C-attached aminoalkylindoles: Potent cannabinoid mimetics

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 1, 1996, Pages 17-22

  D'Ambra, Thomas E ^a   Eissenstat, Michael A ^a,c   Abt, Jeffrey ^a   Ackerman, James H ^a   Bacon, Edward R ^a   Bell, Malcolm R ^a   Carabateas, Philip M ^a   Josef, Kurt A ^a   Kumar, Virendra ^a   Weaver III, John D ^a   Arnold, Renee ^a   Casiano, Frances M ^a   Chippari, Susan M ^a   Haycock, Dean A ^a   Kuster, Joan E ^a   Luttinger, Daniel A ^a   Stevenson, Joan I ^a   Ward, Susan J ^a   Hill, W Adam ^b   Khanolkar, Atmaram ^b   Makriyannis, Alexandros ^b   more..

^a Sanofi Winthrop Inc   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID DERIVATIVE; CANNABINOID RECEPTOR; DRONABINOL; INDOLE DERIVATIVE; PRAVADOLINE;

ANIMAL TISSUE; ARTICLE; BRAIN; CEREBELLUM; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ELECTROSTIMULATION; MOUSE; NONHUMAN; RAT; SMOOTH MUSCLE CONTRACTION; STRUCTURE ACTIVITY RELATION; VAS DEFERENS;

ANIMALIA;

EID: 0030061811     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(95)00560-G     Document Type: Article

References (23)

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21. 2 or other receptors showed little or no binding.
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23. The enantioselectivity could be even greater, since contamination of the less active enantiomer by the more active has not been ruled out. Further studies on these enantiomers including determination of their absolute configuration are in progress.