Murine cytomegalovirus infection-induced polyclonal B cell activation is independent of CD4+ T cells and CD40

Virology

Volumn 240, Issue 1, 1998, Pages 12-26

  Karupiah, Gunasegaran ^a,b   Sacks, Tamara E ^c   Klinman, Dennis M ^c   Fredrickson, Torgny N ^d   Hartley, Janet W ^a   Chen, Jian He ^b   Morse III, Herbert C ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^d AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD4 ANTIGEN; CD40 ANTIGEN; CD45 ANTIGEN; CONCANAVALIN A; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; MYOSIN; OVALBUMIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; FEMALE; FLOW CYTOMETRY; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION;

EID: 0032484474     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8900     Document Type: Article

References (45)

1. Banks T. A., Rouse B. T. Herpesviruses - Immune escape artists? Clin. Infect. Dis. 14:1992;933-941.
2. Bartholomaeus W. N., O'Donoghue H., Foti D., Lawson C. M., Shellam G. R., Reed W. D. Multiple autoantibodies following cytomegalovirus infection: Virus distribution and specificity of autoantibodies. Immunology. 64:1988;397-405.
3. Blackett S., Mims C. A. Studies of depressed interleukin-2 production by spleen cells from mice following infection with cytomegalovirus. Arch. Virol. 99:1988;1-8.
4. Bowen J. C., Daniel S., Rouse B. T. Virus infections and cytokines: Can we manage the interactions? Int. Rev. Immunol. 8:1992;33-41.
5. Breen E. C., Rezai A. R., Nakajima K., Beall G. N., Mitsuyasu R. T., Hirano T., Koshimoto T., Martinez-Maza O. Infection with HIV is associated with elevated IL-6 levels and production. J. Immunol. 144:1990;480-484.
6. Bruggeman C. A. Cytomegalovirus and latency: An overview. Virchows Arch. B Cell Pathol. 64:1993;325-333.
7. Campbell A. E., Slater J. S., Futch W. S. Murine cytomegalovirus-induced suppression of antigen-specific cytotoxic T lymphocyte maturation. Virology. 173:1989;268-275.
8. Cousens L. P., Orange J. S., Su H. C., Biron C. A. Interferon-α/β inhibition of interleukin 12 and interferon-γ productionin vitro. Proc. Natl. Acad. Sci. USA. 94:1997;634-639.
9. Dalton D. K., Pitts-Meek S., Keshav S., Figari I. S., Bradley A., Stewart T. A. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science. 259:1993;1739-1742.
10. Durie F. H., Foy T. M., Masters S. R., Laman J. D., Noelle R. J. The role of CD40 in the regulation of humoral and cell-mediated immunity. Immunol. Today. 15:1994;406-411.
11. Farrell H. E., Shellam G. R. Protection against murine cytomegalovirus infection by passive transfer of neutralizing and non-neutralizing monoclonal antibodies. J. Gen. Virol. 72:1991;149-156.
12. Fiala M., Mosca J. D., Barry P., Luciw P. A., Vinters H. V. Multi-step pathogenesis of AIDS - Role of cytomegalovirus. Res. Immunol. 142:1991;87-95.
13. +. Science. 253:1991;1417-1420.
14. Heise M. T., Virgin H. W. IV. The T cell-independent role of γ interferon and tumor necrosis factor α in macrophage activation during muring cytomegalovirus and herpes simplex virus infections. J. Virol. 69:1995;904-909.
15. Hirano T., Taga T., Yasukawa K., Nakajima K., Nakano N., Takutsuki F., Shimizu M., Murashima A., Tsunasawa S., Sakiyama F., Kishimoto T. Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production. Proc. Natl. Acad. Sci. USA. 84:1987;228-231.
16. Ho M. Role of specific cytotoxic lymphocytes in cellular immunity against murine cytomegalovirus. Infect. Immun. 27:1980;767-776.
17. Ho M. Cytomegalovirus Biology and Infection. 1991a;Plenum, New York. p. 249.
18. Ho M. Cytomegalovirus Biology and Infection. 1991b;Plenum, New York. p. 327.
19. Hudson J. B. The murine cytomegalovirus as a model for the study of viral pathogenesis and persistent infections. Arch. Virol. 62:1979;1-29.
20. Hutt-Fletcher L. M., Balachandran N., Elkins M. H. B cell activation by cytomegalovirus. J. Exp. Med. 158:1983;2171-2176.
21. +. J. Exp. Med. 169:1989;1199-1212.
22. Jonjic S., Pavic I., Polic B., Crnkovic I., Lucin P., Koszinowski U. H. Antibodies are not essential for the resolution of primary cytomegalovirus infection but limit dissemination of recurrent virus. J. Exp. Med. 179:1994;1713-1717.
23. Karupiah G., Fredrickson T. N., Holmes K. L., Khairallah L. H., Buller R. M. L. Importance of interferons in recovery from mousepox. J. Virol. 67:1993;4214-4226.
24. Kawabe T., Naka T., Yoshida K., Tanaka T., Fujiwara H., Suematsu S., Yoshida N., Kishimoto T., Kikutani H. The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation. Immunity. 1:1994;167-178.
