Local injection of alkylating and nonalkylating dopamine receptor antagonists into rat basal forebrain: Autoradiographic assessment of D2- like and D3 sites

Brain Research

Volumn 792, Issue 2, 1998, Pages 324-326

  Yeghiayan, S K ^a,b   Gongwer, M A ^a,b   Baldessarini, R J ^a,b   Kula, N S ^a,b   Zong, R ^a,b   Neumeyer, J L ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

7 OH DPAT; Accumbens; Alkylating agent; Autoradiography; D2 like receptor; D3 receptor; Dopamine; EEDQ; Fluphenazine; Islands of Calleja

Indexed keywords

2 ETHOXY 1(2H) QUINOLINECARBOXYLIC ACID ETHYL ESTER; 7 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALENE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; EMONAPRIDE; FLUPHENAZINE; N CHLOROETHYL DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN DEVELOPMENT; DOPAMINE RELEASE; FOREBRAIN; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RAT; RECEPTOR BLOCKING;

ALKYLATING AGENTS; ANIMALS; AUTORADIOGRAPHY; BACTERIAL TOXINS; CALCIUM-BINDING PROTEINS; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; FLUPHENAZINE; MALE; MICROINJECTIONS; NUCLEUS ACCUMBENS; PHOSPHOLIPASE C; PROSENCEPHALON; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; TETRAHYDRONAPHTHALENES;

EID: 0032507728     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00202-9     Document Type: Article

References (14)

1. 3 receptors in rat olfactory tubercle J. Pharmacol. Exp. Ther. 268:1994;935-942.
2. 3 dopamine receptors. Neuropsychopharmacology. 12:1995;335-345.
3. Campbell A., Yeghiayan S.K., Villavicencio A.T., Balikian R., Baldessarini R.J. Mapping of locomotor behavioral arousal induced by microinjections of dopamine within nucleus accumbens septi of the rat forebrain. Brain Res. 771:1997;55-62.
4. 3 receptors Eur. J. Pharmacol. 272:1995;R1-R3.
5. Kebabian J.W., Tarazi F.I., Kula N.S., Baldessarini R.J. Compounds selective for dopamine receptor subtypes. Drug Discov. Today. 2:1997;333-340.
6. N.S. Kula, R.J. Baldessarini, K. Zhang, R. Zong, J.L. Neumeyer, Neuropharmacological characterization of novel alkylating derivatives of 7-OH-DPAT, (1997) submitted for publication.
7. 2 dopaminergic receptors in young vs. adult rat striatal tissue following alkylation with ethoxycarbonyl-ethoxy-dihydroquinoline (EEDQ). Dev. Brain Res. 66:1992;286-289.
8. 3H] 7-OH-DPAT-labeled binding sites in rat brain to inactivation by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinolone Brain Res. 698:1995;146-154.
9. 2 dopamine receptors by 7-OH-DPAT. Synapse. 24:1996;60-64.
10. 3H] 7-hydroxy-N,N-di-n-propyl-2-aminotetralin Proc. Nat. Acad. Sci. USA. 89:1992;8155-8159.
11. 3 receptor agonist 7-OH-DPAT: lack of mesolimbic selectivity. Eur. J. Pharmacol. 264:1994;269-278.
12. L.J. Pellegrino, A.J. Cushman, A Stereotaxic Atlas of the Rat Brain, Meredith Publishing, New York, 1967.
13. Sokoloff P., Schwartz J.C. Novel dopamine receptors half a decade later. TIPS. 16:1995;270-275.
14. 4-like dopamine receptors. Neuropsychopharmacology. 17:1997;186-196.