Projection patterns from the raphe nuclear complex to the ependymal wall of the ventricular system in the rat

Journal of Comparative Neurology

Volumn 399, Issue 1, 1998, Pages 61-72

  Simpson, Kimberly L ^a   Fisher, Todd M ^a   Waterhouse, Barry D ^a   Lin, Rick C S ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Fluorescent tracers; Nicotinamide adenine dinucleotide phosphate diaphorase; Raphe nuclei; Serotonin; Ventricle

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SEROTONIN;

ANIMAL TISSUE; ARTICLE; BRAIN LATERAL VENTRICLE; BRAIN VENTRICLE; EPENDYMA; FEMALE; FLUORESCENCE ANALYSIS; MALE; NERVE PROJECTION; NEUROANATOMY; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; SEROTONINERGIC NERVE CELL;

ANIMALS; BRAIN CHEMISTRY; EPENDYMA; FEMALE; MALE; NADPH DEHYDROGENASE; NEURAL PATHWAYS; NEURONS; RAPHE NUCLEI; RATS; RATS, LONG-EVANS; SEROTONIN; THALAMIC NUCLEI;

EID: 0032517149     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9861(19980914)399:1<61::AID-CNE5>3.0.CO;2-8     Document Type: Article

References (46)

1. Aghajanian, G.K. and D.W. Gallager (1975) Raphe origin of serotonergic nerves terminating in the cerebral ventricles. Brain Res. 88:221-231.
2. Azmitia, E.J. and M. Segal (1978) An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179:641-688.
3. Belin, M.F., D. Nanopoulos, M. Dider, M. Aguera, H. Steinbusch, A. Verhofstad, H. Maitre, and J.F. Pujol (1983) Immunohistochemical evidence for the presence of gamma-aminobutyric acid and serotonin in one nerve cell. A study on the raphe nuclei of the rat using antibodies to glutamate decarboxylase and serotonin. Brain Res. 275:329-339.
4. Bonvento, G., P. Lacombe, and J. Seylaz (1989) Effects of electrical stimulation of the dorsal raphe nucleus on local cerebral blood flow in the rat. J. Cerebral Blood Flow Metabol. 9:251-255.
5. Bruni, J.E., M.R. Del Bigio, and R.E. Clattenburg (1985) Ependyma: Normal and pathological. A review of the literature. Brain Res. Rev. 9:1-19.
6. Cao, W.H., A. Sato., A.P.M. Yusof, and W. Zhou (1992) Regulation of regional blood flow in cerebral cortex by serotonergic neurons originating in the dorsal nucleus in the rat. Biogenic Amines 8:351-360.
7. Chan-Palay, V. (1976) Serotonin axons in the supra-and subependymal plexuses and in the leptomeninges, their roles in local alteration of cerebrospinal fluid and vasomotor activity. Brain Res.102:103-130.
8. Cloft, H.J. and J.A. Mitchell (1997) Serotonergic innervation of the supraependymal neuronal complex of the golden hamster. Brain Res. 761:210-216.
9. Cohen, Z., M. Ehret, M. Maitre, and E. Hamel (1995) Ultrastructural analysis of tryptophan hydroxylase immunoreactive nerve terminals in the rat cerebral cortex and hippocampus: Their association with local blood vessels. Neuroscience 66:555-569.
10. Conn, P.J., A. Janowsky, and E. Sanders-Bush (1987) Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus. Brain Res. 400:396-398.
11. Cudennec, A., G. Bonvento, D. Duverger, P. Lacombe, J. Seylaz, and E. MacKenzie (1993) Effects of dorsal raphe nucleus stimulation on cerebral blood flow and flow-metabolism coupling in the conscious rat. Neuroscience 55:395-401.
12. Dawson, V.L., T.M. Dawson, E.D. London, D.S. Bredt, and S.H. Snyder (1991) Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA 88:6398-6371.
