Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse

Neuroscience Letters

Volumn 255, Issue 1, 1998, Pages 57-60

  Kitamura, Yoshihisa ^a   Ota, Takashi ^a   Matsuoka, Yasuji ^a   Okazaki, Mitsuhiro ^a   Kakimura, Jun Ichi ^a   Tooyama, Ikuo ^b   Kimura, Hiroshi ^b   Shimohama, Shun ^c   Gebicke Haerter, Peter J ^d   Nomura, Yasuyuki ^e   Taniguchi, Takashi ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b Inst Molec Neurbio   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d UNIVERSITY OF FREIBURG   (Germany)

^e HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Astrocytes; Hippocampal CA3; Kainic acid; Microglia; Neuronal loss; p53 deficient mouse; Phosphorylated c Jun

Indexed keywords

KAINIC ACID; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTOSIS; CELL DEATH; CYTOTOXICITY; DNA DAMAGE; GENE TARGETING; GLIA CELL; HIPPOCAMPUS; MOUSE; NERVE DEGENERATION; NONHUMAN; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; PYRAMIDAL NERVE CELL;

ANIMALS; BIOLOGICAL TRANSPORT; CELL NUCLEUS; CELL SURVIVAL; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; KAINIC ACID; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, KNOCKOUT; NEUROGLIA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-JUN; PYRAMIDAL CELLS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032500782     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00714-9     Document Type: Article

References (15)

1. Andersson P.-B., Perry V.H., Gordon S. The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration. Neuroscience. 42:1991;201-214.
2. Chen Z.L., Strickland S. Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell. 91:1997;917-925.
3. Franklin, K.B.J. and Paxinos, G., The Mouse Brain in Stereotaxic Coordinates, Academic Press, San Diego, CA, 1997.
4. Gerlai R. Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci. 19:1996;177-181.
5. Kitamura, Y., Ota, T., Matsuoka, Y., Tooyama, I., Kimura, H., Shimohama, S., Nomura, Y., Gebicke-Haerter, P.J. and Taniguchi, T., Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells, Glia, (1998) in press.
6. Kitamura Y., Shimohama S., Kamoshima W., Matsuoka Y., Nomura Y., Taniguchi T. Changes of p53 in the brains of patients with Alzheimer's disease. Biochem. Biophys. Res. Commun. 232:1997;418-421.
7. Ko L.J., Prives C. p53: puzzle and paradigm. Genes Dev. 10:1996;1054-1072.
8. MacGregor D.G., Higgins M.J., Jones P.A., Maxwell W.L., Watson M.W., Graham D.I., Stone T.W. Ascorbate attenuates the systemic kainate-induced neurotoxicity in the rat hippocampus. Brain Res. 727:1996;133-144.
9. Morrison R.S., Wenzel H.J., Kinoshita Y., Robbins C.A., Donehower L.A., Schwartzkroin P.A. Loss of the p53 tumor suppressor gene products neurons from kainate-induced cell death. J. Neurosci. 16:1996;1337-1345.
10. Nadler J.V., Perry B.W., Gentry C., Cotman C.W. Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid. J. Comp. Neurol. 192:1980;333-359.
11. Schauwecker P.E., Steward O. Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches. Proc. Natl. Acad. Sci. USA. 94:1997;4103-4108.
12. Tsukada T., Tomooka Y., Takai S., Ueda Y., Nishikawa S., Yagi T., Tokunaga T., Takeda N., Suda Y., Abe S., Matsuo I., Ikawa Y., Aizawa S. Enhanced proliferative potential in culture of cells from p53-deficient mice. Oncogene. 8:1993;3313-3322.
13. Xiang H., Hochman D.W., Saya H., Fujiwara T., Schwartzkroin P.A., Morrison R.S. Evidence for p53-mediated modulation of neuronal viability. J. Neurosci. 16:1996;6753-6765.
14. Yang D.D., Kuan C.-Y., Whitmarsh A.J., Rincón M., Zheng T.S., Davis R.J., Rakic P., Flavell R.A. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature. 389:1997;865-870.
15. Yang G., Kitagawa K., Matsushita K., Mabuchi T., Yagita Y., Yanagihara T., Matsumoto M. C57BL/6 strain is most susceptible to cerebral ischemia following bilateral common carotid occlusion among seven mouse strains: selective neuronal death in the murine transient forebrain ischemia. Brain Res. 752:1997;209-218.