Hepatocyte-catalysed detoxification of cyanide by L- and D-cysteine

Biochemical Pharmacology

Volumn 55, Issue 12, 1998, Pages 1983-1990

  Huang, James ^a   Niknahad, Hossein ^a   Khan, Sumsullah ^a   O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Mercaptopyruvate; Cysteine; Thiocyanate; Thiocystine; Thiosulfate

Indexed keywords

3 MERCAPTOPYRUVIC ACID; AMINOOXYACETIC ACID; BENZOIC ACID; CYANIDE; CYSTEINE; CYSTINE; GLUTATHIONE; PROPARGYLGLYCINE; THIOCYANATE; THIOSULFATE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; DRUG MECHANISM; DRUG TRANSFORMATION; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CYANIDES; CYSTEINE; CYSTINE; LIVER; MALE; METABOLIC DETOXICATION, DRUG; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY; THIOCYANATES;

EID: 0032525749     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00072-0     Document Type: Article

References (34)

1. Vennesland B, Castric PA, Conn EE, Solomonson LP, Violini M, Westley J. Cyanide metabolism. Fedn Proc. 41:1982;2639-2648.
2. Jarabak R. 3-Mercaptopyruvate sulfurtransferase. Methods Enzymol. 77:1981;291-297.
3. Mousa HM, Davis RH. Alternative sulfur donor for detoxification of cyanide in the chicken. Comp Biochem Physiol C. 99:1991;309-315.
4. Porter DW, Nealley EW, Baskin SI. In vivo detoxification of cyanide by cystathionase γ-lyase. Biochem Pharmacol. 52:1996;941-944.
5. Willhite CC, Ferm VH, Smith RP. Teratogenic effects of aliphatic nitriles. Teratology. 23:1981;317-323.
6. Benz FW, Nerland DE, Pierce WM, Babiuk C. Acute acrylonitrile toxicity Studies on the mechanism of the antidotal effect of D- and L-cysteine and their N-acetyl derivatives in the rat . Toxicol Appl Pharmacol. 102:1990;142-150.
7. Mehta C. Antidotal effect of sodium thiosulfate in mice exposed to acrylonitrile. Res Commun Mol Pathol Pharmacol. 87:1995;155-165.
8. Niknahad H, O'Brien PJ. Antidotal effect of dihydroxyacetone against cyanide toxicity in vivo. Toxicol Appl Pharmacol. 138:1996;186-191.
9. Niknahad H, Khan S, Sood C, O'Brien PJ. Prevention of cyanide-induced cytotoxicity by nutrients in isolated rat hepatocytes. Toxicol Appl Pharmacol. 128:1994;271-279.
10. Moldeus P, Hogberg J, Orrenius S. Isolation and use of liver cells. Methods Enzymol. 52:1978;60-71.
11. Khan S, O'Brien PJ. 1-Bromoalkanes as new potent nontoxic glutathione depleters in isolated rat hepatocytes. Biochem Biophys Res Commun. 179:1991;436-441.
12. Westley J. Thiocyanate and thiosulfate. Methods Enzymol. 143:1987;22-25.
13. Crompton M, Palmieri F, Capano M, Quaglianrello E. The transport of thiosulfate in rat liver mitochondria. FEBS Lett. 46:1974;247-250.
14. Bannai S. Transport of cystine and cysteine in mammalian cells. Biochim Biophys Acta. 779:1984;289-306.
15. Bitner RS, Vim GK, Isom GE. 2-Iminothiazolidine-4-carboxylic acid produces hippocampal CA1 lesions. Neurotoxicology. 18:1997;191-200.
16. Niknahad H, Khan S, O'Brien PJ. Oxygen dependence of hepatocyte susceptibility to mitochondrial respiratory inhibitors. Biochem Pharmacol. 50:1995;1859-1865.
17. Rognstod R, Clark DG. Effects of aminooxyacetate on the metabolism of isolated liver cells. Arch Biochem Biophys. 161:1974;638-646.
18. Fonda ML, Anderson BM. D-Amino acid oxidase. J Biol Chem. 243:1968;1931-1935.
19. Cavallini D, De Marco C, Dupre S, Rotilio G. The copper catalyzed oxidation of cysteine to cystine. Arch Biochem Biophys. 130:1969;354-361.
20. Westley J. Rhodanese. Adv Enzymol. 39:1973;327-368.
21. Uhteg LC, Westley J. Purification and steady-state kinetic analysis of yeast thiosulfate reductase. Arch Biochem Biophys. 195:1979;211-222.
22. Villarejo M, Westley J. Mechanism of rhodanese catalysis of thiosulfate-lipoate oxidation-reduction. J Biol Chem. 238:1963;4016-4020.
23. Koj A, Frendo J, Janik Z. Thiosulfate oxidation by rat liver mitochondria in the presence of GSH. Biochem J. 103:1967;791-795.
24. Huang J, Khan S, O'Brien PJ. The glutathione dependence of inorganic sulfate formation from L- or D-cysteine in isolated rat hepatocytes. Chem Biol Interact. 110:1998;189-202.
25. Fiedler H, Wood JL. Specificity studies on the β-mercaptopyruvate-cyanide transsulfuration system. J Biol Chem. 222:1956;387-397.
26. Kun E, Fanshier DW. Enzymic transfer of sulfur from β-mercaptopyruvate to cyanide. Biochim Biophys Acta. 33:1959;26-28.
27. Kun E, Fanshier DW. Isolation and properties of a β-mercaptopyruvate-cleaving copper enzyme. Biochim Biophys Acta. 32:1959;338-348.
28. Abdolrasulnia R, Wood JL. Transfer of persulfide sulfur from thiocystine to rhodanese. Biochim Biophys Acta. 567:1979;135-143.
29. Szczepkowski TW, Wood JL. The cystathionase-rhodanese system. Biochim Biophys Acta. 139:1967;469-478.
30. Drake MR, De La Rosa J, Stipanuk MH. Metabolism of cysteine in rat hepatocytes. Evidence for cysteinesulphinate-independent pathways. Biochem J. 244:1987;279-286.
31. 6 Pyridoxal Phosphate, Part B. 1986;311-323 John Wiley, Toronto.
32. 6 Pyridoxal Phosphate, Part B. 1986;507-572 John Wiley, Toronto.
33. Costa MT, Wolf AM, Giarnieri D. Cleavage of cystine by cystathionase. Enzymologia. 43:1972;271-279.
34. Yamanishi T, Tuboi S. The mechanism of the L-cystine cleavage reaction catalyzed by rat liver γ-cystathionase. J Bio chem (Tokyo). 89:1981;1913-1921.