Role of interferon-γ in the pathogenesis of LCMV-induced meningitis: Unimpaired leucocyte recruitment, but deficient macrophage activation in interferon-γ knock-out mice

Journal of Neuroimmunology

Volumn 86, Issue 2, 1998, Pages 202-212

  Nansen, A ^a   Christensen, J Pravsgaard ^a   Ropke C ^a   Marker, O ^a   Scheynius, A ^b   Thomsen, A Randrup ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Division of Clinical Immunology   (Sweden)

Author keywords

CD8+ T cells; Cell adhesion molecules; Inflammation; Interferon ; NO; Virus induced meningitis

Indexed keywords

GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ARTICLE; CELLULAR IMMUNITY; INFECTION CONTROL; KNOCKOUT MOUSE; LEUKOCYTE MIGRATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; VIRUS MENINGITIS;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL ADHESION MOLECULES; EDEMA; ENDOTHELIUM; FEMALE; FLOW CYTOMETRY; INTERFERON TYPE II; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MACROPHAGE-1 ANTIGEN; MACROPHAGES; MALE; MENINGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; TUMOR NECROSIS FACTOR-ALPHA; VIRULENCE;

EID: 0032526197     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(98)00055-1     Document Type: Article

References (46)

1. Allan J.E., Dixon J.E., Doherty P.C. Nature of the inflammatory process in the central nervous system of mice infected with lymphocytic choriomeningitis virus. Curr. Top. Microbiol. Immunol. 134:1987;131-143.
2. Andersson E.C., Christensen J.P., Marker O., Thomsen A.R. Changes in cell adhesion molecule expression on T cells associated with systemic virus infection. J. Immunol. 152:1994;1237-1245.
3. + T cells. Scand. J. Immunol. 42:1995;110-118.
4. Asensio V.C., Campbell I.L. Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis. J. Virol. 71:1997;7832-7840.
5. Campbell I.L., Hobbs M.V., Kemper P., Oldstone M.B. Cerebral expression of multiple cytokine genes in mice with lymphocytic choriomeningitis. J. Immunol. 152:1994;716-723.
6. Campbell I.L., Samimi A., Chiang C.S. Expression of the inducible nitric oxide synthase. Correlation with neuropathology and clinical features in mice with lymphocytic choriomeningitis. J. Immunol. 153:1994;3622-3629.
7. Ceredig R., Allan J.E., Tabi Z., Lynch F., Doherty P.C. Phenotypic analysis of the inflammatory exudate in murine lymphocytic choriomeningitis. J. Exp. Med. 165:1987;1539-1551.
8. + T cells in cell-mediated immunity to LCMV: studies in MHC class I and class II deficient mice. Scand. J. Immunol. 40:1994;373-382.
9. + T cells to sites of infection. J. Immunol. 154:1995;5293-5301.
10. 2-integrin (CD18)- and ICAM-1 (CD54)-deficient mice. J. Virol. 70:1996;8997-9002.
11. 4-integrin expression. Int. Immunol. 8:1996;707-715.
12. + T cells with a type 1 cytokine profile. Int. Immunol. 8:1996;1453-1461.
13. Dalton D.K., Pitts-Meek S., Keshav S., Figari I.S., Bradley A., Stewart T.A. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science. 259:1993;1739-1742.
14. Ding A.H., Nathan C.F., Stuehr D.J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141:1988;2407-2412.
15. + T cells. Immunol. Today. 11:1990;55-59.
16. Doherty P.C., Allan W., Eichelberger M., Carding S.R. Roles of αβ and γδ T cell subsets in viral immunity. Ann. Rev. Immunol. 10:1992;123-151.
17. Dustin M.L., Rothlein R., Bhan A.K., Dinarello C.A., Springer T.A. Induction by IL-1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 137:1986;245-254.
18. Frei K., Leist T.P., Meager A., Gallo P., Leppert D., Zinkernagel R.M. Production of B cell stimulatory factor-2 and interferon-γ in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients. J. Exp. Med. 168:1988;449-453.
19. Huang S., Hendriks W., Althage A., Hemmi S., Bluethmann H., Kamijo R.V.J., Zinkernagel R.M., Aguet M. Immune response in mice that lack the interferon-γ receptor. Science. 259:1993;1742-1745.
20. Issekutz T.B. Effects of six different cytokines on lymphocyte adherence to microvascular endothelium and in vivo lymphocyte migration in the rat. J. Immunol. 144:1990;2140-2146.
21. Issekutz T.B., Stoltz J.M., van der Meide P. The recruitment of lymphocytes into the skin by T cell lymphokines: the role of interferon-γ Clin. Exp. Immunol. 73:1988;70-75.
22. Jones L.S., Rizzo L.V., Agarwal R.K., Tarrant T.K., Chan C.C., Wiggert B.C. IFN-γ-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response. J. Immunol. 158:1997;5997-6005.
23. Kundig T.M., Althage A., Hengartner H., Zinkernagel R.M. Skin test to assess virus-specific cytotoxic T cell activity. Proc. Natl. Acad. Sci. U.S.A. 89:1992;7757-7761.
