Malaria: Dissecting chloroquine resistance

Current Biology

Volumn 8, Issue 10, 1998, Pages

  Ridley, Robert G ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; PLASMODIUM FALCIPARUM;

EID: 0032493040     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0960-9822(98)70218-0     Document Type: Article

References (14)

1. Plowe CV, Wellems TE: Molecular approaches to the spreading of drug resistant malaria. In Antimicrobial Resistance: A Crisis In Health Care. Edited by Jungkind DL. New York: Plenum Press; 1995:197-209
2. Su X-z, Kirkman LA, Fujoka H, Wellems TE: Complex polymorphisms in a 330 kDa protein are linked to chloroquine-resistant P. flaciparum in Southeast Asia and Africa. Cell 1997, 91:593-603.
3. Slater AFG: Chloroquine: mechanism of drug action and resistance in Plasmodium falciparum. Pharmacol Ther 1993, 57:203-255
4. Egan TJ, Ross DC, Adams PA: The mechanism of action of quinolines and related anti-malarial drugs. S Afr J Sci 1996, 92:11-14.
5. Ridley RG, Dorn A, Vippagunta SR, Vennerstrom JL: Haematin (haem) polymerisation and its inhibition by quinoline antimalarials. Ann Trop Med Parasitol 1997, 91:559-566.
6. Foley M, Tilley L: Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents. Pharmacol Ther 1998, in press.
7. Bray PG, Ward SA: A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline in Plasmodium falciparum. Pharmacol Ther 1998, 77:1-28.
8. Olliaro PL, Goldberg DE: The plasmodium digestive vacuole: metabolic headquarters and choice drug target. Parasitol Today 1995, 11:294-297.
9. Moon RP, Tyas L, Certa U, Rupp K, Bur D, Jaquet C, Matile H, Lötscher H, Grüninger-Leitch F, Kay J, et al.: Expression and characterisation of plasmepsin I from Plasmodium falciparum. Eur J Biochem 1997, 244:552-560.
10. Bray PG, Mungthin M, Ridley RG, Ward SA: Access to haematin: the basis of chloroquine resistance. Mol Pharmacol, in press.
11. Ridley RG, Hudson AT: Quinoline antimalarials. Exp Opin Ther Patents 1998, 8:121-136.
12. + exchanger determines chloroquine uptake in Plasmodium falciparum. J Cell Biol 1998, 140:2645-2654.
13. Wellems TE, Panton LA, Gluzman IY, do Rosario VE, Geadz RW, Walker-Jonah A, Krogstad DJ: Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross. Nature 1990, 345:253-255.
14. + exchanger of Plasmodium falciparum? Cell 1998, 92:601-602.