Use of soybean oil and ammonium sulfate additions to optimize secondary metabolite production

Biotechnology and Bioengineering

Volumn 60, Issue 5, 1998, Pages 580-588

  Junker, B ^a   Mann, Z ^a   Gailliot, P ^a   Byrne, K ^a   Wilson, J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Ammonium sulfate; Homologs; Lipase; Secondary metabolite production; Soybean oil; Streptomyces

Indexed keywords

AMMONIUM COMPOUNDS; BACTERIA; CATALYST ACTIVITY; COMPOSITION EFFECTS; ENZYMES; METABOLITES; PH; VEGETABLE OILS;

AMMONIUM SULFATE; SECONDARY METABOLITE PRODUCTION; SOYBEAN OIL;

FERMENTATION;

AMMONIUM SULFATE; SOYBEAN OIL;

ARTICLE; BIOTECHNOLOGY; DIET SUPPLEMENTATION; FERMENTATION; NONHUMAN; SEQUENCE HOMOLOGY; STREPTOMYCES HYGROSCOPICUS;

AMMONIUM SULFATE; BIOTECHNOLOGY; CARBON; CULTURE MEDIA; FERMENTATION; HYDROGEN-ION CONCENTRATION; LIPASE; NITROGEN; OXYGEN; QUATERNARY AMMONIUM COMPOUNDS; SOYBEAN OIL; STREPTOMYCES; VALINE;

EID: 0032488358     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19981205)60:5<580::AID-BIT8>3.0.CO;2-D     Document Type: Article

References (22)

1. Boeck, L. D., Favret, M. E., Wetzel, R. W. 1992. Biosynthesis of thiopeptide antibiotic A10255 in stirred reactors using a chemically defined medium supplemented with continuous nutrient feeds. J. Antibiotics 45(8): 1278-85.
2. Brana, A. F., Demain, A. L. 1988. Nitrogen control of antibiotic biosynthesis in actinomycetes, pp. 99-119. In S. Sanchez-Esquivel (ed.), Nitrogen source control of microbial processes. CRC Press, Boca Raton, FL.
3. Cavanagh, M. F., Ison, A. P., Lilly, M. D., Carleysmith, S. W., Edwards, J. 1994. The utilization of lipids during Streptomycete fermentations, Vol. 1, pp. 226-228. IChemE Res. Event, Two-Day Symp. Institute of Chemical Engineering, Rugby, UK.
4. David, L., Loutheiller, H., Bauchart, D., Auboiron, S., Asselineau, J. 1992. Effects of exogenous methyl oleate on the biosynthesis of nigericin, a polyether carboxylic antibiotic, by Streptomyces hygroscopicus NRRL B-1865.
5. Holt, T. G., Chang, C., Laurent-Winter, C., Murakami, T., Garrels, J. I., Davies, J. E., Thompson, C. J. 1992. Global changes in gene expression related to antibiotic synthesis in Streptomyces hygroscopicus. Molec. Microbiol. 6(8): 969-980.
6. Janecek, J., Tichy, P., Spizek, J., Vanek, Z. 1997. Constitution of the metabolic type of Streptomyces during the first hours of cultivation. Folia Microbiol. 42(2): 75-96.
7. Junker, B. H., Reddy, J., Olewinski, R., Gailliot, P., Byrne, K., Gbewonyo, K., 1998. Secondary metabolite scale-up to minimize homolog impurity levels. Biotechnol. Bioeng., in press.
8. Kim, S. Y., Oh, D. K., Lee, K. H., Kim, J. H., 1997. Effect of soybean oil and glucose on sophorose lipid fermentation by Torulopsis bombicola in continuous culture. Appl. Microbiol. Biotechnol. 48: 23-26.
9. King, R. 1997. A structured mathematical model for a class of organisms: I. Development of a model for Streptomyces tendae and application of model-based control. J. Biotechnol. 52: 219-234.
10. King, R., Budenbender, Ch. 1997. A structured mathematical model for a class of organisms: II. Application of the model to other strains. J. Biotechnol. 52: 235-244.
11. Laakel, M., Lebrihi, A., Khaoua, S., Schneider, F., Lefebvre, G., Germain, P. 1994. Relationship between valine, fatty acids, and spiramycin biosynthesis in Streptomyces ambofaciens. Can. J. Microbiol., 40: 672-676.
12. Lebrihi, A., Lamsaif, D., Lefebvre, G., Germain, P. 1992. Effect of ammonium ions on spiramycin biosynthesis in Streptomyces ambofaciens. Appl. Microbiol. Biotechnol. 37: 382-387.
13. Lee, M. S., Kojima, I., Demain, A. L. 1997. Effect of nitrogen source on biosynthesis of rapamycin by Streptomyces hygroscopicus. J. Ind. Micro. Biotechnol. 19: 83-86.
14. Mouslim, J., David, L., Petel, G., Gentraud, M. 1993. Effect of exogenous methyl oleate on the time course of some parameters of Streptomyces hygroscopicus NRRL B-1865 culture. Appl. Microbiol. Biotechnol. 39: 585-588.
15. Mouslin, J., El Haloui, N-E., David, L. 1997. Influence of fatty acids and detergents on polyether antibiotic production by Streptomyces hygroscopicus NRRL B-1865. Can. J. Microbiol. 43: 879-883.
16. Okada, S., Iwamatu, S. 1997. Scale up production of milbemycin by Streptomyces hygroscopicus subsp. aurelacrimosus with control of internal pressure, temperature, aeration and agitation. J. Chem. Technol. Biotechnol. 70: 179-187.
17. Park, Y. S., Momose, I., Tsunoda, K., Okabe, M. 1994. Enhancement of cephamycin C production using soybean oil as the sole carbon source. Appl. Microbiol. Biotechnol. 40: 773-779.
18. Reynolds, K. A., Demain, A. L. 1997. Rapamycin, FK506, and ascomycin-related compounds. Chapter 17, pp. 497-520. In: William Strohl (ed), Biotechnology of antibiotics. Marcel Dekker, New York.
19. Stryer, L. 1981. Biochemistry, p. 399. W.H. Freeman and Co., San Francisco, CA.
20. Sun, W.-J., Salmon, P., Wilson, J., Connors, N. Crotonic acid-directed biosynthesis of the immunosuppressants produced by Streptomyces hygroscopicus var. ascomyceticus. J. Ferment. Bioeng. 86(3), in press.
21. Vucetic, J., Karadzic, I., Gojgic-Cvijovic, G., Radovanovic, E., 1994. Improving hexaene H-85 production by Streptomyces hygroscopicus. J. Serb. Chem. Soc. 59(12): 573-578.
22. Yoon, Y. J., Choi, C. Y. 1997. Nutrient effects on FK-506, a new immunosuppressant, production by Streptomyces sp. in a defined medium. J. Ferment. Bioeng. 83(6): 599-603.