Gender-related differences in drug response; Hormone-dependent pharmacodynamic differences rarely studied;Män och kvinnor reagerar olika på läkemedel: Hormonellt betingade farmakodynamiska skillnader föga studerade

Lakartidningen

Volumn , Issue 28-29, 1998, Pages 3177-3182

  Vinge, Ellen ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG; DRUG RECEPTOR; SEX HORMONE;

ANIMAL; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG APPROVAL; DRUG EFFECT; FEMALE; MALE; METABOLISM; PRACTICE GUIDELINE; PREGNANCY; RAT; REVIEW; SEX DIFFERENCE; SEXUAL DEVELOPMENT; SWEDEN; UNITED STATES;

ANIMALS; CLINICAL TRIALS; DRUG APPROVAL; FEMALE; GONADAL STEROID HORMONES; GUIDELINES; MALE; PHARMACEUTICAL PREPARATIONS; PREGNANCY; RATS; RECEPTORS, DRUG; SEX CHARACTERISTICS; SEX FACTORS; SWEDEN; UNITED STATES;

EID: 0032496784     PISSN: 00237205     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Department of Health and Human Services: Food and Drug Administration. Guideline for the study and evaluation of gender differences in the clinical evaluation of drugs; Notice. Federal Register 1993; 58: 39406-16.
2. Kassell NF, Haley EC, Aperson-Hansen C, Alves WM. A randomized, doubleblind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: a cooperative study in Europe/Australia/New Zealand. J Neurosurg 1996; 84: 221-8.
3. Kloner RA, Sowers JR, DiBona GF, Gaffney M, Wein M for the Amlodipine Cardiovascular Community Trial Study Group. Sex- and age-related antihypertensive effects of amlodipine. Am J Cardiol 1996; 77: 713-22.
4. Packer M, O'Connor CM, Ghali JK, Pressler ML, Carson PE, Belkin RN et al for the Prospective Randomized Amlodipine Survival Evaluation Study Group. N Engl J Med 1996; 335: 1107-14.
5. Yonkers KA, Kando JC, Cole JO, Blumenthal S. Gender differences in pharmacokinetics and pharmacodynamics of pshychotropic medication. Am J Psychiatry 1992; 149: 587-95.
6. Makkar RR, Fromm BS, Steinman RT, Meissner MD, Lehmann MH. Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs. JAMA 1993; 270: 2590-7.
7. Lehmann MH, Hardy S, Archibald D, Quart B, MacNeil DJ. Sex difference in risk of torsade de pointes with d,1-sotalol. Circulation 1996; 94: 2534-41.
8. Lipshultz SE, Lipsitz SR, Mone SM, Goorin AM, Sallan SE, Sanders SP et al. Female sex and higher drug dose as risk factors for late cardiotoxic effects of doxorubicin therapy for childhood cancer. N Engl J Med 1995; 332: 1738-43.
9. Harris RZ, Benet LZ, Schwartz JB. Gender effects in pharmacokinetics and pharmacodynamics. Drugs 1995; 50: 222-39.
10. Teichmann AT. Influence or oral contraceptives on drug therapy. Am J Obstet Gynecol 1990; 163: 2208-13.
11. Stallone JN, Crofton JT, Share L. Sexual dimorphism in vasopressin-induced contraction of rat aorta. Am J Physiol 1991; 260: H 453-8.
12. Stallone JN. Role of endothelium in sexual dimorphism in vasopressin-induced contraction of rat aorta. Am J Physiol 1993; 265: H2073-80.
13. Kauser K, Rubanyi GM. Gender difference in bioassayable endothelium-derived nitric oxide from isolated rat aortae. Am J Physiol 1994; 267: H2311-7.
14. Maddox YT, Falcon JG, Ridinger M, Cunard CM, Ramwell PW. Endotheliumdependent gender differences in the response of the rat aorta. J Pharmacol Exp Ther 1987; 240: 392-5.
15. St-Louis J, Parent A, Larivière R, Schriffrin EL. Vasopressin responses and receptors in the mesenteric vasculature of estrogen-treated rats. Am J Physiol 1986; 251: H885-9.
16. Freedman RR, Sabharwal SC, Desai N. Sex differences in peripheral vascular adrenergic receptors. Circ Res 1987; 61: 581-5.
17. Chowienczyk PJ, Watts GF, Cockcroft JR, Brett SE, Ritter JM. Sex differences in endothelial function in normal and hypercholesterolaemic subjects. Lancet 1994; 344: 305-6.
18. Kando JC, Yonkers KA, Cole JO. Gender as a risk factor for adverse events to medications. Drugs 1995; 50: 1-6.
19. Larsson B, Andersson KE, Batra S, Mattiasson A, Sjögren C. Effects of estradiol on norepinephrine-induced contraction, alpha adrenoceptor number and norepnephrine content in the female rabbit urethra. J Pharmacol Exp Ther 1984; 229: 557-63.
20. Burman P, Johansson AG, Siegbahn A, Vessby B, Karlsson FA. Growth hormone (GH)-deficient men are more responsive to GH replacement therapy than women. J Clin Endocrinol Metab 1997; 82: 550-5.