Prevention of primary islet isograft nonfunction in mice with pravastatin

Transplantation

Volumn 65, Issue 11, 1998, Pages 1429-1433

  Arita, Seiji ^a   Une, Satoshi ^a   Ohtsuka, Satoki ^a   Atiya, Azmi ^a   Kasraie, Ali ^a   Shevlin, Linda ^a   Mullen, Yoko ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; NICOTINAMIDE; PRAVACOL; PRAVASTATIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CELL PROTECTION; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE TOLERANCE TEST; GRAFT VERSUS HOST REACTION; INFLAMMATORY CELL; KILLER CELL; MONONUCLEAR CELL; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PANCREAS FUNCTION; PANCREAS ISLET CELL; PANCREAS TRANSPLANTATION; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE TOLERANCE TEST; GLYCOSURIA; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, INBRED BALB C; PRAVASTATIN; TRANSPLANTATION, ISOGENEIC;

EID: 0032525860     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199806150-00003     Document Type: Article

References (23)

1. Nagata M, Mullen Y, Matsuo S, Herrera M, Clare-Salzler M. Destruction of islet isografts by severe nonspecific inflammation. Transplant Proc 1990; 22: 855.
2. Kaufman DB, Platt JL, Rabe FL, Dunn DL, Bach FH, Sutherland DER. Differential roles of Mac-1+ cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts. J Exp Med 1990; 172: 291.
3. Mandrup-Poulsen T, Spinas GA, Prowse SJ, et al. Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics. Diabetes 1987; 36: 641.
4. Pukel C, Baquerizo H, Rabinovitch A. Destruction of rat islet cell monolayers by cytokines: synergistic interactions of interferon-γ, tumor necrosis factor, lymphotoxin, and interleukin 1. Diabetes 1988; 37: 133.
5. Kroncke KD, Bachofen VK, Berschick B, Burkart V, Kolb H. Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation. Biochem Biophys Res Commun 1991; 175: 752.
6. Tsujita Y, Watanabe Y. Pravastatin sodium: a novel cholesterol-lowering agent that inhibits HMG-CoA reductase. Cardiovasc Drug Res 1989; 7: 110.
7. Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature 1990; 343: 425.
8. Chakrabarti R, Engleman EG. Interrelationship between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation. J Biol Chem 1991; 266: 12216.
9. Cutts JL, Scallen TJ, Watson J, Bankhurst AD. Role of mevalonic acid in the regulation of natural killer cell cytotoxicity. J Cell Physiol 1989; 139: 550.
10. Kreuzer J, Bader J, Jahn L, Hautmann M, Kübler W, Hodenberg EV. Chemotaxis of the monocyte cell line U937: dependence on cholesterol and early mevalonate pathway products. Atherosclerosis 1991; 90: 203.
11. Kobashigawa JA, Katznelson S, Laks H, et al. Effect of pravastatin on outcomes after cardiac transplantation. N Engl J Med 1995; 333: 621.
12. Katznelson S, Wilkinson AH, Kobashigawa JA, et al. The effect of pravastatin on acute rejection after kidney transplantation: a pilot study. Transplantation 1996; 61: 1469.
13. Yamada K, Ryu E, Nonaka K. Protective effect of nicotinamide and β-aminobenzamide on islet cell damage induced by γ-interferon and tumor necrosis factor. Diabetes Res 1990; 13: 85.
14. Anderson HU, Jorgensen KH, Egeberg J, Mandrup-Poulsen T, Nerup J. Nicotinamide prevents interleukin-1 effects on accumulated insulin release and nitric oxide production in rat islets of Langerhans. Diabetes 1994; 43: 770.
15. Kröncke KD, Funda J, Berschick B, Kolb H, Kolb-Bachofen V. Macrophage cytotoxicity towards isolated rat islet cells: neither lysis nor its protection by nicotinamide are β-cell specific. Diabetologia 1991; 34: 232.
16. Kenmochi T, Miyamoto M, Mullen Y. Protection of mouse islet isografts from nonspecific inflammatory damage by recipient treatment with nicotinamide and 15-deoxyspergualin. Cell Transplant 1996; 5: 41.
17. Kaufman DB, Gores PF, Field MJ, et al. Effect of 15-deoxyspergualin on immediate function and long-term survival of transplanted islets in murine recipients of a marginal islet mass. Diabetes 1994; 43: 778.
18. Rabinovitch A, Suarez WL, Thomas PD, Strynadka K, Simpson I. Cytotoxic effects of cytokines on rat islets: evidence for involvement of free radicals and lipid peroxidation. Diabetologia 1992; 35: 409.
19. Jungnickel PW, Cantral KA, Maloley PA. Pravastatin: a new drug for the treatment of hypercholesterolemia. Clin Pharm 1992; 11: 677.
20. Rubenfire M, Maciejko JJ, Blevins RD, Orringer C, Kobylak L, Rosman H. The effect of pravastatin on plasma lipoprotein and apolipoprotein levels in primary hypercholesterolemia. Arch Intern Med 1991; 151: 2234.
21. Kakkis JL, Ke B, Dawson S, et al. Pravastatin increases survival and inhibits natural killer cell enhancement factor (NKEF) in liver transplanted rats. J Surg Res 1997; 69: 393.
22. Gray DWR, Sutton R, McShane P, Peters M, Morris PJ. Exocrine contamination impairs implantation of pancreatic islets transplanted beneath the kidney capsule. J Surg Res 1988; 45: 432.
23. Hole RL, Pian-Smith MCM, Sharp GWG. Development of the biphasic response to glucose in fetal and neonatal rat pancreas. Am J Physiol 1988; 254: E167.