The tyrosine-17 residue of Nef in SIVsmmPBj14 is required for acute pathogenesis and contributes to replication in macrophages

Virology

Volumn 244, Issue 2, 1998, Pages 261-272

  Saucier, Michelle ^a   Hodge, Shekema ^c   Dewhurst, Stephen ^c   Gibson, Terri ^a   Gibson, J Phil ^d   McClure, Harold M ^a,b   Novembre, Francis J ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d AGNES SCOTT COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TYROSINE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; LENTIVIRINAE; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MOLECULAR CLONING; MONONUCLEAR CELL; NONHUMAN; PATHOGENESIS; PRIMATE; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

ANIMALIA; LENTIVIRUS; MACACA; MACACA NEMESTRINA; PRIMATES; RNA VIRUSES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS; SUS SCROFA;

EID: 0032503217     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9133     Document Type: Article

References (49)

1. Ahmed-Ansari A., Brodie A. R., Fultz P. N., Anderson D. C., Sell K. W., McClure H. M. Flow microfluorometric analysis of peripheral blood mononuclear cells from nonhuman primates: Correlation of phenotype with immune function. Am. J. Primatol. 17:1989;107-131.
2. Baba T. W., Jeang Y. S., Pennick D., Bronson R., Greene M. F., Ruprecht R. M. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science. 267:1995;1820-1825.
3. Barre-Sinoussi F., Chermann J.-C., Rey F., Nugeyre M. T., Chamaret S., Gruest J., Dauguet C., Axler-Blin C., Vezinet-Brun F., Rouzioux C., Rozenbaum W., Montagnier L. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. 220:1983;868-871.
4. Baur A. S., Sawai E. T., Dazin P., Fantl W. J., Cheng-Mayer C., Peterlin B. M. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity. 1:1994;373-384.
5. Benson R. E., Sanfridson A., Ottinger J. S., Doyle C., Cullen B. R. Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral superinfection. J. Exp. Med. 177:1993;1561-1566.
6. Bukousky A. A., Dorfman J., Weimann A., Gottlinger H. G. Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease. J. Virol. 71:1997;1013-1018.
7. Chakrabarti L., Guyader M., Alizon M., Daniel M. D., Desrosiers R. C., Tiollais P., Sonigo P. Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses. Nature. 328:1987;543-547.
8. Chowers M. Y., Pandori M. W., Spina C. A., Richman D. D., Guatelli J. C. The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. Virology. 212:1995;451-457.
9. Clavel F., Guetard D., Brun-Vezinet F. Isolation of a new human retrovirus from West African patients with AIDS. Science. 233:1986;343-346.
10. Cullen B. R. The role of Nef in the replication cycle of the human and simian immunodeficiency viruses. Virology. 205:1994;1-6.
11. Daniel M. D., Kirchoff F., Czajak S. C., Sehgal P. K., Desrosiers R. D. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science. 258:1992;1938-1941.
12. Deacon N. J., Tsykin A., Solomon A., Smith K., Ludford-Menting M., Hooker D. J., McPhee D. A., Greenway A. L., Ellett A., Chatfield C. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science. 270:1995;988-991.
13. Dewhurst S., Embertson J. E., Anderson D. C., Mullins J. I., Fultz P. N. Sequence analysis and acute pathogenicity of molecularly cloned SIVsmm-pbj14. Nature. 345:1990;636-639.
14. Du Z. J., Lang S. M., Sasseville V. G., Lackner A. A., Illyinskii P. O., Daniel M. D., Jung J. U., Desrosiers R. C. Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell. 82:1995;665-674.
15. Du Z., Illyinski P. O., Sasseville V. G., Newstein M., Lackner A. A., Desrosiers R. C. Requirements for lymphocyte activation by unusual strains of simian immunodeficiency virus. J. Virol. 70:1996;4157-4161.
16. Fletcher T. M. III, Brichacek B., Sharova N., Newman M. A., Stivahtis G., Sharp P. M., Emerman M., Hahn B., Stevenson M. Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(sm). EMBO J. 15:1996;6155-6165.
17. Foster J. L., Anderson S. J., Frazier A. L. B., Garcia J. V. Specific suppression of human CD4 surface expression by Nef from the pathogenic simian immunodeficiency virus SIVmac239open. Virology. 201:1994;373-379.
18. Fultz P. N., McClure H. M., Anderson D. C., Switzer W. M. Identification and biological characterization of an acutely lethal variant of simian immunodeficiency virus from sooty mangabeys (SIV/smm). AIDS Res. Hum. Retroviruses. 5:1989;397-409.
19. Gallo R. C., Salahuddin S. Z., Popovic M., Shearer G. M., Kaplan M., Haynes B. F., Palker T. J., Redfield R., Oleske J., Safai B. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science. 224:1984;500-503.
20. Garcia J. V., Miller A. D. Serine phosphorylation-independent downregulation of cell-surface CD4 by Nef. Nature. 350:1991;508-511.
21. Gavrieli Y., Sherman Y., Ben-Sasson S. A. Identification of programmed cell deathin situ. J. Cell. Biol. 119:1992;493-501.
22. Gelbard H. A., James H. J., Sharer L. R., Perry S. W., Saito Y., Kazee A. M., Blumberg B. M., Epstein L. G. Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol. Appl. Neurobiol. 21:1995;208-217.
