DNA methylation in mouse A-repeats in DNA methyltransferase-knockout ES cells and in normal cells determined by bisulfite genomic sequencing

Gene

Volumn 206, Issue 1, 1998, Pages 63-67

  Woodcock, David M ^a   Linsenmeyer, Martha E ^a   Warren, William D ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

CpG island; Embryonic development; Hypermethylation; L1; LINE1

Indexed keywords

BISULFITE; DNA; DNA METHYLTRANSFERASE; REPETITIVE DNA;

ANIMAL CELL; ARTICLE; CELL MUTANT; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA SEQUENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CELL LINE; CPG ISLANDS; DINUCLEOTIDE REPEATS; DNA; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA PRIMERS; GENE DELETION; HUMANS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; SEQUENCE ANALYSIS, DNA; SULFITES;

ANIMALIA; RODENTIA;

EID: 0032484604     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(97)00566-0     Document Type: Article

References (22)

1. Beard C., Li E., Jaenisch R. Loss of methylation activates Xist in somatic but not in embryonic cells. Genes Dev. 9:1995;2325-2334.
2. Bestor T.H. Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. EMBO J. 11:1992;2611-2617.
3. Bird A.P. Functions for DNA methylation in vertebrates. Cold Spring Harb. Symp. Quant. Biol. 58:1993;281-285.
4. Clark S.J., Harrison J., Frommer M. CpNpG methylation in mammalian cells. Nature Genet. 10:1995;20-27.
5. Doerfler W. Patterns of DNA methylation - evolutionary vestiges of foreign DNA inactivation as a host defense mechanism. Biol. Chem. Hoppe-Seyler. 372:1991;557-564.
6. Flynn J., Glickman J.F., Reich N.O. Murine DNA cytosine-C5 methyltransferase: pre-steady- and steady-state kinetic analysis with regulatory DNA sequences. Biochemistry. 35:1996;7308-7315.
7. Frommer M., McDonald L.E., Millar D.S., Collis C.M., Watt F., Grigg G.W., Molloy P.L., Paul C.L. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc. Natl. Acad. Sci. USA. 89:1992;1827-1831.
8. Hata K., Sakaki Y. Identification of critical CpG sites for repression of L1 transcription by DNA methylation. Gene. 189:1997;227-234.
9. Kafri T., Gao X., Razin A. Mechanistic aspects of genome-wide demethylation in the preimplantation mouse embryo. Proc. Natl. Acad. Sci. USA. 90:1993;10558-10562.
10. Lei H., Oh S.P., Okano M., Jutterman R., Goss K.A., Jaenisch R., Li E. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development. 122:1996;3195-3205.
11. Li E., Bestor T.H., Jaenisch R. Targeted mutation of the DNA methyltransferase results in embryonic lethality. Cell. 69:1992;915-926.
12. Li E., Beard C., Jaenisch R. Role for DNA methylation in genomic imprinting. Nature. 366:1993;362-365.
13. Monk M. Changes in DNA methylation during mouse embryonic development in relation to X-chromosome activity and imprinting. Phil. Trans. R. Soc. Lond. B. 326:1990;299-312.
14. Norris D.P., Patel D., Kay G.F., Penny G.D., Brockdorff N., Sheardown S.A., Rastan S. Evidence that random and imprinted Xist expression is controlled by preemptive methylation. Cell. 77:1994;41-51.
15. Pfeifer G.P., Steigerwald S.D., Hansen R.S., Gartler S.M., Riggs A.D. Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability. Proc. Natl. Acad. Sci. USA. 87:1990;8252-8256.
16. Schichman S.A., Adey N.B., Edgell M.H., Hutchison C. III L1 A-monomer tandem arrays have expanded during the course of mouse L1 evolution. Mol. Biol. Evol. 10:1993;552-570.
17. Snibson K.J., Woodcock D.M., Orian J.M., Brandon M.R., Adams T.E. Methylation and expression of a metallothionein promoter ovine growth hormone fusion gene (MT0GH1) in transgenic mice. Transgenic Res. 4:1995;114-122.
18. Tucker K.L., Beard C., Dausman J., Jackson-Grusby L., Laird P.W., Lei H., Li E., Jaenisch R. Germline passage is required for establishment of methylation and expression of imprinted but not of nonimprinted genes. Genes Dev. 10:1996;1008-1020.
19. Wang R.Y., Huang L.H., Ehrlich M. Human placental DNA methyltransferase: DNA substrate and DNA binding specificity. Nucleic Acids Res. 12:1984;3473-3490.
20. Wincker P., Jubier M.V., Roizes G. Unrelated sequences at the 5′ end of mouse LINE-1 repeated elements define two distinct subfamilies. Nucleic Acids Res. 15:1987;8593-8606.
21. Woodcock D.M., Lawler C.B., Linsenmeyer M.E., Warren W.D. Asymmetric methylation in the hyper-methylated CpG promoter region of the human L1 retrotransposon. J. Biol. Chem. 272:1997;7810-7816.
22. Zimmermann C., Guhl E., Graessmann A. Mouse DNA methyltransferase (MTase) deletion mutants that retain the catalytic domain display neither de novo nor maintenance methylation activity in vivo. Biol. Chem. 378:1997;393-405.