25. Kelsey D. K., Overall J. C. Jr., Glasgow L. A. Correlation of the suppression of mitogen responsiveness and the mixed lymphocyte reaction with the proliferative response to viral antigen of splenic lymphocytes from cytomegalovirus-infected mice. J. Immunol. 121:1978;464-470.
26. Klemola E., von Essen R., Henle G., Henle W. Infectious-mononucleosis-like disease with negative heterophil agglutination test: Clinical features in relation to Epstein-Barr virus and cytomegalovirus antibodies. J. Infect. Dis. 121:1970;608-614.
27. Klinman D. M., Steinberg A. D. Proliferation of anti-DNA-producing NZB B cells in a non-autoimmune environment. J. Immunol. 137:1986;69-75.
28. Klinman D. M., Steinberg A. D. Systemic autoimmune disease arises from polyclonal B cell activation. J. Exp. Med. 165:1987;1755-1760.
29. Kopf M., Baumann H., Freer G., Freudenberg M., Lamers M., Kishimoto T., Zinkernagel R., Bluethmann H., Kohler G. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature. 368:1994;339-342.
30. Koszinowski U. H., Del Val M., Reddehase M. J. Cellular and molecular basis of the protective immune response to cytomegalovirus infection. Curr. Top. Microbiol. Immunol. 154:1990;189-220.
31. Loh L., Hudson J. B. Murine cytomegalovirus infection in the spleen and its relationship to immunosuppression. Infect. Immun. 32:1981;1067-1072.
32. Monestier M., Manheimer-Lory A., Bellon B., Painter C., Dang H., Talal N., Zanetti M., Schwartz R., Pisetsky D., Kuppers R., Rose N., Brochier J., Klareskog L., Holmdahl R., Erlanger B., Alt F., Bona C. Shared idiotypes and restricted immunoglobulin variable region heavy chain genes characterize murine autoantibodies of various specificities. J. Clin. Invest. 78:1986;753-759.
33. Moskowitz L., Hensley G. T., Chan J. C., Adams K. Immediate causes of death in acquired immunodeficiency syndrome. Arch. Pathol. Lab. Med. 109:1985;735-738.
34. Neiman P., Wasserman P. B., Wentworth B. B., Kao G. F., Lerner K. G., Storb R., Buckner C. D., Clift R. A., Fefer A., Fass L., Glucksberg H., Thomas E. D. Interstitial pneumonia and cytomegalovirus infection as complications of human marrow transplantation. Transplantation. 15:1973;478-485.
35. Nicholas J. A., Levely M. E., Brideau R. J., Berger A. E. During recovery from cytomegalovirus infection T-lymphocyte subsets become selectively responsive to activation and have depressed interleukin 2 (IL2) secretion and IL2 receptor expression. Microbial Pathogen. 2:1987;37-47.
36. Oka Y., Rolink A. G., Suematsu S., Kishimoto T., Melchers F. An interleukin-6 transgene expressed in B lymphocyte lineage cells overcomes the T cell-dependent establishment of normal levels of switched immunoglobulin isotypes. Eur. J. Immunol. 25:1995;1332-1337.
37. Orange J. S., Biron C. A. Characterization of early IL-12, IFN-αβ, and TNF effects of antiviral state and NK cell responses during murine cytomegalovirus infection. J. Immunol. 156:1996;4746-4756.
38. +. Proc. Natl. Acad. Sci. USA. 87:1990;2379-2383.
39. Price P., Oliver S. D., Gibbons A. E., Shellam G. R. B-cell activation following murine cytomegalovirus infection: Implications for autoimmunity. Immunology. 78:1993;14-21.
40. Ruzek M. C., Miller A. H., Opal S. M., Pearce B. D., Biron C. A. Characterization of early cytokine responses and an interleukin (IL)-6-dependent pathway of endogenous glucocorticoid induction during murine cytomegalovirus infection. J. Exp. Med. 185:1997;1185-1192.
41. Selgrade M. K., Ahmed A., Sell K. W., Gershwin M. E., Steinberg A. D. Effect of murine cytomegalovirus on the in vitro responses of T and B cells to mitogens. J. Immunol. 116:1976;1459-1465.
42. Shanley J. D., Jordan M. C., Stevens J. G. Modification by adoptive humoral immunity of murine cytomegalovirus infection. J. Infect. Dis. 143:1981;231-237.
43. Snapper C. M., Yamaguchi H., Moorman M. A., Sneed R., Smoot D., Mond J. J. Natural killer cells induce activated murine B cells to secrete Ig. J. Immunol. 151:1993;5251-5260.
44. Svetic A., Finkelman F. D., Jian Y. C., Dieffenbach C. W., Scott D. E., McCarthy K. F., Steinberg A. D., Gause W. C. Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J. Immunol. 147:1991;2391-2397.
45. Wynn T. A., Eltoum I., Cheever A. W., Lewis F. A., Gause W. C., Sher A. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs ofSchistosoma mansoni. J. Immunol. 151:1993;1430-1440.