Recognition of 2'-deoxyisoguanosine triphosphate by HIV-1 reverse transcriptase and mammalian cellular DNA polymerases

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 5, 1998, Pages 499-504

  Lutz, Michael J ^a,c   Horlacher, Jennifer ^a   Benner, Steven A ^b  

^a ETH ZURICH   (Switzerland)

^b University of Florida ^*  (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2' DEOXYISOGUANOSINE TRIPHOSPHATE; CELL DNA; DEOXYADENOSINE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE ALPHA; RNA DIRECTED DNA POLYMERASE; THYMIDINE; UNCLASSIFIED DRUG; URACIL;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN;

NON-PROGRAMMATIC;

BASE SEQUENCE; DNA; DNA-DIRECTED DNA POLYMERASE; GUANOSINE; HIV-1 REVERSE TRANSCRIPTASE; SUBSTRATE SPECIFICITY; TEMPLATES, GENETIC;

EID: 0032478060     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00057-2     Document Type: Article

References (18)

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10. 35S] dATP (400 Ci/mmol) was from Amersham. Purification of HIV-1 RT, annealing of the DNA primer with either the DNA or RNA template, and enzymatic assays were performed as recently described (in ref 5).
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