Synthesis of new α-amino- acids containing the isoxazole moiety

Tetrahedron Letters

Volumn 39, Issue 50, 1998, Pages 9241-9244

  Falorni, Massimo ^a   Giacomelli, Giampaolo ^a   Spanu, Emanuela ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

Amino acids and derivatives; Cycloadditions; Isoxazoles

Indexed keywords

ALPHA AMINO ACID; ISOXAZOLE DERIVATIVE; SERINE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; TECHNIQUE;

EID: 0032506626     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02010-3     Document Type: Article

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6. [3] Some selected example: Coppola GM, Schuster HF. Asymmetric Synthesis: Construction of Chiral Molecules Using Amino Acids. New York: Wiley, 1987. Zhang L, Kauffman GS, Pesti JA, Yin J. J. Org. Chem. 1997;62:6918. Tamagnan G, Neumeyer JL, Gao Y, Wang S, Kula NS, Baldessarini RJ. Biorg. Med. Chem. Lett. 1997;7:337. Gryko D, Jurczak J. Tetrahedron Lett. 1997;38:8275.
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12. 3). Compound 10 was found to be >95% e.e. by chiral GC (Chirasil-L-Val column), after converting to the corresponding methyl ester.