Structural requirements for outside-in and inside-out signaling by Drosophila neuroglian, a member of the L1 family of cell adhesion molecules

Journal of Cell Biology

Volumn 142, Issue 1, 1998, Pages 251-261

  Hortsch, Michael ^a   Homer, Diahann ^a   Malhotra, Jyoti Dhar ^a   Chang, Sherry ^a   Frankel, Jason ^b   Jefford, Gregory ^b   Dubreuil, Ronald R ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Ankyrins; Cell aggregation; Cells; Cultured; Cytoskeleton; Drosophila

Indexed keywords

ANKYRIN; CELL ADHESION MOLECULE;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL AGGREGATION; CYTOSKELETON; DROSOPHILA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; ANKYRINS; BINDING SITES; CELL ADHESION; CELL ADHESION MOLECULES, NEURONAL; CELL LINE; CONSERVED SEQUENCE; CYTOPLASM; DROSOPHILA; DROSOPHILA PROTEINS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 0032514147     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.142.1.251     Document Type: Article

References (36)

1. Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl. 1988. Current Protocols in Molecular Biology. J. Wiley & Sons, Inc., New York.
2. Bartel, P.L., C.-t. Chien, R. Sternglanz, and S. Fields. 1993. Using the two-hybrid system to detect protein-protein interactions. In Cellular Interactions in Development: A Practical Approach. D.A. Hartley, editor. IRL Press, Oxford, UK. 153-179.
3. Bieber, A.J. 1994. Analysis of cellular adhesion in cultured cells. In Drosophila melanogaster: Practical Uses in Cell Biology. L. Goldstein and E. Fyrberg, editors. 44:683-696. Academic Press, San Diego, CA.
4. Bieber, A.J., P.M. Snow, M. Hortsch, N.H. Patel, J.R. Jacobs, Z.R. Traquina, J. Schilling and C.S. Goodman. 1989. Drosophila neuroglian: a member of the immunoglobulin superfamily with extensive homology to the vertebrate neural adhesion molecule L1. Cell. 59:447-460.
5. Boulton, T.G., S.H. Nye, D.J. Robbins, N.Y. Ip, E. Radziejewska, S.D. Morgenbesser, R.A. DePinho, N. Panayotatos, M.H. Cobb, and G.D. Yancopoulos. 1991. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 65:663-675.
6. Clark, E.A., and J.S. Brugge. 1995. Integrins and signal transduction pathways: the road taken. Science. 268:233-239.
7. Dahme, M., U. Bartsch, R. Martini, B. Anliker, M. Schachner, and N. Mantei. 1997. Disruption of the mouse L1 gene leads to malformations of the nervous system. Nat. Genet. 17:346-349.
8. Davis, J.Q., and V. Bennett. 1994. Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. J. Biol. Chem. 269:27163-27166.
9. Davis, J.Q., T. McLaughlin, and V. Bennett. 1993. Ankyrin-binding proteins related to nervous system cell adhesion molecules: candidates to provide transmembrane and intercellular connections in adult brain. J Cell Biol. 121:121-133.
10. Dubreuil, R.R., and J.-Q. Yu. 1994. Ankyrin and beta-spectrin accumulate independently of alpha-spectrin in Drosophila. Proc. Natl. Acad. Sci. USA. 91: 10285-10289.
11. Dubreuil, R.R., T.J. Byers, D. Branton, L.S.B. Goldstein, and D.P. Kiehart. 1987. Drosophilia spectrin. I. Characterization of the purified protein. J. Cell Biol. 105:2095-2102.
12. Dubreuil, R.R., G. MacVicar, S. Dissanayake, C. Liu, D. Homer, and M. Hortsch. 1996. Neuroglian-mediated cell adhesion induces assembly of the membrane skeleton at cell contact sites. J. Cell Biol. 133:647-655.
13. Dubreuil, R.R., P.B. Maddux, T.A. Grushko, and G.R. MacVicar. 1997. Segregation of two spectrin isoforms: polarized membrane-binding sites direct polarized membrane skeleton assembly. Mol. Biol. Cell. 8:1933-1942.
14. Durfee, T., K. Becherer, P.L. Chen, S.H. Yeh, Y. Yang, A.E. Kilburn, W.H. Lee, and S.J. Elledge. 1993. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7:555-569.
