Angioprotective action of calcium dobesilate against reactive oxygen species-induced capillary permeability in the rat

European Journal of Pharmacology

Volumn 358, Issue 3, 1998, Pages 213-220

  Brunet, John ^a   Farine, Jean Claude ^b   Garay, Ricardo P ^a   Hannaert, Patrick ^a  

^a INSERM   (France)

^b OM Laboratories   (Switzerland)

Author keywords

Antioxidant; Calcium dobesilate; Free radical; Vascular permeability

Indexed keywords

DOBESILATE CALCIUM; EVANS BLUE; HEMOSTATIC AGENT; PHENAZINE METHOSULFATE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; RUTOSIDE; SUPEROXIDE DISMUTASE; XANTHINE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAPILLARY PERMEABILITY; CONTROLLED STUDY; DOSE RESPONSE; EXTRAVASATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PERITONEAL CAVITY; PRIORITY JOURNAL; RAT;

EID: 0032500892     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00604-9     Document Type: Article

References (38)

1. Afanas'ev, I.B., Ostrachovitch, E.A., Abramova, L.G., Kirkina, N.E., 1995. Different antioxidant activities of bioflavonoid rutin in normal and iron-overloading rats. Biochem. Pharmacol. 50 (1995), 627-635.
2. Baynes, J.W., 1991. Role of oxidative stress in development of complications in diabetes. Diabetes 40, 405-412.
3. Beckman, J.S., Koppenol, W.H., 1996. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am. J. Physiol. 271, C1424-C1437.
4. Benakis, A., Glasson, B., Bouvier, C., Ritschard, J., Krahenbuhl, B., Jung, A., Hachen, H., 1974. Métabolisme and pharmacocinétique du dobésilate de calcium chez l'homme. Thérapie 29, 211-219.
5. Beyer, J., Meissner, H.J., Cordes, U., 1980. Calcium dobesilate reduces microvascular permeability to plasma proteins in diabetes mellitus. Med. Wochenschr. 105, 1604-1608.
6. Bijsterveld, J., Janssen, P.T., 1981. The effect of calcium dobesilate on albumin leakage of the conjunctival vessels. Curr. Eye Res. 1, 425-430.
7. Brenner, H., Burkart, V., Rothe, H., Kolb, H., 1993. Oxygen radicals production is increased in macrophages from diabetes-prone BB rats. Autoimmunity 15, 93.
8. Brunet, J., Garay, R., Hannaert, P., 1994. Calcium dobesilate has oxygen free radical scavenger properties. Can. J. Physiol. Pharmacol. 72 (S1), 596.
9. Brunet, J., Farine, J.C., Garay, R., Hannaert, P., 1998. In vitro antioxidant properties of calcium dobesilate. Fundam. Clin. Pharmacol. 12, 205-212.
10. Casley-Smith, J.R., Curri, S., Foldi, M., 1993. Topical treatment of acute hindlimb lymphedema of the rat using a troxerutin-phosphatidylcholine complex in liposomal-like microdispersion. Lymphology 26, 25-27.
11. Chen, Y.T., Zheng, R.L., Jia, Z.J., Ju, Y., 1990. Flavonoids as superoxide scavengers and antioxidants. Free Radic. Biol. Med. 9, 19-21.
12. Del Maestro, R.F., Bjork, J., Arfors, K.E., 1981a. Increase in microvascular permeability induced by enzymatically generated free radicals: I. In vivo study. Microvasc. Res. 22, 239-254.
13. Del Maestro, R.F., Bjork, J., Arfors, K.E., 1981b. Increase in microvascular permeability induced by enzymatically generated free radicals: II. Role of superoxide anion radical, hydrogen peroxide and hydroxyl radical. Microvasc. Res. 22, 255-270.
14. Doly, M., Droy-Lefaix, M.T., 1992. Lipid peroxidation in the pathology of the retina. Free radicals in the brain aging. In: Packer, L., Prilipko, L., Christen, Y. (Eds.), Neurological and Mental Disorders. Springer-Verlag, Berlin, pp. 123-139.
15. Grinberg, L.N., Rachmilewitz, E.A., Newmark, H., 1994. Protective effects of rutin against hemoglobin oxidation. Biochem. Pharmacol. 48, 643-649.
16. Hachen, H., Hachen, F.I.C.A., Lorenz, P., 1982. Etude clinique and pléthysmographique en double-aveugle du Dobésilate de Calcium chez des patientes atteintes de troubles microcirculatoires périphériques. Angiologie 33, 480-487.