13. Del Bigio, M.R. (1995) The ependyma: A protective barrier between brain and cerebrospinal fluid. Glia 14:1-13.
14. de Olmos, L.E. and L. Heimer (1980) Double and triple labelling of neurons with fluorescent substances: The study of collateral pathways in the ascending raphe system. Neurosci. Lett. 19:7-12.
15. Fessler, R.D., J.C. Hazlett, and J.A. Mitchell (1990) Correlative scanning and transmission electron microscopy of the supraependymal neuronal complex in the hamster third ventricle following radiofrequency lesion of the midbrain raphe nuclei. Soc. Neurosci. Abstr. 16:1033.
16. Friedlander, M.J., F.W. Hester, C.D. Gancayco, B.D. Waterhouse, and R.C.S. Lin (1995) The role of the ascending serotonergic system in cortical nitric oxide production. Soc. Neurosci. Abstr. 21:1753.
17. Giordano, J. and P. Hartig (1987) Activation and regulation of the serotonin 5HT-1c receptor on the choroid plexus by CSF-borne serotonin. Soc. Neurosci. Abstr. 13:1236.
18. Hawkes, R. and R.W. Turner (1994) Compartmentation of NADPH-diaphorase activity in the mouse cerebellar cortex. J. Comp. Neurol. 346:499-516.
19. Hope, B.T., G.J. Michael, K.M. Knigge, and S.R. Vincent (1991) Neuronal NADPH-diaphorase is a nitric oxide synthase. Proc. Natl. Acad. Sci. USA 88:2811-2814.
20. Jacobs, B.L. and E.C. Azmitia (1992) Structure and function of the brain serotonin system. Physiol. Rev. 72:165-229.
21. Jacobs, B.L., S.L. Foote, and F.E. Bloom (1978) Differential projections of neurons within the dorsal raphe nucleus of the rat: A horseradish peroxidase (HRP) study. Brain Res. 147:149-153.
22. Larsen, P.J., A. Hay-Schmidt, N. Vrang, and J.D. Mikkelsen (1996) Origin of projections from the midbrain raphe nuclei to the hypothalamic paraventricular nucleus in the rat: A combined retrograde and anterograde tracing study. Neuroscience 70:963-988.
23. Lidov, H.G. and M.E. Molliver (1982) Immunohistochemical study of the development of serotonergic neurons in the rat CNS. Brain Res. Bull. 9:559-564.
24. Lorez, H.P. and J.G. Richards (1975) 5-HT nerve terminals in the fourth ventricle of the rat brain: The identification and distribution studied by fluorescence histochemistry and electron microscopy. Cell Tissue Res. 165:37-48.
25. McBean, D.E., J. Sharkey, I.M. Ritchie, and P. Kelly (1990) Evidence for a possible role for serotonergic systems in the control of cerebral blood flow. Brain Res. 537:307-310.
26. McBean, D.E., J. Sharkey, I.M. Ritchie, and P. Kelly (1991) Cerebrovascular and functional consequences of 5-HT1A receptor activation. Brain Res. 555:159-163.
27. Mikkelsen, J.D., A. Hay-Schmidt, and P.J. Larsen (1997) Central innervation of the rat ependyma and subcommissural organ with special reference to ascending serotoninergic projections from the raphe nuclei. J. Comp. Neurol. 384:556-568.
28. Mitchell, J.A. and J.P. Card (1978) Supraependymal neurons overlying the periventricular region of the third ventricle of the guinea pig: A correlative scanning-transmission electron microscopic study. Anat. Rec. 192:441-458.
29. Nanopoulos, D., M.F. Belin, M. Maitre, G. Vincendon, and J.F. Pujol (1982) Immunocytochemical evidence for the existence of GABAergic neurons in the nucleus raphe dorsalis. Possible existence of neurons containing serotonin and GABA. Brain Res. 232:375-389.
