Construction of a family of Cys2His2 zinc binding sites in the hydrophobic core of thioredoxin by structure-based design

Biochemistry

Volumn 37, Issue 23, 1998, Pages 8269-8277

  Wisz, Michael S ^a   Garrett, Christopher Z ^a   Hellinga, Homme W ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THIOREDOXIN; COBALT; CYSTEINE; HISTIDINE; ZINC;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; TOXIN ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINO ACID SEQUENCE; BINDING SITES; CIRCULAR DICHROISM; COBALT; CYSTEINE; HISTIDINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOREDOXIN; ZINC;

EID: 0032499535     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980718f     Document Type: Article

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