24. Lafaille J.J., Keere F.V., Hsu A.L., Baron J.L., Haas W., Raine C.S., Tonegawa S. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J. Exp. Med. 186:1997;307-312.
25. Leist T.P., Frei K., Kam-Hansen S., Zinkernagel R.M., Fontana A. Tumor necrosis factor α in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and in patients. J. Exp. Med. 167:1988;1743-1748.
26. Leist T.P., Heuchel R., Zinkernagel R.M. Increased bactericidal macrophage activity induced by immunological stimuli is dependent on interferon (IFN)-γ. Interference of anti-IFN-γ but not anti-IFN-α/β with modulation of macrophage activity caused by lymphocytic choriomeningitis virus infection or systemic graft-vs.-host reactions. Eur. J. Immunol. 18:1988;1295-1298.
27. Leist T.P., Eppler M., Zinkernagel R.M. Enhanced virus replication and inhibition of lymphocytic choriomeningitis virus disease in anti-interferon-γ-treated mice. J. Virol. 63:1989;2813-2819.
28. Li L., Sad S., Kagi D., Mosmann T.R. CD8Tc1 and Tc2 cells secrete distinct cytokine patterns in vitro and in vivo but induce similar inflammatory reactions. J. Immunol. 158:1997;4152-4161.
29. Marker O., Volkert M. Studies on cell-mediated immunity to lymphocytic choriomeningitis virus in mice. J. Exp. Med. 137:1973;1511-1525.
30. Marker O., Thomsen A.R., Volkert M., Hansen B.L., Clemmensen I.H. High-dose survival in the lymphocytic choriomeningitis virus infection is accompanied by suppressed DTH but unaffected T cell cytotoxicity. Scand. J. Immunol. 21:1985;81-91.
31. Marker O., Scheynius A., Christensen J.P., Thomsen A.R. Virus-activated T cells regulate expression of adhesion molecules on endothelial cells in sites of infection. J. Neuroimmunol. 62:1995;35-42.
32. McIntyre K.W., Welsh R.M. Accumulation of natural killer and cytotoxic T large granular lymphocytes in the liver during virus infection. J. Exp. Med. 164:1986;1667-1681.
33. Nansen A., Christensen J.P., Marker O., Thomsen A.R. Sensitization to lipopolysaccharide in mice with asymptomatic viral infection: role of T cell-dependent production of interferon-γ J. Infect. Dis. 176:1997;151-157.
34. + T cells facilitates homing to inflammatory sites. J. Immunol. 153:1994;2021-2028.
35. Pakala S.V., Kurrer M.O., Katz J.D. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J. Exp. Med. 186:1997;299-306.
36. Pevear D.C., Melio F., Pfau C.J. Lymphocytic choriomeningitis virus-induced disease of the central nervous system and the 'antigen-sink' hypothesis. Med. Microbiol. Immunol. 175:1986;205-208.
37. Sandberg K., Kemper P., Stalder A., Zhang J., Hobbs M.V., Whitton J.L.C.I.L. Altered tissue distribution of viral replication and T cell spreading is pivotal in the protection against fatal lymphocytic choriomeningitis in mice after neutralization of IFN-α/β J. Immunol. 153:1994;220-231.
38. Saulnier M., Huang S., Aguet M., Ryffel B. Role of interferon-γ in contact hypersensitivity assessed in interferon-γ receptor-deficient mice. Toxicology. 102:1995;301-312.
39. Schulz M., Aichele P., Schneider R., Hansen T.H., Zinkernagel R.M. Major histocompatibility complex binding and T cell recognition of a viral nonapeptide containing a minimal tetrapeptide. Eur. J. Immunol. 21:1991;1181-1185.
40. Thomsen A.R., Marker O. MHC and non-MHC genes regulate elimination of lymphocytic choriomeningitis virus and antiviral cytotoxic T lymphocyte and delayed-type hypersensitivity mediating T lymphocyte activity in parallel. J. Immunol. 142:1989;1333-1341.
41. Thomsen A.R., Volkert M., Marker O. The timing of the immune response in relation to virus growth determines the outcome of the LCM infection. APMIS C. 87:1979;47-54.
42. Tosolini F.A., Mims C.A. Effect of murine strain and viral strain on the pathogenesis of lymphocytic choriomeningitis infection and a study of footpad responses. J. Infect. Dis. 123:1971;134-144.
43. Utermohlen O., Dangel A., Tarnok A., Lehmann-Grube F. Modulation by interferon-γ of antiviral cell-mediated immune responses in vivo. J. Virol. 70:1996;1521-1526.
44. Wille A., Gessner A., Lother H., Lehmann-Grube F. Mechanism of recovery from acute virus infection: VIII. Treatment of lymphocytic choriomeningitis virus-infected mice with anti-interferon-γ monoclonal antibody blocks generation of virus-specific cytotoxic T lymphocytes and virus elimination. Eur. J. Immunol. 19:1989;1283-1288.
45. + lymphocytes during an acute viral infection. J. Exp. Med. 169:1989;2159-2171.
46. Zinkernagel R.M. H-2 restriction of virus-specific T cell-mediated effector functions in vivo: II. Adoptive transfer of delayed-type hypersensitivity to murine lymphocytic choriomeningits virus is restricted by the K and D region of H-2. J. Exp. Med. 144:1976;776-787.