Uncoupling proteins: The unravelling of obesity?: Increased understanding of mechanisms may lead, in time, to better drugs

BMJ

Volumn 317, Issue 7173, 1998, Pages 1607-1608

  Berger, Abi ^a   Brand, Martin ^b   O'rahilly, Stephen ^b  

^a BMJ   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; UNCOUPLING PROTEIN;

CHILD; EDITORIAL; GENE EXPRESSION; HUMAN; METABOLIC RATE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; WEIGHT REDUCTION;

DRUG RESISTANCE; ENERGY METABOLISM; HUMANS; LEPTIN; OBESITY; PROTEINS; UNCOUPLING AGENTS;

EID: 0032512295     PISSN: 09598138     EISSN: 14685833     Source Type: Journal    
DOI: 10.1136/bmj.317.7173.1607     Document Type: Editorial

References (4)

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2. Montague CT, Farooqui IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903–908.
3. Fleury C, Neverove M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, et al. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinaemia Nature Genetics 1997; 15: 269–272.
4. Samec S, Seydoux J, Dulloo AG. Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate? FASEB J 1998; 12: 715–724.