The first selective and efficient transport of imide-containing nucleosides and nucleotides by lipophilic cyclen-zinc(II) complexes (cyclen = 1,4,7,10-tetraazacyclododecane)

Journal of the American Chemical Society

Volumn 120, Issue 39, 1998, Pages 10018-10026

  Aoki, Shin ^a   Honda, Yusuke ^a   Kimura, Eiichi ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 HEXADECYL 1,4,7,10 TETRAAZACYCLODODECANE ZINC II COMPLEX; ANTIVIRUS AGENT; NUCLEOSIDE DERIVATIVE; TEGAFUR; THYMIDINE PHOSPHATE; THYMIDINE TRIPHOSPHATE; UNCLASSIFIED DRUG; ZIDOVUDINE; ZINC COMPLEX; ZINC II COMPLEX;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING KINETICS; CALORIMETRY; COMPLEX FORMATION; EXTRACTION; NONHUMAN; NUCLEOTIDE METABOLISM; QUANTITATIVE DIAGNOSIS;

EID: 0032494386     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9810888     Document Type: Article

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28. -1), respectively, indicating that transfer of AZT by 2e is ca. 4 times faster than the control.
29. The preliminary experiment showed that AZT uptake into human fibroblast cell, TIG-3, was enhanced by 2e (unpublished results by S. Aoki, K. Anno, T. Ide, and E. Kimura).