in human immunodeficiency virus-associated hairy leukoplakia. Proc. Natl. Acad. Sci. USA. 89:1992;6560-6564.
62. Walling D. M., Perkins A. G., Webster-Cyriaque J., Resnick L., Raab-Traub N. The Epstein-Barr virus EBNA-2 gene in oral hairy leukoplakia: Strain variation, genetic recombination, and transcriptional expression. J. Virol. 68:1994;7918-7926.
63. Walling D. M., Raab-Traub N. Epstein-Barr virus intrastrain recombination in oral hairy leukoplakia. J. Virol. 68:1994;7909-7917.
64. Wang F., Gregory C. D., Rowe M., Rickinson A. B., Wang D., Birkenbach M., Kikutani H., Kishimoto T., Kieff E. Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23. Proc. Natl. Acad. Sci. USA. 84:1987a;3452-3456.
65. Wang F., Gregory C., Sample C., Rowe M., Liebowitz D., Murray R., Rickinson A., Kieff E. Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23. J. Virol. 64:1990;2309-2318.
66. Wang F., Petti L., Braun D., Seung S., Kieff E. A bicistronic Epstein-Barr virus mRNA encodes two nuclear proteins in latently infected, growth-transformed lymphocytes. J. Virol. 61:1987b;945-954.
67. Weigel R., Fischer D. K., Heston L., Miller G. Constitutive expression of Epstein-Barr virus-encoded RNAs and nuclear antigen during latency and after induction of Epstein-Barr virus replication. J. Virol. 53:1985;254-259.
68. Wilson J. B., Weinberg W., Johnson R., Yuspa S., Levine A. J. Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6. Cell. 61:1990;1315-1327.
69. Woisetschlaeger M., Jin X. W., Yandava C. N., Furmanski L. A., Strominger J. L., Speck S. H. Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection. Proc. Natl. Acad. Sci. USA. 88:1991;3942-3946.
70. Woisetschlaeger M., Strominger J. L., Speck S. H. Mutually exclusive use of viral promoters in Epstein-Barr virus latently infected lymphocytes. Proc. Natl. Acad. Sci. USA. 86:1989;6498-6502.
71. Woisetschlaeger M., Yandava C. N., Furmanski L. A., Strominger J. L., Speck S. H. Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes. Proc. Natl. Acad. Sci. USA. 87:1990;1725-1729.
72. Yao Q. Y., Tierney R. J., Croom-Carter D., Cooper G. M., Ellis C. J., Rowe M., Rickinson A. B. Isolation of intertypic recombinants of Epstein-Barr virus from T-cell-immunocompromised individuals. J. Virol. 70:1996;4895-4903.
73. Yoo L., Mooney M., Pugnelli M., Speck S. B-Cell lines immortalized with an Epstein-Barr virus mutant lacking the Cp EBNA2 enhancer are biased toward utilization of the oriP-proximal EBNA gene promoter Wp1. J. Virol. 71:1997;9134-9142.