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Volumn 38, Issue 15, 1997, Pages 2673-2676

A one-pot, efficient synthesis of the potent cytotoxic podophyllotoxin derivative NPF

Author keywords

[No Author keywords available]

Indexed keywords

4' BETA (4 FLUOROANILINO) 4' NOREPIPODOPHYLLOTOXIN; PODOPHYLLOTOXIN DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0030989428     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00450-4     Document Type: Article
Times cited : (32)

References (22)
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    • note
    • 3 (490 mg, 2.48 mmol) and 4-fluoroaniline (141 μL, 1.49 mmol) were added successively. The mixture was stirred overnight at room temperature, then filtered and concentrated under reduced pressure. Flash chromatography on silica gel with cyclohexane/ethyl acetate : 3/1 as eluent gave 322 mg of 2 (52%). Spectral data, specific rotation, and mp agree with those in the literature. 5


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