Novel quinolone derivatives as potent antibacterials

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 5, 1998, Pages 525-528

  Lohray, Braj B ^a   Baskaran, S ^a   Srinivasa Rao, Bonthu ^a   Mallesham, B ^a   Bharath, K S N ^a   Yadi Reddy, B ^a   Venkateswarlu, S ^a   Sadhukhan, Ashok K ^b   Kumar, M Sitaram ^b   Sarnaik, Hemant M ^b  

^a Dept of Med Chem and Drug Discov ^*  (India)

^b DR REDDY S RESEARCH FOUNDATION   (India)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 7 (3,4 N,N' DIMETHYLDIAMINO 6,8 DIFLUORO 1,4 DIHYDRO 1 CYCLOPROPYL 4 OXOQUINOLINE 3 CARBOXYLIC ACID; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN;

ANTI-BACTERIAL AGENTS; BACTERIA; MICROBIAL SENSITIVITY TESTS; QUINOLONES; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032478248     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00063-8     Document Type: Article

References (11)

1. 1. Koga, H.; Itoh, A.; Murayama, S.; Suzue, S.; Irikura, T. J. Med. Chem. 1980, 23, 1358.
2. 2. Gootz, T. D.; Brighty, K. E. Med. Res. Rev. 1996, 16, 433.
3. 3. Goneffon, Y.; Montay, G.; Roquet, F.; Besson, M. C. R. Hebd. Seance Acad. Sci. 1981, 292, 37.
4. 4. Wise, R. Anews, J. M.; Edwards, L. J. Antimicrob. Agents. Chemother. 1983, 23, 559.
5. 5. Matsumoto, T.; Miyamoto, T.; Minamida, A. Nishimura, Y.; Egawa, H. J. Med. Chem. 1984, 27, 292.
6. 6. Sato, K.; Matsuura, Y. Inone, M.; Une, T.; Osada, Y.; Ogawa, H.; Mitsuhashi, S. Antimicrob. Agents. Chemother. 1982, 22, 548.
7. 7. Llorente, B.; Leclerc, F.; Cedergren, R. Bioorg. Med. Chem. 1996, 4, 61.
8. 8. Sanchez, J. P.; Domagala, J. M.; Hagen, S. E.; Heifetz, C. L.; Hutt, M. P.; Nichols, J. B.; Trehan, A. K. J. Med. Chem. 1988, 31, 983.
9. 9. Skarzewski, J.; Gupta, A. Tetrahedron : Asymmetry, 1997, 8, 1861.
10. 10. Kimura, Y.; Atarashi, S.; Takahashi, M.; Hayakawa, I. Chem. Pharm. Bull. 1994, 42, 1442.
11. 11. Miyamoto, T.; Matsumoto, J.; Chiba, K.; Egawa, H.; Shibamori, K.; Minamide, A.; Nishimura, Y.; Okada, H.; Kataoka, M.; Fujita, M.; Hirose, T.; Nakano, J. J. Med. Chem. 1990, 33, 1645.