30. Paxinos, G. and C. Watson (1982) The Rat Brain in Stereotaxic Coordinates. New York: Academic Press.
31. Peters, A., S.L. Palay, and H.d.F. Webster (1991) The Fine Structure of the Nervous System. Neurons and Their Supporting Cells, 3rd ed. New York: Oxford University Press.
32. Petrov, T., T.L. Krukoff, and J.H. Jhamandas (1992) The hypothalamic paraventricular and lateral parabrachial nuclei receive collaterals from raphe nucleus neurons: A combined double retrograde and immunocytochemical study. J. Comp. Neurol. 318:18-26.
33. Richards, J.G., H.P. Lorez, and J.P. Tranzer (1973) Indolealkylamine nerve terminals in cerebral ventricles: Identification by electron microscopy and fluorescence histochemistry. Brain Res. 57:277-288.
34. Rodrigo, J., V. Riveros-Moreno, M.L. Bentura, L.O. Uttenthal, E.A. Higgs, A.P. Fernadez, J.M. Polak, S. Moncada, and R. Martinez-Murillo (1997) Subcellular localization of nitric oxide synthase in the cerebral ventricular system, subfornical organ, area postrema, and blood vessels of the rat brain. J. Comp. Neurol. 378:522-534.
35. Sancesario, G., M. Morello, R. Massa, F.R. Fusco, V. D'Angelo, and G. Bernardi (1996) NADPH-diaphorase neurons contacting the cerebrospinal fluid in the ventricles of rat brain. J. Cerebral Blood Flow Metabol. 16:517-522.
36. Sawchenko, P.E., L.W. Swanson, H.W.M. Steinbusch, and A.A.J. Verhofstad (1983) The distribution and cells of origin of serotonergic inputs to the paraventricular and supraoptic nuclei of the rat. Brain Res. 277:355-360.
37. Simpson, K.L., R.C.S. Lin, and B.D. Waterhouse (1997) Ipsilateral serotonergic projections from the dorsal raphe nucleus (DR) innervate the lateral ventricles in rat. Soc. Neurosci. Abstr. 23:1219.
38. Steinbusch, H.W.M. (1981) Distribution of serotonin-immunoreactivity in the central nervous system of the rat: Cell bodies and terminals. Neuroscience 6:557-618.
39. Underwood, M.D., M.J. Bakalian, V. Arangao, R.W. Smith, and J.J. Mann (1992) Regulation of cortical blood flow by the dorsal raphe nucleus: Topographic organization of cerebrovascular regulatory regions. J. Cerebral Blood Flow Metabol. 12:664-673.
40. Vincent, S.R. and H. Kimura (1992) Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 46:755-784.
41. Waterhouse, B.D., G.S. Mihailoff, J.C. Baack, and D.J. Woodward (1986) Topographic distribution of dorsal and median raphe neurons projecting to motor, sensorimotor and visual cortical areas in the rat. J. Comp. Neurol. 249:460-481.
42. Waterhouse, B.D., B. Border, L. Wahl, and G.A. Mihailoff (1993) Topographic organization of rat locus coeruleus and dorsal raphe nuclei: Distribution of cells projecting to visual system structures. J. Comp. Neurol. 336:345-361.
43. Wilson, M.A. and M.E. Molliver (1991) The organization of serotonergic projections to cerebral cortex in primates: Regional distribution of axon terminals. Neuroscience 44:537-553.
44. Wotherspoon, G., M. Albert, M. Rattray, and J.V. Priestley (1994) Serotonin and NADPH-diaphorase in the dorsal raphe nucleus of the adult rat. Neurosci. Lett. 173:31-36.
45. Xu, Z.-Q.D. and T. Hökfelt (1997) Expression of galanin and nitric oxide synthase in subpopulations of serotonin neurons of the rat dorsal raphe nucleus. J. Chem. Neuroanat. 13:169-187.
46. Zhou, F.C. and J.-H. Tao-Cheng (1997) Distribution of serotonin transporter in the brain. Soc. Neurosci. Abstr. 23:405.