Development of fusimotor innervation correlates with group Ia afferents but is independent of neurotrophin-3

Developmental Brain Research

Volumn 111, Issue 2, 1998, Pages 295-300

  Ringstedt, Thomas ^a   Copray, Sjef ^b   Walro, Jon ^c   Kucera, Jan ^d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c Northeastern Ohio Medical University   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fusimotor innervation; Growth factor; Muscle spindle; Neurotrophin 3; Proprioception; Transgenic mice

Indexed keywords

NEUROTROPHIN 3;

AFFERENT NERVE GROUP 1; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; GAMMA NERVE FIBER; HINDLIMB; INNERVATION; MASTICATORY MUSCLE; MOUSE; MUSCLE SPINDLE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; TRIGEMINAL NUCLEUS; VENTRAL ROOT;

ANIMALS; ATAXIA; JAW; MASTICATION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MOTOR NEURONS; MUSCLE SPINDLES; MUSCLE, SKELETAL; NERVE FIBERS, MYELINATED; NERVE GROWTH FACTORS; NEURONS, AFFERENT; NEUROTROPHIN 3; PROPRIOCEPTION;

ANIMALIA; MUS MUSCULUS;

EID: 0032495112     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(98)00146-1     Document Type: Article

References (15)

1. D. Barker, The morphology of muscle receptors, in: D. Barker, C. Hunt, A. McIntyre, (Eds.). Handbook of Sensory Physiology, vol. 3/2, Springer-Verlag, New York, 1974, pp. 2-190.
2. Copray J.C., Brouwer N. Selective expression of neurotrophin-3 messenger RNA in muscle spindles in the rat. Neuroscience. 63:1994;1125-1135.
3. Ernfors P., Lee K.-F., Kucera J., Jaenisch R. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell. 77:1994;503-512.
4. Ernfors P., Merlio J.-P., Persson H. Cells expressing mRNA for neurotrophins and their receptors during embryonic rat development. Eur. J. Neurosci. 4:1992;1140-1158.
5. Fariñas I., Jones K.R., Backus C., Wang X.-Y., Reichhardt L. Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. Nature. 369:1994;658-661.
6. Klein R., Silos-Santiago I., Smeyne R.J., Lira S., Brambilla R., Bryant S., Zhang L., Snider W., Barbacid M. Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movements. Nature. 368:1994;249-251.
7. Koliatsos V.E., Clatterbuck R.E., Winslow J.W., Cayouette M., Price D. Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo. Neuron. 10:1993;359-367.
8. Kucera J., Ernfors P., Walro J., Jaenisch R. Reduction in the number of spinal motor neurons in neurotrophin-3-deficient mice. Neuroscience. 69:1995;321-330.
9. Kucera J., Fan G., Jaenisch R., Linnarsson S., Enfors P. Dependance of developing group Ia afferents on neurotrophin-3. J. Comp. Neurol. 363:1995;307-320.
10. Kucera J., Fan G., Walro J., Copray S., Tessarollo L., Jaenisch R. Neurotrophin-3 and trkC in muscle are non-essential for the development of mouse muscle spindles. NeuroReport. 9:1998;905-909.
11. Nosrat C.A., Tomac A., Lindqvist E., Lindskog S., Humpel C., Stromberg I., Ebendal T., Hoffer B.J., Olson L. Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system. Cell Tiss. Res. 286:1996;191-207.
12. Ringstedt T., Kucera J., Lendahl U., Ernfors P., Ibáñez C.F. Limb proprioceptive deficits without neuronal loss in transgenic mice overexpressing neurotrophin-3 in the developing nervous system. Develop. 124:1997;2603-2613.
13. Schecterson L.C., Bothwell M. Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons. Neuron. 9:1992;449-463.
14. Wright D.E., Zhou L., Kucera J., Snider W.D. Introduction of a neurotrophin-3 transgene into muscle selectively rescues proprioceptive neurons in mice lacking endogenous neurotrophin-3. Neuron. 19:1997;503-517.
15. Zelena J. The morphogenetic influence of innervation on the ontogenetic development of muscle-spindles. J. Embryol. Exp. Morphol. 5:1957;283-292.