Increased regional cerebral glucose metabolism and semantic memory performance in Alzheimer's disease: A pilot double blind transdermal nicotine positron emission tomography study

Neuropsychology Review

Volumn 6, Issue 2, 1996, Pages 61-79

  Parks, Randolph W ^a   Becker, Robert E ^a   Rippey, Robert F ^a   Gilbert, David G ^a   Matthews, Jane R ^a   Kabatay, Esperanza ^a   Young, Carter S ^b   Vohs, Cathy ^b   Danz, Valerie ^b   Keim, Patricia ^b   Collins, G Todd ^b   Zigler, Steven S ^b   Urycki, Paul G ^b  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Cholinergic stimulation; Positron emission tomography; Semantic memory; Transdermal nicotine; Verbal fluency

Indexed keywords

NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN METABOLISM; CASE REPORT; CHOLINERGIC STIMULATION; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; HUMAN; MALE; MEMORY; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; RANDOMIZED CONTROLLED TRIAL; SEMANTICS; TRANSDERMAL DRUG ADMINISTRATION; VERBAL BEHAVIOR;

ALZHEIMER DISEASE; DOUBLE-BLIND METHOD; GLUCOSE; HUMANS; MEMORY; NICOTINE;

EID: 0030478369     PISSN: 10407308     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01875368     Document Type: Article

References (35)