23. Greenway A., Azad A., McPhee D. Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines. J. Virol. 69:1995;1842-1850.
24. smmPBj14. Virology. 225:1996a;21-32.
25. Gummuluru S., Novembre F. J., Seshi B., Dewhurst S. SIVsmmPBj14 induces expression of a mucosal integrin on macaque lymphocytes. Virology. 215:1996b;97-100.
26. Hirsch V. M., Olmsted R. A., Murphey-Corb M., Purcell R. H., Johnson P. R. An African primate lentivirus (SIVsm) closely related to HIV-2. Nature. 339:1989;389-392.
27. Israel Z. R., Dean G. A., Maul D. H., O'Neil S. P., Dreitz M. J., Mullins J. I., Fultz P. N., Hoover E. A. Early pathogenesis of disease caused by SIVsmmPBj14 molecular clone 1.9 in macaques. AIDS Res. Hum. Retroviruses. 3:1993;277-286.
28. Kent K. A., Rud E., Corcoran C., Powell C., Thiriart C., Collignon C., Stott E. J. Identification of two neutralizing and 8 non-neutralizing epitopes on simian immunodeficiency virus envelope using monoclonal antibodies. AIDS Res. Hum. Retroviruses. 8:1992;1147-1151.
29. Kestler H. W., Ringler D. J., Mori K., Panicalli D. L., Sehgal P. K., Daniel M. D., Desrosiers R. C. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell. 65:1991;651-662.
30. Kirchoff F., Greenough T. C., Brettler D. B., Sullivan J. L., Desrosiers R. C. Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N. Engl. J. Med. 332:1995;228-232.
31. Letvin N. L., Daniel M. D., Sehgal P. K., Desrosiers R. C., Hunt R. D., Wasdron L. M., MacKey J. J., Schmidt D. K., Chalifoux L. V., King N. W. Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III. Science. 230:1985;71-73.
32. Luciw P. A., Cheng-Mayer C., Levy J. A. Mutational analysis of the human immunodeficiency virus: The orf-B region down-regulates virus replication. Proc. Natl. Acad. Sci. USA. 84:1987;1434-1438.
33. McClure H. M., Anderson D. C., Fultz P. N., Ansari A. A., Lockwood E., Brodie A. Spectrum of disease in macaque monkeys chronically infected with SIV/smm. Vet. Immunol. Immunopath. 21:1989;13-24.
34. Murphey-Corb M., Martin L. N., Rangan S. R. S., Baskin G. B., Gormus B. J., Wold R. H., Andes W. A., West M. Isolation of an HTLV-III retrovirus from macaques with simian AIDS and its possible origin in asymptomatic mangabeys. Nature (London). 321:1986;435-437.
35. Novembre F. J., Hirsch V. M., McClure H. M., Fultz P. N., Johnson P. R. SIV from stump-tailed macaques: Molecular characterization of a highly transmissible primate lentivirus. Virology. 186:1992;783-787.
36. Novembre F. J., Johnson P. R., Lewis M. G., Anderson D. C., Klumpp S., McClure H., Hirsch V. M. Multiple viral determinants contribute to pathogenicity of the acutely lethal simian immunodeficiency virus SIVsmmPBj variant. J. Virol. 67:1993;2466-2474.
37. Novembre F. J., Saucier M. M., Hirsch V. M., Johnson P. R., McClure H. M. Viral genetic determinants in SIVsmmPBj pathogenesis. J. Med. Primatol. 23:1994;136-145.
38. Novembre F. J., Lewis M. G., Saucier M. M., Yalley-Ogunro J., Brennan T., McKinnon K., Bellah S., McClure H. M. Deletion of the nef gene abrogates the ability of SIVsmmPBj to induce acutely lethal disease in pigtail macaques. AIDS Res. Hum. Retroviruses. 12:1996;727-736.
39. Novembre F. J., Saucier M., Anderson D. C., Klumpp S. A., O'Neil S. P., Brown C. R. II, Hart C. E., Guenthner P. C., Swenson R. B., McClure H. M. Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1. J. Virol. 71:1997;4086-4091.
40. Ratner L., Niederman T. M. J. Nef. Curr. Top. Microbiol. Immunol. 193:1995;169-208.
41. Sawai E. T., Baur A. S., Peterlin B. M., Levy J. A., Cheng-Mayer C. A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity. J. Biol. Chem. 270:1995;15307-15314.
42. Sawai E. T., Kahn I. H., Montbrand P. M., Peterlin B. M., Cheng-Mayer C., Luciw P. A. Activation of PAK by HIV and SIV Nef: Importance for AIDS in rhesus macaques. Curr. Biol. 6:1996;1519-1527.
43. Schwartz O., Marechal V., Danos O., Heard J.-M. Human immunodeficiency virus type 1 nef increased the efficiency of reverse transcription in the infected cell. J. Virol. 69:1995;4053-4059.
44. Schwartz O., Marechal V., Le Gall S., Lemonnier F., Heard J. M. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nature Med. 2:1996;338-342.
45. Schwiebert R. S., Tao B., Fultz P. N. Loss of the SIVsmmPBj14 phenotype and nef genotype during long-term survival of macaques infected by mucosal routes. Virology. 230:1997;82-92.
46. Terwilliger E., Sodroski J. G., Rosen C. A., Haseltine W. A. Effects of mutations within the 3′ orf reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity. J. Virol. 60:1986;754-760.
47. Veazey, R. Demaria, M. Chalifoux, L. Shvetz, D. Rosenzweig, M. Lackner, A. 1997, CD4 Cell Depletion Occurs Rapidly and Preferentially in Gut-Associated Lymphoid Tissues (GALT) of SIV-Infected Macaques.
48. Wyand M. S., Manson K. H., Lackner A. A., Desrosiers R. C. Resistance of neonatal monkeys to live attenuated vaccine strains of simian immunodeficiency virus. Nat. Med. 3:1997;32-36.
49. Zack, P. M. Hall, W. C. Vogel, A. P. Elkins, W. R. Brown, C. R. Lewis, M. G. Jahrling, P. B. 1989, Pathology and Immunopathology of SIVsmm-PBj Associated Gastroenteritis in Macaques, 99.