Control of oxidative phosphorylation, gluconeogenesis, ureagenesis and ATP turnover in isolated perfused rat liver analyzed by top-down metabolic control analysis

European Journal of Biochemistry

Volumn 254, Issue 1, 1998, Pages 194-201

  Soboll, Sibylle ^a   Oh, Myung Hee ^a   Brown, Guy C ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Metabolic control analysis; Mitochondria; Perfused rat liver

Indexed keywords

3 HYDROXYBUTYRIC ACID; ADENOSINE TRIPHOSPHATE; AMMONIA; AMOBARBITAL; GLUCOSE; LACTIC ACID; NORVALINE; QUINOLINIC ACID; UREA;

ANIMAL TISSUE; ARTICLE; ELECTRON TRANSPORT; ENERGY CONSUMPTION; GLUCONEOGENESIS; LIVER MITOCHONDRION; MALE; METABOLIC REGULATION; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; REACTION TIME; STEADY STATE; UREA CYCLE;

ANIMALIA;

EID: 0032524049     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2540194.x     Document Type: Article

References (25)

1. Brown, G. C. (1992) Control of respiration and ATP synthesis in mammalian mitochondria and cells, Biochem. J. 284, 1-13.
2. Brown, G. C., Hafner, R. P. & Brand, M. D. (1990) A top-down approach to the determination of control coefficients in metabolic control theory, Eur. J. Biochem. 188, 321-325.
3. Atkinson, D. E. (1977) Cellular energy metabolism and its regulation, Academic Press, New York.
4. Kacser, H. & Burns, J. A. (1973) The control of flux, Symp. Soc. Exp. Biol. 27, 65-104.
5. Heinrich, R. & Rapoport, T. A. (1974) A linear steady-state treatment of enzymatic chains - general properties, control and effector strength, Eur. J. Biochem. 42, 89-95.
6. Groen, A. K., Wanders, R. J. A., Westerhoff, H. V., van der Meer, R. & Tager, J. M. (1982) Quantification of the contribution of various steps to the control of mitochondrial respiration, J. Biol. Chem. 257, 2754-2757.
7. Brand, M. D. (1996) Top down metabolic control analysis, J. Theor. Biol. 182, 351-360.
8. Hafner, R. P., Brown, G. C. & Brand, M. D. (1990) Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and protonmotive force in isolated mitochondria using the topdown approach of metabolic control theory, Eur. J. Biochem. 188, 313-319.
9. Brown, G. C., Lakin-Thomas, P. L. & Brand, M. D. (1990) Control of respiration and oxidative phosphorylation in isolated rat liver cells, Eur. J. Biochem. 192, 355-362.
10. Cornish-Bowden, A. & Hofmeyr, J. H. S. (1994) Determination of control coefficients in intact metabolic systems, Biochem. J. 298, 367-375.
11. Brown, G. C. (1995) Control and regulation in bioenergetics, IRL Press, Oxford.
12. Scholz, R., Hansen, W. & Thurman, R. G. (1973) Interaction of mixed-function oxidation with biosynthetic processes, Eur. J. Biochem. 38, 64-72.
13. Krebs, H. A. & Henseleit, K. (1932) Untersuchungen über die Harnstoffbildung im Tierkörper, Hoppe-Seyler's Z. Physiol. Chem. 210, 33-66.
14. Bergmeyer, H. U. (1974) Methoden der Enzymatischen Analyse, 3. Auflage, Verlag Chemie, Weinheim.
15. Fell, D. A. & Sauro, H. M. (1985) Metabolic control and its analysis, Eur. J. Biochem. 148, 555-561.
16. Giersch, Ch. (1988) Control analysis of metabolic networks, Eur. J. Biochem. 174, 509-513.
17. Sies, H. (1982) Nicotinamide nucleotide compartmentation, in Metabolic compartmentation (Sies, H., ed.) pp 206-231, Academic-Press, New York.
18. Cheung, C-W., Cohen, N. & Raijman, L. (1989) Channeling of urea cycle intermediates in situ in permeabilized hepatocytes, J. Biol. Chem. 264, 4038-4044.
19. Chamalaun, R. A. F. M. & Tager, J. M. (1970) Nitrogen metabolism in the perfused rat liver, Biochim. Biophys. Acta 222, 119-134.
20. Scholz, R., Hansen, W. & Thurman, R. G. (1973) Interaction of mixed-function oxidation with biosynthetic processes, Eur. J. Biochem. 38, 64-72.
21. Marshall, M. & Cohen, P. (1972) Ornithine transcarbamylase from Streptococcus faecalis and bovine liver. J. Biol. Chem. 247, 1654-1668.
22. Fell, D. A. (1992) Metabolic control analysis: a survey of its theoretical and experimental development, Biochem. J. 286, 313-330.
23. Korzeniewski, B., Harper, M. E. & Brand, M. (1995) Proportional activation coefficients during stimulation of oxidative phosphorylation by lactate and pyruvate or by vasopressin, Biochim. Biophys. Acta 1229, 315-322.
24. Soboll, S., Scholz, R. & Heldt, H. W. (1978) Subcellular metabolite concentrations; dependence of mitochondrial and cytosolic ATP systems on the metabolic state of perfused rat liver, Eur. J. Biochem. 87, 377-390.
25. Buttergereit, F. & Brand, M. D. (1995) A hierarchy of ATP-consuming processes in mammalian cells, Biochem. J. 312, 163-167.