BCR/ABL-negative progenitors are enriched in the adherent fraction of CD34+ cells circulating in the blood of chronic phase chronic myeloid leukemia patients

Leukemia

Volumn 11, Issue 9, 1997, Pages 1486-1492

  Grand, F H ^a   Marley, S B ^a   Chase, A ^a   Titley, I ^b   Healy, L ^b   Spencer, A ^a   Reiter, A ^a   Goldman, J M ^a   Gordon, M Y ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

BCR ABL; CD34; CML; FISH

Indexed keywords

BCR ABL PROTEIN; CD33 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; HLA DR ANTIGEN; PLASTIC;

ADHERENT CELL; ADULT; ANTIGEN EXPRESSION; ARTICLE; CELL ADHESION; CELL FRACTIONATION; CELL SELECTION; CELL SUBPOPULATION; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MALE; ONCOGENE; PHENOTYPE; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE CULTURE;

EID: 0030832174     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400748     Document Type: Article

References (11)

1. Rowley JS. The Philadelphia chromosome translocation: a paradigm for understanding leukemia. Cancer 1990; 65: 2178-2183.
2. Bartram CR, deKlein A, Hagemeier A, van Agthoven T, Guerts van Kessel A, Bootsma D, Grosveld G, Ferguson-Smith MA, Davies T, Stone M. Translocation of the c-abl oncogene adjacent to a translocation breakpoint in chronic myelocytic leukemia. Nature 1983; 306: 277-280.
3. Ben-Neriah Y, Daley GQ, Mes-Masson A-M, Witte ON, Baltimore D. The chronic myelogenous leukemia-specific p210 is the product of the bcr-abl hybrid gene. Science 1986; 233: 212-214.
4. Fialkow PJ, Jacobson RJ, Papayannopoulou Th. Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte macrophage. Am J Med 1977; 63: 125-130.
5. Gordon MY, Dowding CR, Riley GP, Goldman JM, Greaves MF. Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia. Nature 1987; 328: 342-344.
6. Verfaillie CM, McCarthy JB, McGlave PB. Mechanisms underlying the abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to basement membrane components laminin and collagen type IV. J Clin Invest 1992; 90: 1232-1241.
7. Talpaz M, Kantarjian HM, Kurzrock R, Trujillo JM, Gutterman JU. Interferon-alpha produces sustained cytogenetic responses in chronic myeloid leukemia. Ann Intern Med 1991; 114: 532-538.
8. Meloni G, DeFabritis P, Alimena G, Malagnino F, Montefusco E, Sandrelli A, Pinto R, Vignetti M, LoCoco F, Mandelli F. Autologous bone marrow or peripheral blood stem cell transplantation for patients with chronic myelogenous leukemia in chronic phase. Bone Marrow Transplant 1989; 4 (Suppl. 4): 92-96.
9. Carella AM, Podesta M, Frassoni F, Raffo MR, Pollicardo N, Pungolino E, Vimercati R, Sessarego M, Parodi C, Rabitti C, Ferrero R, Benvenuto F, Figari O, Carlier P, Levcasic G, Valbonesi M, Vitale V, Perluigi D, Nati S, Guerracio A, Rosso C, Saglio G. Collection of 'normal' blood repopulating cells during early hemopoietic recovery after intensive conventional chemotherapy in chronic myelogenous leukemia. Bone Marrow Transplant 1993; 12: 267-271.
10. Brito-Babapulle F, Bowcock SJ, Marcus RE, Apperley J, Th'ng KH, Dowding C, Rasool F, Guo A-P, Catovsky D, Galton DAG, McCarthy D, Goldman JM. Autografting for patients with chronic myeloid leukaemia in chronic phase: peripheral blood stem cells may have a finite capacity for maintaining haemopoiesis. Br J Haematol 1989; 73: 76-81.
11. Udomsakdi C, Eaves CJ, Swolin B, Reid DS, Barnett MJ, Eaves AC. Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level. Proc Natl Acad Sci USA 1992; 89: 6192-6196.