15. Garver, T.D., Q. Ren, S. Tuvia, and V. Bennett. 1997. Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin. J. Cell Biol. 137:703-714.
16. Grenningloh, G., E.J. Rehm, and C.S. Goodman. 1991. Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule. Cell. 67:45-57.
17. Gumbiner, B.M. 1995. Signal transduction of beta-catenin. Curr. Opin. Cell Biol. 7:634-640.
18. Hall, S.G., and A.J. Bieber. 1997. Mutations in the Drosophila neuroglian cell adhesion molecule affect motor neuron pathfinding and peripheral nervous system patterning. J. Neurobiol. 32:325-340.
19. Horisch, M. 1996. The L1 family of neural cell adhesion molecules: old proteins performing new tricks. Neuron. 17:587-593.
20. Hortsch, M., D. Avossa, and D.I. Meyer. 1985. A structural and functional analysis of the docking protein. Characterization of active domains by proteolysis and specific antibodies. J. Biol. Chem. 260:9137-9145.
21. Hortsch, M., K.S. O'Shea, G. Zhao, F. Kim, Y. Vallejo, and R.R. Dubreuil. 1998. A conserved role for L1 as a transmembrane link between neuronal adhesion and membrane cytoskeleton assembly. Cell Adh. Comm. 5:61-73.
22. Horisch, M., Y.M. Wang, Y. Marikar, and A.J. Bieber. 1995. The cytoplasmic domain of the Drosophila cell adhesion molecule neuroglian is not essential for its homophilic adhesive properties in S2 cells. J. Biol. Chem. 270:18809-18817.
23. Kamiguchi, H., and V. Lemmon. 1997. Neural cell adhesion molecule L1: signaling pathways and growth cone molility. J. Neurosci. Res. 49:1-8.
24. Lindner, J., F.G. Rathjen, and M. Schaehner. 1983. L1 mono- and polyclonal antibodies modify cell migration in early postnatal mouse cerebellum. Nature. 305:427-430.
25. +)ATPase and implications for the organization of membrane domains in polarized cells. Nature. 328:533-536.
26. Sanger, F., S. Nicklen, and A.R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA. 74:5463-5467.
27. Schlessinger, J., and A. Ullrich. 1992. Growth factor signaling by receptor tyrosine kinases. Neuron. 9:383-391.
28. She, H.-y., S. Rockow, J. Tang, R. Nishimura, E.Y. Skolnik, M. Chen, B. Margolis, and W. Li. 1997. Wiskott-Aldrich Syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells. Mol. Biol. Cell. 8:1709-1721.
29. Tuvia, S., T.D. Garver, and V. Bennett. 1997. The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation. Proc. Natl. Acad. Sci. USA. 94:12957-12962.
30. Vallejo, Y., M. Hortsch, and R.R. Dubreuil. 1997. Ethanol does not inhibit the adhesive activity of Drosophila neuroglian or human L1 in Drosophila S2 tissue culture cells. J. Biol. Chem. 272: 12244-12247.
31. Van Camp, G., E. Fransen, L. Vits, G. Raes, and P.J. Willems. 1996. A locus-specific mutation database for the neural cell adhesion molecule L1CAM (Xq28). Hum. Mutat. 8:391.
32. Walsh, F.S., and P. Doherty. 1997. Neural cell adhesion molecules of the immunoglobulin superfamily: Role in axon growth and guidance. Annu. Rev. Cell Dev. Biol. 13:425-456.
33. Wong, E.V., G.H. Cheng, H.R. Payne, and V. Lemmon. 1995a. The cytoplasmic domain of the cell-adhesion molecule L1 is not required for homophilic adhesion. Neurosci. Lett. 200:155-158.
34. Wong, E.V., S. Kenwrick, P. Willems, and V. Lemmon. 1995b. Mutations in the cell adhesion molecule L1 cause mental retardation. Trends Neurosci. 18: 168-172.
35. Wong, E.V., A.W. Schaefer, G. Landreth, and V. Lemmon. 1996a. Casein kinase-II phosphorylates the neural cell-adhesion molecule L1. J. Neurochem. 66:779-786.
36. Wong, E.V., A.W. Schaefer, G. Landreth, and V. Lemmon. 1996b. Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1. J. Biol. Chem. 271:18217-18223.