Absolute configuration of phorboxazoles A and B from the marine sponge, Phorbas sp. 2. C43 and complete stereochemistry

Tetrahedron Letters

Volumn 37, Issue 44, 1996, Pages 7879-7880

  Molinski, Tadeusz F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC AGENT; PHORBOXAZOLE A; PHORBOXAZOLE B; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; CIRCULAR DICHROISM; DRUG ISOLATION; DRUG STRUCTURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; SPONGE;

PHORBAS;

EID: 0030605181     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01804-7     Document Type: Article

References (9)

1. 1. Searle, P. A.; Molinski, T. F. J. Am. Chem. Soc. 1995, 117, 8126-8131.
2. -9 M.
3. -6 M) showed cell cycle arrest in S phase (FACS analysis). Hamel, E., National Cancer Institute, U.S.A., personal communication.
4. -5 M) under conditions in which known tubulin binders (eg. colchicine, curacin) gave a positive response. Kokoshka, J.M.; Ireland, C.M.; Barrows, L.R. J. Nat. Prod. 1996, in press. We thank Dr. Louis Barrows, University of Utah, for kindly providing these results.
5. 5. Searle, P.A.; Molinski, T.F.; Leahy, J.; Brzezinski, L.J. J. Am. Chem. Soc. 1996, in press.
6. 6. Eliel, E.L.; Wilen, S.J.; Mander, L.N. In ; Stereochemistry of Organic Compounds, Wiley: New York, 1994; pp 1091.
7. 7. Fodor, G.; Sóti, F. J. Chem. Soc. 1965, 6830-6833
8. 3) δ 37.5 (t), 51.9 (q), 52.2 (q), 58.8 (q), 76.6 (d), 170.4 (s), 171.7 (s).
9. 2COOMe).