The single helix in protein L is largely disrupted at the rate-limiting step in folding

Journal of Molecular Biology

Volumn 284, Issue 3, 1998, Pages 807-815

  Kim, David E ^a   Yi, Qian ^a   Gladwin, Sharon T ^a   Goldberg, Jonathan M ^b   Baker, David ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Hydrophobic association; Protein folding kinetics; Protein L; Transition state; helix formation

Indexed keywords

GLYCINE; GLYCINE CLEAVAGE SYSTEM;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE;

TRIXIS;

EID: 0032484161     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2200     Document Type: Article

References (6)

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2. Fersht, A. R., Itzhaki, L. S., El Masry, N. F., Matthews, J. M. & Otzen, D. E. 1994 Single versus parallel pathways of protein folding and fractional formation of structure in the transition state Proc. Natl Acad. Sci. USA 91 10426-10429
3. Gilmanshin, R., Williams, S., Callender, R. H., Woodruff, W. H. & Dyer, R. B. 1997 Fast events in protein folding: relaxation dynamics of secondary and tertiary structure in native apomyoglobin Proc. Natl Acad. Sci. USA 94 3709-3713
4. Itzhaki, L. S., Neira, J. L., Ruiz-Sanz, J., de Prat Gay, G. & Fersht, A. R. 1995b Search for nucleation sites in smaller fragments of chymotrypsin inhibitor 2 J. Mol. Biol. 254 289-304
5. Thompson, P. A., Eaton, W. A. & Hofrichter, J. 1997 Laser temperature jump study of the helix ⇔ coil kinetics of an alanine peptide interpreted with a 'kinetic zipper' model Biochemistry 36 9200-9210
6. Williams, S, Causgrove, T. P., Gilmanshin, R., Fang, K. S., Callender, R. H., Woodruff, W. H. & Dyer, R. B. 1996 Fast events in protein folding: helix melting and formation in a small peptide Biochemistry 35 691-697