1. Albert, M. S., and Moss, M. B. (eds.). (1988). Geriatric Neuropsychology. Guilford Press, New York
2. Arneric, S. P., Sullivan, J. P., Decker, M. W., Brioni, J. D., Bannon, A. W., Clark, A., Donnelly-Roberts, D., Radek, R. J., Marsh, K. C., Kyncl, J., Williams, M., and Buccafusco, J. J. (1995). Potential treatment of Alzheimer Disease using cholinergic channel activators (ChCAs) with cognitive enhancement, anxiolytic-like, and cytoprotective properties. Alzheimer Disease and Associated Disorders 9 (Suppl. 2): 50-61.
3. Bayles, K. A., Salmon, D. P., Tomoeda, C. K., Jacobs, D., Caffrey, J. T., Kaszniak, A. W., and Troster, A. I. (1989). Semantic and letter category naming in Alzheimer's patients: A predictable difference. Developmental Neuropsychology 5: 335-347.
4. Becker, R. E., and Giacobini, E. (eds.). (1991). Cholinergic Basis for Alzheimer Therapy, Boston, Birkhäuser.
5. Benowitz, N., Porchet, and Jacob, P. (1990). Pharmacokinetics, metabolism, and pharmacodynamics of nicotine. In Wonnacottk, S., Russell, M., and Stolerman, I. (eds.), Nicotine Psychopharmacology, Oxford University Press, Oxford, pp. 112-151.
6. Benton, A. L. (1968). Differential behavioral effects in frontal lobe disease. Neuropsychologia 6: 53-60.
7. Boivin, M. J., Giordani, B., Berent, S. Amato, D. A., Lehtinen, S., Koeppe, R. A., Buchtel, H. A., Foster, N. L., and Kuhl, D. E. (1992). Verbal fluency and positron emission tomographic mapping of regional cerebral glucose metabolism. Cortex 28: 231-239.
8. Crockett, D. J., Bilsker, D., Hurwitz, T., and Kozak, J. (1986). Clinical utility of three measures of frontal lobe dysfunction in neuropsychiatrie samples. International Journal of Neuroscience 30: 241-248.
9. Duara, R., Grady, C., Haxby, J., Ingrav, D., Sokoloff, L., Margolin, R. A., Manning, R. G., Cutler, N. R., and Rapoport, S. I. (1984). Human brain glucose utilization and cognitive function in relation to age. Annals of Neurology 16: 702-713.
10. Duara, R., Gross-Glenn K., Barker, W. W., Chang, J. Y., Appicella, A., Loewenstein, D., and Boothe, T. (1987). Behavioral activation and the variability of cerebral glucose metabolic measurements. Journal of Cerebral Blood Flow and Metabolism 7: 266-271.
11. Duara, R., Loewenstein, D. A., and Barker, W. W. (1990). Utilization of behavioral activation paradigms for positron emission tomography studies in normal young and elderly subjects and in dementia. In Duara R. (ed.), Positron Emission Tomography in Dementia, John Wiley, New York, pp. 131-148.
12. Eberling, J. L., Jagust, W. J., Reed, B. R., and Baker, M. G. (1992), Reduced temporal lobe blood flow in Alzheimer's disease. Neurobiology of Aging 13: 483-491.
13. 3H) nicotine binding in human cerebral cortex: Comparison between Alzheimer's disease and the normal. Journal of Neurochemistry 47: 1948-1954.
14. Foster, N., Chase, T., Fedio, P., Patronas, N., Brooks, R., and DiChiro, G. (1983). Alzheimer's disease: Focal cortical changes shown by positron emission tomography. Neurology 33: 961-965.
15. 18F] fluorodeoxyglucose. Journal of Computer Assisted Tomography 7: 590-598.
16. Friston, K. J., Frith, C. D., Liddle, P. F., and Frackowiak, R. S. (1991). Investigating a network model of word generation with positron emission tomography. Proceedings of the Royal Society of London 244: 101-106.
17. Frith, C. D., Friston, K. J., Liddle, P. F., and Frackowiak, R. S. (1991). Willed action and the prefrontal cortex in man: A study with PET. Proceedings of the Royal Society of London 244: 241-246.
18. Giacobini, E. (1990). Cholinergic receptors in human brain: Effects of aging and Alzheimer disease. Journal of Neuroscience Research 27: 548-560.
19. Giacobini, E. (1991). Nicotinic cholinergic receptors in human brain: Effects of aging and Alzheimer. In Timiras, P. S. (ed.), Plasticity and Regeneration of the Nervous System, Plenum Press, New York, pp. 303-315.
20. Haxby, J. (1984). Neuropsychology and cerebral metabolism in dementia. Annals of Internal Medicine 101: 362-364.
21. Haxby, J. V., Grady, C. L., Duara, R., Robertson-Tchabo, E., Koziarz, B., Cutler, N. R., and Rapoport, S. I. (1987). Relations among age, visual memory, and testing cerebral metabolism in 40 healthy men. Brain and Cognition 5: 412-427.
22. Hindmarch, I., Kerr, J., and Sherwood, N. (1990). Effects of nicotine gum on psychomotor performance in smokers and non-smokers. Psychopharmacology 100: 535-541.
23. Horner, M. D. (1990). Psychobiological evidence for the distinction between episodic and semantic memory. Neuropsychology Review 1: 281-321.
24. Horwitz, B, Grady, C., Haxby, J., Schapiro, M., and Rapoport, S. (1992). Functional associations among human posterior extrastriate brain regions during object and spatial vision. Journal of Cognitive Neuroscience 4: 311-322.
25. Jones, G., Sahakian, B., Levy, R., Warburton, D., and Gray, J. (1992). Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease. Psychopharmacology 108: 485-494.
26. Kellear, K., and Wonnacott, S. (1990). Nicotinic cholinergic receptors in Alzheimer's disease. In Wonnacott, S., Russell, M., and Stolerman, I. (eds.), Nicotine Psychopharmacology, Oxford University Press, Oxford, pp. 341-373.
27. Levin, E., and Rosecrans, J. (1994). Promise of Nicotinic-based therapeutic treatments. Drug Development Research 31: 1-2.
28. Levine, D. S., and Parks, R. W. (1992). Frontal lesion effects on verbal fluency in a network model. Proceedings of the International Conference on Neural Networks (Vol. 2). Baltimore, MD, ICNN, pp. 39-44.
29. Levine, D. S., and Parks, R. W. (1993). A neural-network model of frontal-lesion effects on verbal fluency. Journal of Clinical and Experimental Neurospychology 15: 70.
30. Levine, D. S., Parks, R. W., and Prueitt, P. S. (1993). Methodological and theoretical issues in neural network models of frontal cognitive functions. International Journal of Neuroscience 72: 209-233.
31. London, E. D., Ball, M. J., and Waller, S. B. (1989). Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia. Neurochemical Research 14: 745-750.
32. McGeer, P. L., Kamo, H., Harrop, R., Li, D. K., Tuokko, H., McGeer, E. G., Adam, J. A., Ammann, W., Beattie, B. L., Calne, D. B., Martin, W. R., Pate, B. D., Rogers, J. G., Ruth, T. J., Sayre, C. I., and Stoessl, A. J. (1986). Positron emission tomography in patients with clinically diagnosed Alzheimer's disease. Canadian Medical Association Journal 134: 597-607.
33. McKhann, F., Drachman, D., Folstein, M., Katzman, R., Price, D., and Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 934-944.
34. Medical Economics Company. (1995). Physicians Desk Reference. (47th ed.). Montvale, NJ: Author.
35. Miceli, G., Caltagirone, C., Gainotti, G., Masullo, C., and Silveri, M. C. (1981). Neuropsychological correlates of localized cerebral lesions in non-aphasic brain-damaged patients. Journal of Clinical Neuropsychology 3: 56-63.