17. Halliwell, B., 1993. The role of oxygen radicals in human disease with particular reference to the vascular system. Haemostasis 23, 118-126.
18. Halliwell, B., 1995. Antioxidant characterization. Methodology and mechanism. Biochem. Pharmacol. 49, 1341-1348.
19. Hasslacher, C., Kopischke, H., Bürklin, E., 1981. Hemmung der gesteigerten Synthese kapillärer Basalmembran diabetischer Ratten in vivo. Vasa 10, 148-150.
20. Leite, E., Mota, M., Faria de Abreu, J., Cunha-Vaz, J., 1990. Effect of calcium dobesilate on the blood-retinal barrier in early diabetic retinopathy. Int. Ophthalmol. 14, 81-88.
21. Maridonneau-Parini, I., Braquet, P., Garay, R.P., 1986. Heterogeneous effects of flavonoids on K loss and lipid peroxydation induced by oxygen-free radicals in human red cells. Pharm. Res. Commun. 18, 61-72.
22. Marmo, E., 1987. Calcium dobesilate in medical treatment: experimental and clinical aspects. Eur. Rev. Med. Pharmacol. Sci. 9, 1-60.
23. Michal, M., Giessinger, N., 1985. Effect of calcium dobesilate and its interaction with aspirin on thrombus formation in vivo. Thromb. Res. 40, 215-226.
24. Michal, M., Gotti, C., 1988. Effect of calcium dobesilate on platelet function. Thromb. Res. 51, 593-605.
25. Nagakura, T., Ebisawa, M., Reason, D.C., Iikura, Y., 1990. Chemical mediators in hypersensitivity reactions. Acta Paediatr. Jpn 32, 209-215.
26. Nelson, C., Wei, E., Povlishock, J., Kontos, H., Moskowitz, M., 1992. Oxygen radicals in cerebral ischemia. Am. J. Physiol. 263, H1356-H1362.
27. Oliver, J.A., 1992. Endothelium-derived relaxing factor contributes to the regulation of endothelial permeability. J. Cell. Physiol. 151, 506-511.
28. Rehn, D., Nocker, W., Diebschlag, W., Golden, G., 1993. Time course of the anti-oedematous effect of different dose regimens of O-(beta-hy-droxyethyl) rutosides in healthy volunteers. Arzneimittelforschung 43, 335-338.
29. Renton, S., Leon, M., Belcaro, G., Nicolaides, A.N., 1994. The effect of hydroxyethylrutosides on capillary filtration in moderate venous hypertension: a double blind study. Int. Angiol. 13, 259-262.
30. Ruiz, E., Lorente, R., Tejerina, T., 1997. Effects of calcium dobesilate on the synthesis of endothelium-dependent relaxing factors in rabbit isolated aorta. Br. J. Pharmacol. 121, 711-716.
31. Schmitt, A., Salvayre, R., Delchambre, J., Nègre-Salvayre, A., 1995. Prevention by alpha-tocopherol and rutin of glutathione and ATP-depletion induced by oxidized LDL in cultured endothelial cells. Br. J. Pharmacol. 116, 1985-1990.
32. Siflinger-Birnboim, A., Bode, D.C., Malik, A.B., 1993. Adenosine 3', 5'-cyclic monophosphate attenuates neutrophil-mediated increase in endothelial permeability. Am. J. Physiol. 264, H370-H375.
33. Smith, J.K., Carden, D.L., Korthuis, R.J., 1991. Activated neutrophils increase microvascular permeability in skeletal muscle: role of xanthine oxidase. J. Appl. Physiol. 70, 2003-2009.
34. Suttorp, N., Hippenstiel, S., Fuhrmann, M., Krüll, M., Podzuweit, T., 1996. Role of nitric oxide and phosphodiesterase isoenzyme II for reduction of endothelial hyperpermeability. Am. J. Physiol. 270, C778-C785.
35. Tate, R., Vanbenthuyse, K., Shasby, M., McMurtry, I., Repine, J., 1982. Oxygen-radical-mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs. Am. Rev. Respir. Dis. 126, 802-806.
36. Vojnikovic, B., 1991. Doxium® (calcium dobesilate) reduces blood hyperviscosity and intra-ocular pressure in patients with diabetic retinopathy and glaucoma. Ophthalmol. Res. 23, 12-20.
37. Widmer, L., Biland, L., Barras, J.P., 1990. Doxium® 500 dans le traitement de l'insuffisance veineuse chronique: étude multicentre en double aveugle contre placebo. Int. Angiol. 9, 105-110.
38. Yaqoob, M., Ptak, A., McClelland, P., Stevenson, A., Mason, H., White, M., Bell, G., 1993. Relationship between markers of endothelial dysfunction, oxidative injury and tubular damage in patients with insulin-dependent diabetes mellitus. Clin. Sci. 85, 557-562.