Regulation of Drosophila Adh promoter switching by an initiator-targeted repression mechanism

EMBO Journal

Volumn 17, Issue 4, 1998, Pages 1076-1086

  Ren, Bing ^a   Maniatis, Tom ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

Adh; AEF 1; Core promoter; Initiator; Repression

Indexed keywords

ALCOHOL DEHYDROGENASE; ZINC FINGER PROTEIN;

ARTICLE; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; GENE ACTIVATION; GENE REPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION;

ALCOHOL DEHYDROGENASE; ANIMALS; BINDING SITES; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; ENZYME REPRESSION; GENES, INSECT; NUCLEAR PROTEINS; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

ARACHNIDA; HEXAPODA;

EID: 0032481378     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.4.1076     Document Type: Article

References (35)

1. Abel, T. (1993) Transcription factors that bind to Drosophila Adh regulatory elements. Ph.D. thesis. Harvard University, Cambridge, MA, USA.
2. An, W. and Wensink, P.C. (1995) Integrating sex- and tissue-specific regulation within a single Drosophila enhancer. Genes Dev., 9, 256-266.
3. Bateman, E. and Paule, M.R. (1988) Promoter occlusion during ribosomal RNA transcription. Cell, 54, 985-992.
4. Benyajati, C., Spoerel, N., Haymerle, H. and Ashburner, M. (1983) The messenger RNA for alcohol dehydrogenase in Drosophila melanogaster differs in its 5′ end in different developmental stages. Cell, 33, 125-133.
5. Chen, C.A. and Okayama, H. (1988) Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA. Biotechniques, 6, 632-638.
6. Corbin, V. and Maniatis, T. (1989a) The role of specific enhancer-promoter interactions in the Drosophila Adh promoter switch. Genes Dev., 3, 2191-2120.
7. Corbin, V. and Maniatis, T. (1989b) Role of transcriptional interference in the Drosophila melanogaster Adh promoter switch. Nature, 337, 279-282.
8. Corbin, V. and Maniatis, T. (1990) Identification of cis-regulatory elements required for larval expression of the Drosophila melanogaster alcohol dehydrogenase gene. Genetics, 124, 637-646.
9. Das, G., Hinkley, C.S. and Herr, W. (1995) Basal promoter elements as a selective determinant of transcriptional activator function. Nature, 374, 657-660.
10. Dostatni, N., Lambert, P.F., Sousa, R. Ham, J. Howley, P.M. and Yaniv, M. (1991) The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex. Genes Dev., 5, 1657-1671.
11. Falb, D. and Maniatis, T. (1992a) A conserved regulatory unit implicated in tissue-specific gene expression in Drosophila and man. Genes Dev., 6, 454-465.
12. Falb, D. and Maniatis, T. (1992b) Drosophila transcriptional repressor protein that binds specifically to negative control elements in fat body enhancers. Mol. Cell Biol., 12, 4093-4103.
13. Goldberg, D.A., Posakony, J.W. and Maniatis, T. (1983) Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the Drosophila germ line. Cell, 34, 59-73.
14. Gorman, C.M., Moffat, L.F. and Howard, B.H. (1982) Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol., 2, 1044-1051.
15. Hansen, S.K. and Tjian, R. (1995) TAFs and TFIIA mediate differential utilization of the tandem Adh promoters. Cell, 82, 565-575.
16. Hansen, U., Tenen, D.G., Livingston, D.M. and Sharp, P.A. (1981) T antigen repression of SV40 early transcription from two promoters. Cell, 27, 603-613.
17. Karess, R.E. and Rubin, G.M. (1984) Analysis of P transposable element functions in Drosophila. Cell, 38, 135-146.
18. Kato, H., Horikoshi, M. and Roeder, R.G. (1991) Repression of HIV-1 transcription by a cellular protein. Science, 251, 1476-1480.
19. Kaufman, P.D. and Rio, D.C. (1991) Drosophila P-element transposase is a transcriptional repressor in vitro. Proc. Natl Acad. Sci. USA, 88, 2613-2617.
20. Lee, G., Wu, J., Luu, P., Ghazal, P. and Flores, O. (1996) Inhibition of the association of RNA polymerase II with the preinitiation complex by a viral transcriptional repressor. Proc. Natl Acad. Sci. USA, 93, 2570-2575.
21. Li, L.H., Nerlov, C., Prendergast, G., MacGregor, D. and Ziff, E.B. (1994) c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II. EMBO J., 13, 4070-4079.
22. Macias, M.P. and Stinski, M.F. (1993) An in vitro system for human cytomegalovirus immediate early 2 protein (IE2)-mediated site- dependent repression of transcription and direct binding of IE2 to the major immediate early promoter. Proc. Natl Acad. Sci. USA, 90, 707-711.
23. Melton, D.A., Krieg, P.A., Rebagliati, M.R., Maniatis, T., Zinn, K. and Green, M.R. (1984) Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res., 12, 7035-7056.
24. Nikolov, D.B. and Burley, S.K. (1997) RNA polymerase II transcription initiation: a structural view. Proc. Natl Acad. Sci. USA, 94, 15-22.
25. Novina, C.D. and Roy, A.L. (1996) Core promoters and transcriptional control. Trends Genet., 12, 351-354.
26. Parker, C.S. and Topol, J. (1984) A Drosophila RNA polymerase II transcription factor contains a promoter-region-specific DNA-binding activity. Cell, 36, 357-369.
27. Reed, R. (1996) Initial splice-site recognition and pairing during pre- mRNA splicing. Curr. Opin. Genet. Dev., 6, 215-220.
28. Roeder, R.G. (1996) The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem. Sci., 21, 327-335.
29. Rubin, G.M. and Spradling, A.C. (1982) Genetic transformation of Drosophila with transposable element vectors. Science, 218, 348-353.
30. Schwyter, D.H., Huang, J., Dubnicoff, T. and Courey, A.J. (1995) The decapentaplegic core promoter region plays an integral role in the spatial control of transcription. Mol. Cell. Biol., 15, 3960-3968.
31. II145 function as a core promoter selectivity factor, not a general coactivator. Cell, 90, 615-624.
32. Spradling, A.C. and Rubin, G.M. (1982) Transposition of cloned P elements into Drosophila germ line chromosomes. Science, 218, 341-347.
33. Thanos, D. and Maniatis, T. (1995) Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell, 83, 1091-1100.
34. Tjian, R. (1981) T antigen binding and the control of SV40 gene expression. Cell, 26, 1-2.
35. Wu, J., Jupp, R., Stenberg, R.M., Nelson, J.A. and Ghazal, P. (1993) Site- specific inhibition of RNA polymerase II preinitiation complex assembly by human cytomegalovirus IE86 protein. J. Virol., 67, 7547-7555.